Tuning the surface microstructure of titanate coatings on titanium implants for enhancing bioactivity of implants

Wang, Hui; Lai, Yuekun; Zheng, Ruyue; Bian, Ye; Zhang, Ke‐Qin; Lin, Changjian

doi:10.2147/ijn.s75999

Cited by 24 publications

(19 citation statements)

References 40 publications

(51 reference statements)

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“…15 As the ingredient of this apatite layer is similar to the mineral phase in bone, so it can be recognized by the living body. 51 3.3.…”

Section: Resultsmentioning

confidence: 99%

“…12−14 Among these reported methods, a hydrothermal process is often utilized to functionalize the surface of biomaterials due to the facile route to prepare one-dimensional nanomaterials on the substrate despite the shape and topography. 15 Although bioactivity can be improved by the methods mentioned above, bacterial attachment will cause a deleterious effect on the result and success ratio of Ti-based implants. 16,17 In order to avoid infection, it is necessary to endow Ti-based implants with self-antibacterial ability.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antibacterial Activity of Silver Doped Titanate Nanowires on Ti Implants

et al. 2016

ACS Appl. Mater. Interfaces

105

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A nanostructured film composed of one-dimensional titanate nanowires (TNWs) was employed as a carrier of Ag nanoparticles and chitosan (CS) to improve the surface antibacterial activity and biocompatibility of titanium implants. A TNWs film was produced on a Ti substrate by an alkali hydrothermal reaction and subsequently doped by Ag nanoparticles through an ultraviolet light chemical reduction. The CS nanofilm was deposited on the Ag nanoparticles through a spin-assisted layer by layer assembly method. The results disclosed that Ag nanoparticles were successfully carried by TNWs and homogeneously distributed on the entire surface. Moreover, a CS nanofilm was also successfully deposited on the Ag nanoparticles. Antibacterial tests showed that the samples modified with a higher initial concentration of AgNO3 solution exhibited better antibacterial activity, and that a CS nanofilm could further improve the antibacterial activity of the TNWs. Cell viability and ALP tests revealed that the release of Ag(+) was detrimental for the growth, proliferation, and differentiation of MC3T3, and that CS could lower the negative effects of Ag gradually as the incubation time increased.

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“…15 As the ingredient of this apatite layer is similar to the mineral phase in bone, so it can be recognized by the living body. 51 3.3.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Silver Doped Titanate Nanowires on Ti Implants

et al. 2016

ACS Appl. Mater. Interfaces

105

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“…To this end, a bioactive, cell-friendly and artificial implant material was fabricated by researchers. 85 In this study, nanotubular structure (from titanate materials) enhanced cellular behaviors and apatite formation ability of cells on this substrate. They claim that these nanostructures made from titanate biomaterials are promising candidates for biomedical application and bone implants.…”

Section: Bone Implantsmentioning

confidence: 74%

<p>Biomedical Applications of TiO<sub>2</sub> Nanostructures: Recent Advances</p>

Jafari¹,

Mahyad²,

Hashemzadeh³

et al. 2020

IJN

253

116

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Titanium dioxide (TiO 2) nanostructures are one of the most plentiful compounds that have emerged in various fields of technology such as medicine, energy and biosensing. Various TiO 2 nanostructures (nanotubes [NTs] and nanowires) have been employed in photoelectrochemical (PEC) biosensing applications, greatly enhancing the detection of targets. TiO 2 nanostructures, used as reinforced material or coatings for the bare surface of titanium implants, are excellent additive materials to compensate titanium implants deficiencies-like poor surface interaction with surrounding tissues-by providing nanoporous surfaces and hierarchical structures. These nanostructures can also be loaded by diversified drugs-like osteoporosis drugs, anticancer and antibiotics-and used as local drug delivery systems. Furthermore, TiO 2 nanostructures and their derivatives are new emerging antimicrobial agents to overcome human pathogenic microorganisms. However, like all other nanomaterials, toxicity and biocompatibility of TiO 2 nanostructures must be considered. This review highlights recent advances, along with the properties and numerous applications of TiO 2-based nanostructure compounds in nano biosensing, medical implants, drug delivery and antibacterial fields. Moreover, in the present study, some recent advances accomplished on the pharmaceutical applications of TiO 2 nanostructures, as well as its toxicity and biocompatibility, are presented.

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“…It is still debated in literatures for the final products of Ti substrates after hydrothermal treatment in NaOH solution 32 – 34 . Several possible compositions have been proposed, including TiO 2 , Na 2 Ti 9 O 19 , Na 2 Ti 6 O 13 , Na 2 Ti 2 O 4 (OH) 2 , Na 2 Ti 3 O 7 •nH 2 O, H 2 TiO 3 O 7 , H 2 Ti 2 O 5 , H x Ti 2−x/4 □ x/4 O 4 (□ = vacancy), etc refs 32 , 34 – 40 . Bavykin et al .…”

Section: Resultsmentioning

confidence: 99%

Surface bioactivation through the nanostructured layer on titanium modified by facile HPT treatment

Guo

Jiang

Chen

et al. 2017

Sci Rep

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Facile fabrication of nanostructured surface is of great importance for the use of titanium (Ti) implants in biomedical field. In this study, a low-cost and easy-to-operate method called HPT (hydrothermal & pressure) here has been developed and used to fabricate the expected nanostructured surface on Ti substrates. The effects of experimental parameters on the morphology of Ti surface were investigated and characterized. The results indicated that by altering the hydrothermal pressure, NaOH concentration and treating time, surface nanostructure like nanopetals or nanoflakes could be formed on the surface of Ti substrates. The orthogonal experiments were conducted to demonstrate the optimized operation conditions. A formation mechanism of the nanostructured titanate layer was proposed, revealing that the nanostructured layer could be formed via a special upward and downward co-growth manner. In vitro cell culture showed that the HPT treated Ti substrates, especially the T-10 sample, could greatly enhance the cell-material interactions, i.e. the cell proliferation and differentiation, focal protein adhesion, and osteogenic factor expression. The HPT method paves a new way to modify the surface of Ti implants with better bioactivity and promising prospect for future biomedical applications.

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Tuning the surface microstructure of titanate coatings on titanium implants for enhancing bioactivity of implants

Cited by 24 publications

References 40 publications

Antibacterial Activity of Silver Doped Titanate Nanowires on Ti Implants

Antibacterial Activity of Silver Doped Titanate Nanowires on Ti Implants

<p>Biomedical Applications of TiO<sub>2</sub> Nanostructures: Recent Advances</p>

Surface bioactivation through the nanostructured layer on titanium modified by facile HPT treatment

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