Tuning cell adhesion on polymeric and nanocomposite surfaces: Role of topography versus superhydrophobicity

Zangi, Sepideh; Hejazi, Iman; Seyfi, Javad; Hejazi, Ehsan; Khonakdar, Hossein Ali; Davachi, Seyed Mohammad

doi:10.1016/j.msec.2016.03.021

Cited by 36 publications

(28 citation statements)

References 27 publications

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“…After in vitro cell culture for 6 days, the cells showed varying degrees of adhesion to these four surfaces, thereby confirming that surface morphology influences cell adhesion. Similar results were obtained on PP surfaces with different topographies and moisture contents . In this way, by controlling the surface morphology within specific ranges, it is possible to promote cell adhesion.…”

Section: Introductionsupporting

confidence: 76%

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PCL films of varying porosity influence ICAM‐1 expression of HUVECs

Shen

et al. 2016

J Biomedical Materials Res

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Here, we investigate the relationship between the expression of intercellular adhesion molecule-1 (ICAM-1) and the adhesion of human umbilical vein endothelial cells (HUVECs) on a poly-ε-caprolactone (PCL) film with micropores of different pore sizes. The results showed that surface hydrophilicity increased with larger pore sizes, while surfaces became less hydrophilic as the pore size decreased. The ability for adhesion and proliferation of HUVECs on surfaces with larger pore sizes was enhanced as compared with that of surfaces with smaller pore sizes or a flat film. Furthermore, levels of mICAM-1 were increased and sICAM-1 decreased as a function of increasing pore size. These findings demonstrate that film surfaces with larger pore sizes may promote cell adhesion and proliferation and lead to increases in expression of mICAM-1. Thus, we conclude that the pore size of the material's surface exerts a significant impact on the expression of adhesion molecules, the expression of which can represent an important new marker for investigating cell-surface adhesion and proliferation. Moreover, as elevated levels of sICAM-1 are associated with conditions such as inflammation, thrombosis, cerebral infarct and other diseases in vivo, it may serve as an early-warning risk marker when using medical biomaterials. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2775-2784, 2016.

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Section: Introductionsupporting

confidence: 76%

“…Similar results were obtained on PP surfaces with different topographies and moisture contents. 34 In this way, by controlling the surface morphology within specific ranges, it is possible to promote cell adhesion.…”

Section: Introductionmentioning

confidence: 99%

PCL films of varying porosity influence ICAM‐1 expression of HUVECs

Shen

et al. 2016

J Biomedical Materials Res

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“…The MTT-quantified adhesion test reports the number of cells that adheres to the composite and remains viable. The SEM-quantified adhesion test offers insight into the location and morphology of adherent cells [32].The results of the MTT-quantified adhesion test quantified showed a significant decrease in the number of viable cells that were exposed directly to the COF and CDT composites compared with the NC in both experimental periods (Fig. 5).…”

Section: Resultsmentioning

confidence: 97%

Composites Produced from Natural Rubber and Chrome-Tanned Leather Wastes: Evaluation of their In Vitro Toxicological Effects for Application in Footwear and Textile Industries

et al. 2017

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“…As an approach to rectify these problems many attempts have been employed to change the structure of surface chemicals to promote cell adhesion and proliferation as achieved with the use of layer by layer or surface grafting . However, for a woven fabric, such as polyethylene glycol terephthalate (PET), the structural parameters seem to exert a greater impact upon cell adhesion than that of the chemical structure . Due to the special warp/weft weaving structure of woven fabrics, their surfaces lack the flat uniformity that can be achieved with polymeric films or electrospinning nanofibers films; a condition that results from interlacing among yarns where the pore size was also larger than that on films.…”

Section: Introductionmentioning

confidence: 99%

Control of weft yarn or density improves biocompatibility of PET small diameter artificial blood vessels

Guan

et al. 2017

J Biomed Mater Res

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Polyethylene glycol terephthalate (PET) fabrics with woven structures have proved to be quite effective for use on large diameter artificial blood vessels. However, their use within small-diameter artificial blood vessels has been associated with poor long-term patency, a problem resulting from slow endothelialization on PET and an over hyperplasia of smooth muscle cells. Previous research from our laboratory has revealed that ICAM-1 can be used as a marker to investigate cell adhesion, an effect which was closely associated with cell behavior on the surface of polycaprolactone (PCL) films. Moreover, we found that the coarseness or pore size of the surface exerts considerable influence on cell adhesion and proliferation on PCL films. In this study, we successfully fabricated six types of PET woven fabrics with varying gradients of tightness and porosities. Levels of ICAM-1 expression (membrane ICAM-1 & soluble ICAM-1) were then determined in these woven fabrics. Our results show that increased levels of mICAM-1 and decreased levels of sICAM-1 expression were obtained in HUVECs seeded on these six samples. These findings indicate that cell adhesion and proliferation on fabric surfaces were strongly influenced by their structural parameters, in particular the initial adhesion between the cell and fabric surface. In addition, we also found that extracellular matrix adhesion tends to prefer flat and tight surfaces, which promotes cell-cell and cell-matrix interactions, as well as the endothelialization on the surface of PET fabrics. These findings provide some novel insights with regard to the design and application of small-diameter artificial blood vessels. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 954-964, 2018.

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Tuning cell adhesion on polymeric and nanocomposite surfaces: Role of topography versus superhydrophobicity

Cited by 36 publications

References 27 publications

PCL films of varying porosity influence ICAM‐1 expression of HUVECs

PCL films of varying porosity influence ICAM‐1 expression of HUVECs

Composites Produced from Natural Rubber and Chrome-Tanned Leather Wastes: Evaluation of their In Vitro Toxicological Effects for Application in Footwear and Textile Industries

Control of weft yarn or density improves biocompatibility of PET small diameter artificial blood vessels

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