Tuning the anticancer activity of a novel pro-apoptotic peptide using gold nanoparticle platforms

Akrami, Mohammad; Balalaie, Saeed; Hosseinkhani, Saman; Alipour, Mohsen; Salehi, Fahimeh; Bahador, Abbas; Haririan, Ismaeil

doi:10.1038/srep31030

Cited by 80 publications

(52 citation statements)

References 53 publications

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“…Interestingly, Akrami et al showed the possibility to exploit gold NPs as a novel anticancer platform [41]. Results of this research confirm the improvement of cell internalization of gold NPs, with higher cytotoxicity and cellular uptake for smaller NPs compared to larger nanospheres and nanorods, suggesting that anticancer effects of the selected peptides were modulated by the size and shape of the gold nanoparticles [41].…”

Section: Gold Nanoparticlessupporting

confidence: 62%

“…Further, these systems demonstrated higher antimicrobial activity and stability in serum and in the presence of non-physiological concentrations of proteolytic enzymes than soluble AMP, as well as low cytotoxicity against human cells [40]. Interestingly, Akrami et al showed the possibility to exploit gold NPs as a novel anticancer platform [41]. Results of this research confirm the improvement of cell internalization of gold NPs, with higher cytotoxicity and cellular uptake for smaller NPs compared to larger nanospheres and nanorods, suggesting that anticancer effects of the selected peptides were modulated by the size and shape of the gold nanoparticles [41].…”

Section: Gold Nanoparticlesmentioning

confidence: 99%

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Nanomedicines for the Delivery of Antimicrobial Peptides (AMPs)

et al. 2020

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Microbial infections are still among the major public health concerns since several yeasts and fungi, and other pathogenic microorganisms, are responsible for continuous growth of infections and drug resistance against bacteria. Antimicrobial resistance rate is fostering the need to develop new strategies against drug-resistant superbugs. Antimicrobial peptides (AMPs) are small peptide-based molecules of 5-100 amino acids in length, with potent and broad-spectrum antimicrobial properties. They are part of the innate immune system, which can represent a minimal risk of resistance development. These characteristics contribute to the description of these molecules as promising new molecules in the development of new antimicrobial drugs. However, efforts in developing new medicines have not resulted in any decrease of drug resistance yet. Thus, a technological approach on improving existing drugs is gaining special interest. Nanomedicine provides easy access to innovative carriers, which ultimately enable the design and development of targeted delivery systems of the most efficient drugs with increased efficacy and reduced toxicity. Based on performance, successful experiments, and considerable market prospects, nanotechnology will undoubtedly lead a breakthrough in biomedical field also for infectious diseases, as there are several nanotechnological approaches that exhibit important roles in restoring antibiotic activity against resistant bacteria.

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Section: Gold Nanoparticlessupporting

confidence: 62%

Section: Gold Nanoparticlesmentioning

confidence: 99%

Nanomedicines for the Delivery of Antimicrobial Peptides (AMPs)

et al. 2020

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“…1). Specifically, the addition of mantle-derived CO 2 and thermogenic CH 4 derived from the emplacement of the LIP 9–11 and subsequent releases of CH 4 from marine clathrates 12, 13 and terrestrial environments 14, 15 to the oceans and atmosphere are the proposed drivers of the T-OAE warming and carbon cycle perturbations. These perturbations are now recorded in sedimentary successions as pronounced negative carbon isotope excursions (CIEs), which occurred during a long-term trend to more positive carbon isotope values.…”

Section: Introductionmentioning

confidence: 99%

Evidence for rapid weathering response to climatic warming during the Toarcian Oceanic Anoxic Event

Them

Gill

Selby

et al. 2017

Sci Rep

125

129

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Chemical weathering consumes atmospheric carbon dioxide through the breakdown of silicate minerals and is thought to stabilize Earth’s long-term climate. However, the potential influence of silicate weathering on atmospheric pCO2 levels on geologically short timescales (103–105 years) remains poorly constrained. Here we focus on the record of a transient interval of severe climatic warming across the Toarcian Oceanic Anoxic Event or T-OAE from an open ocean sedimentary succession from western North America. Paired osmium isotope data and numerical modelling results suggest that weathering rates may have increased by 215% and potentially up to 530% compared to the pre-event baseline, which would have resulted in the sequestration of significant amounts of atmospheric CO2. This process would have also led to increased delivery of nutrients to the oceans and lakes stimulating bioproductivity and leading to the subsequent development of shallow-water anoxia, the hallmark of the T-OAE. This enhanced bioproductivity and anoxia would have resulted in elevated rates of organic matter burial that would have acted as an additional negative feedback on atmospheric pCO2 levels. Therefore, the enhanced weathering modulated by initially increased pCO2 levels would have operated as both a direct and indirect negative feedback to end the T-OAE.

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“…AuNPs have been extensively used as a core for coating targeting peptides . Lee and co‐workers attached RGD (targets inflammation) to Au half‐shell nanoparticles containing methotrexate (MTX, most widely used RA therapeutic) as an improved photo‐/chemotherapy agent for the treatment of rheumatoid arthritis (RA) in collagen‐induced arthritic (CIA) mice.…”

Section: Peptide‐conjugated Nanomaterialsmentioning

confidence: 99%

Bio‐Conjugated Advanced Materials for Targeted Disease Theranostics

Kwon

Yan

et al. 2020

Adv Funct Materials

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Human beings are “machines” that use endogenously produced biomolecules as “components” in signaling and for the maintenance of the body. These biomolecules consist of proteins, nucleic acids, and carbohydrates, which can either be extracted from biological substrates or synthesized by chemical/biochemical methods. These biomolecules have the ability to recognize/interact with other biomolecules that are overexpressed in disease cells. For targeted theranostics, strategies to chemically incorporate these natural biomolecules with advanced materials to treat human diseases by imaging‐guided drug delivery or photodynamic/photothermal therapy are proposed, with improved biocompatibility. Herein, recent research on construction of quantum dots, nanoparticles, and 2D material platforms decorated with antibodies, peptides, nucleic acid aptamers, carbohydrates, and folic acid for targeted diagnosis and treatment are summarized and discussed. In addition, the various strategies required to construct effective functional materials for targeted cancer therapy are highlighted. The hope is that this review can inspire and guide those that are interested in the field of biomedicine to rationally design and develop new target‐based theranostic materials.

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Tuning the anticancer activity of a novel pro-apoptotic peptide using gold nanoparticle platforms

Cited by 80 publications

References 53 publications

Nanomedicines for the Delivery of Antimicrobial Peptides (AMPs)

Nanomedicines for the Delivery of Antimicrobial Peptides (AMPs)

Evidence for rapid weathering response to climatic warming during the Toarcian Oceanic Anoxic Event

Bio‐Conjugated Advanced Materials for Targeted Disease Theranostics

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