“Turn-on” fluorescence sensing of cytosine: development of a chemosensor for quantification of cytosine in human cancer cells

Abstract

Pyrene appended 5-hydroxyisophthalic acid derivative (PIA) has been developed and characterized for selective detection and quantification of cytosine in different human cancer cells.

Visualisation of DCP, a nerve agent mimic, in Catfish brain by a simple chemosensor

“…But the problem arises when these existing methods show one or more drawbacks such as low response and sensitivity, limited selectivity, non-specificity and non-portability, difficulties in real time detection, false positive readings and operational complexity. The chemosensors mediated detection is an extremely convenient and simple method based on optical outputs such as color change or change in fluorescence intensity after the exposure to the target analytes 32 – 35 . Chemosensors make such detection method attractive and widely acceptable by fulfilling the key features of a practical sensing system i.e.…”

Structure‐Property Correlation of C10‐(H)‐Arylated‐N‐(pyren‐1‐yl)‐picolinamide Regioisomers towards Cu2+ and Fe3+ Sensing

“…[28] Another pyrene-appended 5-hydroxyisophthalic acid derivative constitute a fluorescence turn-on sensor which executed selective recognition of cytosine in cancer cells through PET mechanism. [29] Pyrene sensors have been efficiently utilized to sense metal ions such as Cu 2 + and Fe 3 + that are ubiquitious in biological systems and play pivotal roles in metabolic processes. [12,[31][32][33][34][35][36][37][38][39][40][41][42] Cu 2 + is an integral part of several metalloenzymes and proteins while Fe 3 + plays paramount roles in several enzymatic reactions, oxygen transport and cellular metabolism.…”

“…Apart from metal ion sensing, pyrene-based chemosensors are also targeted towards detecting neutral and macromolecules. [27][28][29][30] Schmuck and co-workers developed a pyrene-based cationic oligopeptide that efficiently binded with double stranded (ds-) DNA. [28] The probe exhibited strong excimer emission in free solution as it existed in a folded state.…”

Highly Selective Optical and Fluorescence “Turn On” Signaling of Al3+: Cell Imaging and Estimation in Rice Plant

“…In recent years certain analytical approaches have been reported for the detection and quantification of bio‐relevant metal ions, but many of them are associated with various crucial drawbacks . But chemosensors based on fluorescent and optical signaling method turn out to be a promising device owing to its remarkable selectivity and sensitivity, portability, low cost, instant responds, naked eye detection facilities to estimate metal ions in analytical, medical, environmental and biological fields . However the detection of Al is always challenging than the other metal ions due to its high hydration ability in water, poor coordination ability and lack of spectroscopic characterization, thus development of a simple but very precise chemosensor for Al detection is a significant domain of research.…”