Tuneable semi-synthetic network alginate for absorptive encapsulation and controlled release of protein therapeutics

Chan, Ariel W.; Neufeld, Ronald J.

doi:10.1016/j.biomaterials.2010.07.111

Cited by 96 publications

(59 citation statements)

References 36 publications

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“…In a recent study, semi-synthetic network alginate polymer (SNAP) hydrogels were prepared by Chan et al [92] by reacting native alginate with di-aldehyde, forming acetal-linked 3D hydrogel network that were fine tuned to get the desired pore sizes of 40 and 80 nm. These devices exhibited near zero order release of insulin in 2-3 h and the release rate increased with increasing molecular size of the biopolymer.…”

Section: Miscellaneous Hydrogelsmentioning

confidence: 99%

Polymeric hydrogels for oral insulin delivery

Chaturvedi¹,

Ganguly²,

Nadagouda³

et al. 2013

Journal of Controlled Release

228

154

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Section: Miscellaneous Hydrogelsmentioning

confidence: 99%

Polymeric hydrogels for oral insulin delivery

Chaturvedi¹,

Ganguly²,

Nadagouda³

et al. 2013

Journal of Controlled Release

228

154

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“…Alginate, an anionic mucoadhesive polysaccharide consisting of various ratios of b-D-mannuronopyranosyl and a-L-guluronopyranosyl units linked by (1!4)-O-glycosidic bonds, has always been used for preparing microparticles (Chan & Neufeld, 2010). It shows a property of mild gelformation by ionically cross-linked with multivalent cations, such as calcium ions, thus enabling drug retention within the gel matrix (Sarmento et al, 2007a,b).…”

Section: Alginate Derivativesmentioning

confidence: 99%

A review of biodegradable polymeric systems for oral insulin delivery

Luo

Xiong

Tian³

et al. 2015

Drug Delivery

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Currently, repeated routine subcutaneous injections of insulin are the standard treatment for insulin-dependent diabetic patients. However, patients' poor compliance for injections often fails to achieve the stable concentration of blood glucose. As a protein drug, the oral bioavailability of insulin is low due to many physiological reasons. Several carriers, such as macromolecules and liposomes have been used to deliver drugs in vivo. In this review article, the gastrointestinal barriers of oral insulin administration are described. Strategies for increasing the bioavailability of oral insulin, such absorption enhancers, enzyme inhibitors, enteric coatings are also introduced. The potential absorption mechanisms of insulin-loaded nanoparticles across the intestinal epithelium, including intestinal lymphatic route, transcellular route and paracellular route are discussed in this review. Natural polymers, such as chitosan and its derivates, alginate derivatives, g-PGA-based materials and starch-based nanoparticles have been exploited for oral insulin delivery; synthetic polymers, such as PLGA, PLA, PCL and PEA have also been developed for oral administration of insulin. This review focuses on recent advances in using biodegradable natural and synthetic polymers for oral insulin delivery along with their future prospects.

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“…The use of microbeads as sorbents has been studied with polymers such as alginate and dextran (Chan & Neufeld, 2010;Chan, Yim, Phan, Mansa, & Ravindra, 2010;Schillemans, Verheyen, Barendregt, Hennink, & Van Nostrum, 2011), but limited studies using whey protein microbeads as sorbents have been conducted (Déat-Lainé et al, 2013). The sorption method has many advantages including no diffusional loss of the bioactive during crosslinking and the gentle conditions used which avoid high heat and shear.…”

Section: Introductionmentioning

confidence: 99%