Growth Rate Measurements and Deposition Modelling of Hygroscopic Aerosols in Human Tracheobronchial Models

Martonen, T. B.; Bell, Karl A.; Phalen, Robert F.; Wilson, Archie F.; Ho, Abraham T.

doi:10.1016/b978-0-08-026838-5.50011-8

Cited by 23 publications

(25 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In three of these, there was a direct relationship between the differences in % fall in FEV 1 and PI on the two study days (subjects Nos. [12][13][14]. Only in 3 of the 6 subjects with d values for PI >0 (subjects Nos.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Regional deposition of saline aerosols of different tonicities in normal and asthmatic subjects

Phipps

Gonda²,

Anderson³

et al. 1994

Eur Respir J

View full text Add to dashboard Cite

R Re eg gi io on na al l d de ep po os si it ti io on n o of f s sa al li in ne e a ae er ro os so ol ls s o of f d di if ff fe er re en nt t t to on ni ic ci it ti ie es s i inABSTRACT: Nonisotonic aerosols are frequently used in the diagnosis and therapy of lung disease. The purpose of this work was to study the difference in the pattern of deposition of aerosols containing aqueous solutions of different tonicities. 99m Technetium-diethyltriaminepentaacetic acid ( 99m Tc-DTPA)-labelled saline aerosols, with mass median aerodynamic diameter 3.7-3.8 µm and geometric standard deviation 1.4, were inhaled under reproducible breathing conditions on two occasions. Hypotonic and hypertonic solutions were used in 11 normals subjects, isotonic and hypertonic solutions in 9 asthmatics. The regional deposition was quantified by a penetration index measured with the help of a tomographic technique.There was a small but significant increase (6.7%) in the penetration index of the hypotonic as compared to the hypertonic aerosols in the normal subjects. The region that was markedly affected was the trachea. The differences in the penetration of the isotonic and hypertonic aerosols in the asthmatics appeared to be strongly dependent on the state of the airways at the time of the study.These findings can be interpreted in terms of effects of growth or shrinkage of nonisotonic aerosols, as well as of airway narrowing, on regional deposition of aerosols. Tonicity of aerosols appears to affect their deposition both through physical and physiological mechanisms. This should be taken into account when interpreting the effects of inhaled aqueous solutions of various tonicities in patients in vivo.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The effects of hygroscopic growth on deposition have been studied theoretically and experimentally in vitro [11][12][13][14][15][16], and in vivo [17][18][19][20]. However, until recently [9,10,18], there have been no in vivo experimental data on the effect of growth or shrinkage on regional deposition of aerosols in humans.…”

mentioning

confidence: 99%

Regional deposition of saline aerosols of different tonicities in normal and asthmatic subjects

Phipps

Gonda²,

Anderson³

et al. 1994

Eur Respir J

View full text Add to dashboard Cite

show abstract

“…The deposition profile along the respiratory tract is altered and individuals exposed to such airborne matter may be subjected to enhanced or reduced deposition rates compared to those of insoluble particles (Martonen et al, 1982). The effect of water uptake on deposition efficiency of soluble aerosols in the human respiratory system has been investigated experimentally and theoretically (Blanchard and Willeke, 1984;Broday and Georgopolous, 2001).…”

Section: Introductionmentioning

confidence: 99%

Particle Deposition in Human Respiratory Tract: Effect of Water-Soluble Fraction

Varghese

Gangamma

2006

Aerosol Air Qual. Res.

View full text Add to dashboard Cite

In the nearly saturated human respiratory tract, the presence of water-soluble substances in inhaled aerosols can cause change in the size distribution of particles. This consequently alters the lung deposition profiles of the inhaled airborne particles. The magnitude of particle deposition in the lung is affected by the soluble component present in the particle. This is estimated by a numerical model. The model solves the condensation growth equation to determine the size evolution of respirable particles within the human respiratory tract. The water uptake by the particles in the respiratory tract results in change of size and density of the particles, and these changes are incorporated for estimating the particle deposition efficiency. The model results are compared with experimental results of sodium chloride particles. The model reproduces the major features of the experimental data. The simulations indicate that the particle can grow up to two times or more of its original size due to water uptake, depending on the quantity of the soluble matter it carries and thus can have significant effect on particle deposition efficiency. The study investigated the effect of soluble compounds in estimating total and regional lung dose of ambient particulate matter measured in Mumbai, India. The particle mass size distribution and composition considered for the ambient particulate matter, the variation in the total mass dose due to the growth was modest. But, the regional lung dose was significantly affected by the hygroscopic growth.

show abstract

“…One of the major problems that exist in estimating the deposition pattern is the limited information that is available on the hygroscopicity of common indoor aerosol particles. Several models have been developed to account for the hygroscopic growth of particles (Ferron, 1977;Martonen, 1982;Martonen et al, 1982; Egan and Nixon, *To whom correspondence should be addressed.…”

Section: Introductionmentioning

confidence: 99%

Initial Size Distributions and Hygroscopicity of Indoor Combustion Aerosol Particles

Hopke

1993

Aerosol Science and Technology

119

View full text Add to dashboard Cite

Growth Rate Measurements and Deposition Modelling of Hygroscopic Aerosols in Human Tracheobronchial Models

Cited by 23 publications

References 14 publications

Regional deposition of saline aerosols of different tonicities in normal and asthmatic subjects

Regional deposition of saline aerosols of different tonicities in normal and asthmatic subjects

Particle Deposition in Human Respiratory Tract: Effect of Water-Soluble Fraction

Initial Size Distributions and Hygroscopicity of Indoor Combustion Aerosol Particles

Contact Info

Product

Resources

About