Tunable thermo-responsive hydrogels: Synthesis, structural analysis and drug release studies

Cirillo, Giuseppe; Spataro, Tania; Curcio, Manuela; Spizzirri, Umile Gianfranco; Nicoletta, Fiore Pasquale; Picci, Nevio; Iemma, Francesca

doi:10.1016/j.msec.2014.12.045

Cited by 42 publications

(19 citation statements)

References 38 publications

(45 reference statements)

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“…Banerjee et al have also reported anomalous diffusion kinetics for release of sodium diclofenac from sodium carboxymethyl cellulose and PVA matrix . The retardation in the drug release can be ascribed to radiation induced increase in the crosslinking density . Similar effect of crosslinking density was observed in the 2‐hydroxypropyltrimethyl ammonium chloride chitosan/Fe 3 O 4 /halloysite nanotubes microspheres used for controlled release of ofloxacin .…”

Section: Resultsmentioning

confidence: 74%

Graphene reinforced radiation crosslinked polyvinyl alcohol/carboxymethyl cellulose nanocomposites for controlled drug release

et al. 2015

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This study reports development of graphene reinforced nanocomposites of carboxymethyl cellulose and polyvinyl alcohol for controlled drug release applications. The nanocomposites were synthesized through solution blending coupled with sonication assisted dispersion. The matrices were crosslinked to different extent by imparting different high energy radiation doses. The elastic modulus of the polymer nanocomposites increased by fourfold with the increase in graphene content from 1 to 3 wt% with no further significant change in elastic modulus at higher graphene content. The crystalline content did not change with addition of graphene and was 40% for all nanocomposites. Addition of 3 wt% graphene marginally increased the time for 60% drug release (T 60 ). However, T 60 increased by 100% with an increase in radiation dose from 25 to 150 kGy, suggesting absorbed radiation dose to be a critical factor for graphene based nanocomposites for controlled drug release applications. POLYM. COMPOS., 38:E74-E80, 2017.

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Section: Resultsmentioning

confidence: 74%

Graphene reinforced radiation crosslinked polyvinyl alcohol/carboxymethyl cellulose nanocomposites for controlled drug release

et al. 2015

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“…Thermo-responsive materials have greatly impacted research into actuating materials with many possible applications such as drug delivery [40,43,44], chromatography techniques [45], biomedicine [46][47][48] being explored. The thermo-response arises from a shift in the hydration forces which occur between the polymer chains and the aqueous medium, at temperatures close to the lower critical solution temperature (LCST) of a polymer [49].…”

Section: Thermo-induced Actuationmentioning

confidence: 99%

Stimuli-Controlled Fluid Control and Microvehicle Movement in Microfluidic Channels

Dunne¹,

Francis²,

Delaney³

et al. 2017

Reference Module in Materials Science and Materials Engineering

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Integration of stimuli-responsive materials into microfluidic systems provides a means to locally manipulate flow at the microscale, in a non-invasive manner, while also reducing system complexity. In recent years, several modes of stimulation have been applied, including electrical, magnetic, light and temperature, among others. To achieve remote control of flow in microfluidics using external stimulation, two main approaches have emerged in the recent years: 1. Control of flow through stimuli-induced actuation of microfluidic components (valves, pumps, mixers, flow sorters), most often fabricated from soft polymeric materials; 2. Stimuli-controlled manipulation of discrete micrometer-sized "vehicles" (droplets, beads, Janus particles, etc.) through localized induced changes in wettability or surface tension.The focus of this chapter will be to identify and compare the similarities and underlying mechanisms employed in the current state of the art research in stimuli-controlled fluid control and micro-vehicle movement fields. It will also endeavor to propose possible directions for the evolution of these areas of research.

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“…Positive temperature-responsive hydrogels undergo sol-gel transition as the temperature increases above critical solution temperature (CST) [63][64][65][66] . Negative temperature-responsive hydrogels gel at the temperature below the CST [67,68] . Censis et al evaluated the suitability of a biodegradable, photopolymerizable and thermosensitive A-B-A triblock copolymer hydrogel as a synthetic extracellular matrix for engineering tissues by means of three-dimensional fiber deposition.…”

Section: Temperature Responsive Hydrogelmentioning

confidence: 99%

Smart hydrogels for 3D bioprinting

Wang¹,

Lee²,

Yeong³

2015

ijb

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Hydrogels are 3D networks that have a high water content. They have been widely used as cell carriers and scaffolds in tissue engineering due to their structural similarities to the natural extracellular matrix. Among these, "Smart" hydrogels refer to a group of hydrogels that is responsive to various external stimuli such as pH, temperature, light, electric, and magnetic field. Combining the potential of 3D printing and smart hydrogels is an exciting new paradigm in the fabrication of a functional 3D tissue. In this article, we provide a state-of-the-art review on smart hydrogels and bioprinting. We identify the critical material properties needed for the most commonly used bioprinting techniques, namely extrusion-based, inkjet-based, and laser-based techniques. The latest progress in different smart hydrogel systems and their applications in bioprinting are presented. The challenges of printing these hydrogel systems are also highlighted. Lastly, we present the potentials and the future perspectives of smart hydrogels in 3D bioprinting.

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Tunable thermo-responsive hydrogels: Synthesis, structural analysis and drug release studies

Cited by 42 publications

References 38 publications

Graphene reinforced radiation crosslinked polyvinyl alcohol/carboxymethyl cellulose nanocomposites for controlled drug release

Graphene reinforced radiation crosslinked polyvinyl alcohol/carboxymethyl cellulose nanocomposites for controlled drug release

Stimuli-Controlled Fluid Control and Microvehicle Movement in Microfluidic Channels

Smart hydrogels for 3D bioprinting

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