With rapidly developing technological advances and increasing commercialization, optical frequency combs are beginning to see use in chemical laboratories around the world. These light sources allow chemists to collect high-resolution, multiplexed direct absorption spectra in a fraction of the laboratory time required by more conventional methods. Broadband coupling of combs into high-finesse optical cavities continues to break new ground in the sensitivity of both frequency-and time-resolved spectroscopies. Analytical sensing applications are also undergoing a burst of activity as comb systems become miniaturized, turn-key, and more robust in rugged environments. In this Chapter, we introduce frequency comb spectroscopy and survey its recent applications to molecular spectroscopy and dynamics, chemical reaction kinetics, and sensing.