Tuning particle inertial separation in sinusoidal channels by embedding periodic obstacle microstructures

Abstract

Inertial microfluidics functions solely based on fluid dynamics at relatively high flow speed. Thus, channel geometry is the critical design parameter that contributes to the performance of the device. Four...

High-recovery sorting of cancer cells from whole blood via periodic-focusing inertial microchip

“…Lu et al and Cha et al first reported periodic contraction structures to improve inertial sorting. 51,53 We have modified this approach to isolate small-diameter cancer cells (A549 lung cancer cells) from blood samples and breast cancer cells from blood plasma. We report an improvement in cell recovery and separation enrichment when compared to extant approaches.…”

Advances in Microfluidics: Technical Innovations and Applications in Diagnostics and Therapeutics

“…The fully automated and portable platform can harvest up to 0.4 million of intact WBCs from 50 μL of human peripheral blood. More complex channel geometries beyond the classical straight or spiral layout may lead to improved inertial-based separation techniques . Embedding periodic concave and convex obstacle microstructures in sinusoidal channels can significantly enhance the Dean flow and tune the flow range for particle inertial focusing and separation.…”

Numerical Investigation of Flow Patterns and Mixing Characteristics in a 3D Micromixer with Helical Elements over Wide Reynolds Numbers

“…[4] For instance, curved microchannels take advantage of inertial force to create a pressure gradient normal to the main flow, triggering Dean flow to enhance the convection effect. [14][15][16] Various curved microchannels, including serpentine channel, [17][18][19] helical channel, [20][21][22] and twisted channel, [23] were usually designed into passive micromixers. Besides, through integrating different microstructures, including herringbone structure, [24][25][26] Tesla structure, [4,27] barriers on the channel, [9,28,29] and cross-linked channel in microchannels, [30,31] the fluid inside could be folded, split, stretched, enlarged or recombined to increase the interfacial contact area and then induce chaotic advection.…”