Tuning Photosensitized Singlet Oxygen Generation Efficiency of Novel Aza-BODIPY Dyes

Adarsh, Nagappanpillai; Avirah, Rekha R.; Ramaiah, Danaboyina

doi:10.1021/ol200572p

Cited by 43 publications

(39 citation statements)

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“…Tetraiodinated BODIPY 28 showed about 87% of singlet oxygen quantum yield compared to Rose Bengal (71%). The introduction of iodine atoms in the pyrrole ring of aza-BODIPY derivatives also improved the intersystem crossing efficiency, which was prepared by reacting 29 (long wavelength) with 4.5 equiv of N-iodosuccinimide in a 3 : 1 mixture of chloroform/ acetic acid at 25 uC for 10 h. 89,90 …”

Section: E Structural Modification Of Bodipy-based Photosensitizers mentioning

confidence: 99%

Boron dipyrromethene (BODIPY)-based photosensitizers for photodynamic therapy

2012

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Photodynamic therapy (PDT) has shown promise as an effective treatment modality for cancers and other localized diseases, such as age-related macular degeneration and actinic keratosis. PDT relies on light, photosensitizer and oxygen as elements in its mechanism of action. BODIPY photosensitizers that have been under extensive study over the past decade have been demonstrated as a new class of photosensitizers. In this review, we attempt to summarize the decade-long study of BODIPY-based photosensitizers. We provide an overview of the superior photophysical properties possessed by BODIPY-based agents and the various synthetic strategies employed that have led to improved and selective and/or targeted photosensitizers. A. IntroductionPhotodynamic therapy (PDT) is an effective and approved regime for the treatment of certain types of cancers and precancerous inductions, age-related macular degeneration and actinic keratosis. 1-4 It has also been explored for other diseases, such as localized infections, dermatological and cardiovascular illnesses and wound healing. 5-7 Three elements are important components for effective photodynamic activity: light, oxygen and a photosensitizer (PS). BODIPY (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene)-based and its aza analogue (Fig. 1) PSs (PSs) are a new class of PSs retaining characteristics of fluorescent BODIPY dyes such as excellent optical properties and synthetic versatility. 8-10 This review seeks to summarize and discuss recent achievements in BODIPY-based PSs for the application of oncologic and antimicrobial PDT. B. Three key elements of PDTPDT operates by a tripartite modality involving light, a PS and oxygen. A PS is administered and then the treatment site (e.g. ; Tel: +1 405 271 6593x47473 { Electronic Supplementary Information (ESI) available: a summary table of BODIPY-based photosensitizers: structures, optical properties, light dosimetry, cell line and drug doses. See

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Section: E Structural Modification Of Bodipy-based Photosensitizers mentioning

confidence: 99%

Boron dipyrromethene (BODIPY)-based photosensitizers for photodynamic therapy

2012

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“…In the case of oxygen molecules, an additional mechanism related to Förster resonant energy transfer (FRET) can also play an important role remarkably influencing PL behaviour of silicon nanostructures. It has been shown that effective generation of singlet oxygen can be provoked by external sensitizers like dye molecules [Awuah 2011, Adarsh 2010Shi 2006;DeRosa 2002]. Moreover, silicon nanostructures can also play role of effective photosensitizers of singlet oxygen generation.…”

Section: Experimental Methodsmentioning

confidence: 99%

Unique Applications of Optical Properties of Silicon Nanostructures

Ryabchikov¹

2019

MM SJ

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Silicon nanostructures can be prepared by different methods that considerably change their optical properties depending on experimental conditions. They are also very sensitive to molecular environment and external influences that can be used for multiple applications in different areas. Silicon nanostructures prepared by laser ablation show large perspectives for molecular sensing and biomedical applications. In this paper, an overview of optical properties of silicon nanostructures with focus on nanoparticles prepared by ultrafast laser ablation in liquids is provided. It is shown that they reveal wide prospects for applications in nanobiomedicine and their unique characteristics can be significantly enhanced due to laser-induced metal incorporation. Metal inclusions lead to appearance of plasmonic properties in semiconductor nanomaterials that can be applied for molecule detection using surface enhancing of optical response.

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“…S8, ESI †) and F is the absorption correction factor, which is given by F = 1-10 −OD (OD at the irradiation wavelength). 41 Determination of the minimum inhibitory concentration (MIC) 42 The…”

Section: Measurement Of Singlet Oxygen Production Efficiencymentioning

confidence: 99%