Tunneling-nanotube development in astrocytes depends on p53 activation

Wang, Y; Cui, Jia; Sun, Xiao; Zhang, Y

doi:10.1038/cdd.2010.147

Cited by 316 publications

(432 citation statements)

References 37 publications

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“…The M-Sec-Ral-exocyst pathway seems activated by both p53 and the p53-induced Akt-PI3K-mTOR cascade. Furthermore, hydrogen peroxide changed membrane and cytoskeleton properties and increased TNT connections in astrocytes [110] and induced TNT in hippocampal astrocytes and neurons [74]. Taken together, TNT development in cells appears to take place particularly under stress and may be one way to transfer cellular substances from stressed cells to healthy cells which may increase their stress resistance.…”

Section: (B) Astrocytesmentioning

confidence: 97%

“…However, in astrocytes, it was found that the TNT formation is dependent on p53 activation, a tumour suppressor protein giving cellular and genomic stability [74]. When p53 function is deleted by either dominant negative constructs or siRNAs, TNT development is inhibited.…”

Section: (B) Astrocytesmentioning

confidence: 99%

“…The astrocytic EMVs move into the extracellular space and carry a large number of transfer compounds such as mitochondria, mitochondrial DNA (mtDNA), ATP, Hsp70, functional glutamate transporters, FGF-2, miRNA, etc. (table 3) [68,[73][74][75][76][77][78]. The acceptor cells are both astrocytes and neurons and dependent on the cargo in the EMVs they may produce, for example, neuroprotection or degeneration [68,79,80].…”

Section: (C) Central Nervous Systemmentioning

confidence: 99%

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Extracellular-vesicle type of volume transmission and tunnelling-nanotube type of wiring transmission add a new dimension to brain neuro-glial networks

Agnati

Fuxé

2014

Phil. Trans. R. Soc. B

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Two major types of intercellular communication are found in the central nervous system (CNS), namely wiring transmission (WT; point-to-point communication via private channels, e.g. synaptic transmission) and volume transmission (VT; communication in the extracellular fluid and in the cerebrospinal fluid). Volume and synaptic transmission become integrated because their chemical signals activate different types of interacting receptors in heteroreceptor complexes located synaptically and extrasynaptically in the plasma membrane. In VT, we focus on the role of the extracellular-vesicle type of VT, and in WT, on the potential role of the tunnelling-nanotube (TNT) type of WT. The so-called exosomes appear to be the major vesicular carrier for intercellular communication but the larger microvesicles also participate. Extracellular vesicles are released from cultured cortical neurons and different types of glial cells and modulate the signalling of the neuronal -glial networks of the CNS. This type of VT has pathological relevance, and epigenetic mechanisms may participate in the modulation of extracellular-vesicle-mediated VT. Gerdes and co-workers proposed the existence of a novel type of WT based on TNTs, which are straight transcellular channels leading to the formation in vitro of syncytial cellular networks found also in neuronal and glial cultures.

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Section: (B) Astrocytesmentioning

confidence: 97%

Section: (B) Astrocytesmentioning

confidence: 99%

Section: (C) Central Nervous Systemmentioning

confidence: 99%

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Extracellular-vesicle type of volume transmission and tunnelling-nanotube type of wiring transmission add a new dimension to brain neuro-glial networks

Agnati

Fuxé

2014

Phil. Trans. R. Soc. B

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“…One possible explanation for this finding is that as early endosomes and the ERC are involved in recycling of proteins between the intracellular environment and plasma membrane, their functions and position might make them more accessible to entering the membrane protrusions caused by TNT formation. However it should be noted that both the ER and Golgi have been reported inside TNT-like structures in cells of different origin 15,16 therefore this could be also cell type specific.…”

Section: Organelles Of the Recycling Pathway Enter Tntsmentioning

confidence: 99%

Prion aggregates transfer through tunneling nanotubes in endocytic vesicles

Zhu

Victoria

Marzo

et al. 2015

Prion

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ABSTRACT. Transmissible spongiform encephalopathies (TSEs) are a group of neurodegenerative diseases caused by the misfolding of the cellular prion protein to an infectious form PrP Sc . The intercellular transfer of PrP Sc is a question of immediate interest as the cell-to-cell movement of the infectious particle causes the inexorable propagation of disease. We have previously identified tunneling nanotubes (TNTs) as one mechanism by which PrP Sc can move between cells. Here we investigate further the details of this mechanism and show that PrP Sc travels within TNTs in endolysosomal vesicles. Additionally we show that prion infection of CAD cells increases both the number of TNTs and intercellular transfer of membranous vesicles, thereby possibly playing an active role in its own intercellular transfer via TNTs.

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“…[1][2][3] Recently, it was reported that TNT formation in primary rat hippocampal astrocytes and neurons was dependent on the activation of tumor suppressor protein p53 through cellular stress induction such as hydrogen peroxide (H 2 O 2 ). 4 Considering the broad effect of p53 on numerous cellular functions, 5 we here investigated whether p53 is a key protein needed for TNT formation. We first examined the effect of p53 activation on TNT formation in PC12 and OCI-AML3 (acute myeloid leukemia) cells that express wild-type p53 (p53WT).…”

mentioning

confidence: 99%