Tunneling nanotubes: A new route for the exchange of components between animal cells

Gerdes, Hans‐Hermann; Bukoreshtliev, Nickolay V.; Barroso, João Filipe

doi:10.1016/j.febslet.2007.03.071

Cited by 271 publications

(285 citation statements)

References 60 publications

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“…Viruses move along the outer surfaces of conduits toward the target cell, appearing as a stretched virological synapse (24,34). Conduits are thin-membrane extensions, longer than 5 μm, that are believed to be formed by directed outgrowth of a filopodium-like protrusion toward a neighboring cell or by dislodgment after direct cell contact interaction (35)(36)(37). In our studies, we did not document "surfing" of HTLV-1 virions on the outside of cellular conduits.…”

Section: Discussionmentioning

confidence: 65%

Human T-cell leukemia virus type 1 p8 protein increases cellular conduits and virus transmission

Prooyen

Gold

Andresen

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

139

212

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The human T-cell leukemia virus type 1 (HTLV-1) is the cause of adult T-cell leukemia/lymphoma as well as tropical spastic paraparesis/ HTLV-1-associated myelopathy. HTLV-1 is transmitted to T cells through the virological synapse and by extracellular viral assemblies. Here, we uncovered an additional mechanism of virus transmission that is regulated by the HTLV-1-encoded p8 protein. We found that the p8 protein, known to anergize T cells, is also able to increase T-cell contact through lymphocyte function-associated antigen-1 clustering. In addition, p8 augments the number and length of cellular conduits among T cells and is transferred to neighboring T cells through these conduits. p8, by establishing a T-cell network, enhances the envelope-dependent transmission of HTLV-1. Thus, the ability of p8 to simultaneously anergize and cluster T cells, together with its induction of cellular conduits, secures virus propagation while avoiding the host's immune surveillance. This work identifies p8 as a viral target for the development of therapeutic strategies that may limit the expansion of infected cells in HTLV-1 carriers and decrease HTLV-1-associated morbidity.human leukemia retrovirus | orf-I

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Section: Discussionmentioning

confidence: 65%

Human T-cell leukemia virus type 1 p8 protein increases cellular conduits and virus transmission

Prooyen

Gold

Andresen

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

139

212

View full text Add to dashboard Cite

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“…Taken together, TNT development in cells appears to take place particularly under stress and may be one way to transfer cellular substances from stressed cells to healthy cells which may increase their stress resistance. However, TNT existence is not always dependent on stress and is also linked to cell type [33,34].…”

Section: (B) Astrocytesmentioning

confidence: 99%

“…In WT, the focus is on the potential role of the tunnellingnanotube type of WT in the brain (table 2) [3,13] based on the original work of Gerdes and co-workers [32][33][34]. Table 1.…”

Section: Introductionmentioning

confidence: 99%

Extracellular-vesicle type of volume transmission and tunnelling-nanotube type of wiring transmission add a new dimension to brain neuro-glial networks

Agnati

Fuxé

2014

Phil. Trans. R. Soc. B

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Two major types of intercellular communication are found in the central nervous system (CNS), namely wiring transmission (WT; point-to-point communication via private channels, e.g. synaptic transmission) and volume transmission (VT; communication in the extracellular fluid and in the cerebrospinal fluid). Volume and synaptic transmission become integrated because their chemical signals activate different types of interacting receptors in heteroreceptor complexes located synaptically and extrasynaptically in the plasma membrane. In VT, we focus on the role of the extracellular-vesicle type of VT, and in WT, on the potential role of the tunnelling-nanotube (TNT) type of WT. The so-called exosomes appear to be the major vesicular carrier for intercellular communication but the larger microvesicles also participate. Extracellular vesicles are released from cultured cortical neurons and different types of glial cells and modulate the signalling of the neuronal -glial networks of the CNS. This type of VT has pathological relevance, and epigenetic mechanisms may participate in the modulation of extracellular-vesicle-mediated VT. Gerdes and co-workers proposed the existence of a novel type of WT based on TNTs, which are straight transcellular channels leading to the formation in vitro of syncytial cellular networks found also in neuronal and glial cultures.

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“…11 TNTs are suggested to transfer endosome-related organelles, surface receptors, mitochondria, lysosomes, GPI-anchored GFP and calcium fluxes. 12 Some particles like human immunodeficiency virus (HIV) and PrP Sc use TNTs as infection highways to transfer from one cell to another. [13][14][15][16] However, the development mechanisms of TNTs are still unknown.…”

mentioning

confidence: 99%

Tunneling-nanotube development in astrocytes depends on p53 activation

et al. 2010

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Tunneling nanotubes (TNTs) can be induced in rat hippocampal astrocytes and neurons with H 2 O 2 or serum depletion. Major cytoskeletal component of TNTs is F-actin. TNTs transfer endoplasmic reticulum, mitochondria, Golgi, endosome and intracellular as well as extracellular amyloid b. TNT development is a property of cells under stress. When two populations of cells are co-cultured, it is the stressed cells that always develop TNTs toward the unstressed cells. p53 is crucial for TNT development. When p53 function is deleted by either dominant negative construct or siRNAs, TNT development is inhibited. In addition, we find that among the genes activated by p53, epidermal growth factor receptor is also important to TNT development. Akt, phosphoinositide 3-kinase and mTOR are involved in TNT induction. Our data suggest that TNTs might be a mechanism for cells to respond to harmful signals and transfer cellular substances or energy to another cell under stress.

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Tunneling nanotubes: A new route for the exchange of components between animal cells

Cited by 271 publications

References 60 publications

Human T-cell leukemia virus type 1 p8 protein increases cellular conduits and virus transmission

Human T-cell leukemia virus type 1 p8 protein increases cellular conduits and virus transmission

Extracellular-vesicle type of volume transmission and tunnelling-nanotube type of wiring transmission add a new dimension to brain neuro-glial networks

Tunneling-nanotube development in astrocytes depends on p53 activation

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