Turbulent flow and Particle Deposition in the Trachea

Owen, P. R.

doi:10.1002/9780470719671.ch14

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Turbulent Deposition1

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2011

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Cited by 11 publications

(1 citation statement)

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“…Particle deposition within the trachea tends to increase in turbulence. Submicron particles are injected into the laminar boundary layer by turbulent eddies, where they may deposit by Brownian diffusion (Owen, 1969). Eddies may cause larger particles to be projected towards the tracheal wall at a local rate higher than would occur in the absence of any secondary flow thus enhancing their inertial deposition (Davies, 1966).…”

Section: Turbulent Depositionmentioning

confidence: 99%

Pressurized metered-dose inhaler (pMDI) aerosol deposition : measurements in add-on spacers

Alhegagi¹

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Section: Turbulent Depositionmentioning

confidence: 99%

Pressurized metered-dose inhaler (pMDI) aerosol deposition : measurements in add-on spacers

Alhegagi¹

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Particle Deposition Within Bronchial Airways: Comparisons Using Constant and Cyclic Inspiratory Flows

Schlesinger¹,

GURMAN²,

LIPPMANN³

1982

Inhaled Particles V

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Growth Rate Measurements and Deposition Modelling of Hygroscopic Aerosols in Human Tracheobronchial Models

Martonen

Bell

Phalen

et al. 1982

Inhaled Particles V

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Abstract-A laboratory system has been developed in which the atmosphere and fluid dynamics of the upper tracheobronchial (TB) tree of the human are simulated. It is used to measure the hygroscopic growth rates of monodisperse NaCl and bronchodilator (Isuprel® hydrochloride with and without glycerine) aerosols. Dry particles are mixed with water vapour-laden air at the entrance to a growth chamber temperature controlled at 37°C with a relative humidity (RH) between 88 and 95%. Hygroscopic growth rates increased with degree of RH and magnitude of Reynolds number in the chamber. The growth data are incorporated into an aerosol deposition model to calculate the effect of hygroscopic growth upon the dose distribution of medicinal aerosols in the human TB network. The model uses some original deposition formulae to compute particle deposition efficiencies. Calculations show that the rate of water vapour absorption within TB airways is an important factor affecting the fate of particles used in aerosol therapy. NOMENCLATUREThe nomenclature used in the development of theoretical formulae is as follows:

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Turbulent flow and Particle Deposition in the Trachea

Cited by 11 publications

References 12 publications

Pressurized metered-dose inhaler (pMDI) aerosol deposition : measurements in add-on spacers

Pressurized metered-dose inhaler (pMDI) aerosol deposition : measurements in add-on spacers

Particle Deposition Within Bronchial Airways: Comparisons Using Constant and Cyclic Inspiratory Flows

Growth Rate Measurements and Deposition Modelling of Hygroscopic Aerosols in Human Tracheobronchial Models

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