Tunable, monochromatic X‐rays: An enabling technology for molecular/cellular imaging and therapy

Carroll, Frank E.

doi:10.1002/jcb.10632

Cited by 34 publications

(16 citation statements)

References 31 publications

(28 reference statements)

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“…Theoretically, tumor dose enhancement upon photon activation is achieved through the irradiation of high-Z elements at their K-edge absorption energy, leading to emission of Auger electrons and x-rays photons, which results in the release of a large amount of energy in their immediate vicinity [9,16,21,22]. Our previous radiosensitization experiment on a tumor cell given FeO NP with high energy LINAC X-rays showed much less dose enhancement effect (only 10%) compared to tuned monochromatic X-rays irradiation (50–70%) [17].…”

Section: Discussionmentioning

confidence: 99%

Photon activated therapy (PAT) using monochromatic Synchrotron x-rays and iron oxide nanoparticles in a mouse tumor model: feasibility study of PAT for the treatment of superficial malignancy

et al. 2012

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BackgroundX-rays are known to interact with metallic nanoparticles, producing photoelectric species as radiosensitizing effects, and have been exploited in vivo mainly with gold nanoparticles. The purpose of this study was to investigate the potential of sensitizing effect of iron oxide nanoparticles for photon activated therapy.MethodsX-rays photon activated therapy (PAT) was studied by treating CT26 tumor cells and CT26 tumor-bearing mice loaded with 13-nm diameter FeO NP, and irradiating them at 7.1 keV near the Fe K-edge using synchrotron x-rays radiation. Survival of cells was determined by MTT assay, and tumor regression assay was performed for in vivo model experiment. The results of PAT treated groups were compared with x-rays alone control groups.ResultsA more significant reduction in viability and damage was observed in the FeO NP-treated irradiated cells, compared to the radiation alone group (p < 0.04). Injection of FeO NP (100 mg/kg) 30 min prior to irradiation elevated the tumor concentration of magnetite to 40 μg of Fe/g tissue, with a tumor-to-muscle ratio of 17.4. The group receiving FeO NP and radiation of 10 Gy showed 80% complete tumor regression (CTR) after 15–35 days and relapse-free survival for up to 6 months, compared to the control group, which showed growth retardation, resulting in 80% fatality. The group receiving radiation of 40 Gy showed 100% CTR in all cases irrespective of the presence of FeO NP, but CTR was achieved earlier in the PAT-treated group compared with the radiation alone group.ConclusionsAn iron oxide nanoparticle enhanced therapeutic effect with relatively low tissue concentration of iron and 10 Gy of monochromatic X-rays. Since 7.1 keV X-rays is attenuated very sharply in the tissue, FeO NP-PAT may have promise as a potent treatment option for superficial malignancies in the skin, like chest wall recurrence of breast cancer.

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Section: Discussionmentioning

confidence: 99%

Photon activated therapy (PAT) using monochromatic Synchrotron x-rays and iron oxide nanoparticles in a mouse tumor model: feasibility study of PAT for the treatment of superficial malignancy

et al. 2012

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“…As far as the medical science applications are concerned an important benefit of such sources is given in imaging, by the development of the phase contrast method. Other applications are possible, for example, in static and dynamic imaging [6,7], 3D compressionless mammography [8], broncography, catheterless coronary arteries angiography [9] and in the K-edge radiography and therapy. An important feature of Compton sources is the tunability to specific X-ray energy obtainable by varying the energy of the electron beam (quadratic dependence) or the wavelength of the impinging laser (linear dependence).…”

Section: Uvx 2010mentioning

confidence: 99%

ThomX: A high flux compact X ray source

Bruni

Artemiev

Roux

et al. 2011

UVX 2010 - 10e Colloque Sur Les Sources Cohérentes Et Incohérentes UV, VUV Et X ; Applications Et Développements Récents

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Abstract. In the field of application of X-rays, there is a strong need for high brightness, tunable beam. The synchrotron radiation sources meet this demand, but the access time is limited, and they are large and expensive facilities. In this framework, we develop a compact monochromatic high flux X-ray source. The principle lies in obtaining X-ray by Compton backscattering of photons by relativistic electrons. This facility is relatively compact (about 70 m 2 ) to be installed directly in a scientific laboratory, a hospital or an art museum. The backscattered photons are in the range of multi-keV energy, determined by the energy of the electrons and photons. Since there is a correlation between emission angle and energy of scattered photons, the spectral bandwidth of scattered photons can be controlled by simple collimation. The paper presents the ThomX X-ray source consisting of a 50 MeV small storage ring and a laser coupled to a high gain Fabry Perot cavity.

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“…There is presently a number of laser-electron gamma and X-ray sources that are in operation or in the design stage [7]- [10]. They are designed for experiments in nuclear physics, generation of femtosecond X-ray pulses, medical imaging, protein crystallography etc.…”

Section: Basics and Approachmentioning

confidence: 99%

Proposal of a compact repetitive dichromatic x-ray generator with millisecond duty cycle for medical applications

Gorbunkov¹,

Tunkin²,

Bessonov³

et al. 2005

SPIE Proceedings

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Main practical applications of X-rays lie in the important for the society fields of medical imaging, custom, transport inspection and security. Scientific applications besides of fundamental research include material sciences, biomicroscopy, and protein crystallography. Two types of X-ray sources dominate now: conventional tubes and electron accelerators equipped with insertion devices. The first are relatively cheap, robust, and compact but have low brightness and poorly controlled photon spectrum. The second generate low divergent beams with orders of magnitude higher brightness and well-controlled and tunable spectrum, but are very expensive and large in scale. So accelerator based Xray sources are mainly still used for scientific applications and X-ray tubes -in commercial equipment. The latter motivated by the importance for the society made an impressive progress during last decades mostly due to the fast developments of radiation detectors, computers and software used for image acquisition and processing. At the same time many important problems cannot be solved without radical improvement of the parameters of the X -ray beam that in commercial devices is still provided by conventional X -ray tubes.Therefore there is a quest now for a compact and relatively cheap source to generate X-ray beam with parameters and controllability approaching synchrotron radiation. Rapid developments of lasers and particle accelerators resulted in implementation of laser plasma X-ray sources and free electron lasers for various experiments requiring high intensity, shrt duration and monochromatic X-ray radiation. Further progress towards practical application is expected from the combination of laser and particle accelerator in a single unit for effic ient X-ray generation. BASICS AND APPROACHThirty years development of laboratory X-ray lasers allowed to reach ~0.1 keV photon energy of coherent X-ray beams in a repetitive mode. Further scaling shows feasibility of ~0.3 keV coherent radiation in such type of devices. However their average power is still insufficient for many practical applications including medicine and inspection. Much higher power is expected to obtain in future free electron lasers. However according to existing projects their size and cost will prevent wide spreading of this kind of machines. In this project a compact repetitive dichromatic X-ray source (see Fig. 1a) based on novel laser and electron accelerator systems is proposed for medical applications. X-rays originate from Thomson scattering of counter propagating laser and electron beams. Such a "laser-accelerator" approach is very flexible in providing an X-ray beam with properties required by numerous medical applications.As a typical example, requiring a high power X -ray beam, coronary angiography is considered here, which is the leading method of imaging of coronary arteries. More than one million coronary angiography diagnostic procedures per year are applied in the US to evaluate the patient's conditions and choose the best heart treatment s...

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Tunable, monochromatic X‐rays: An enabling technology for molecular/cellular imaging and therapy

Cited by 34 publications

References 31 publications

Photon activated therapy (PAT) using monochromatic Synchrotron x-rays and iron oxide nanoparticles in a mouse tumor model: feasibility study of PAT for the treatment of superficial malignancy

Photon activated therapy (PAT) using monochromatic Synchrotron x-rays and iron oxide nanoparticles in a mouse tumor model: feasibility study of PAT for the treatment of superficial malignancy

ThomX: A high flux compact X ray source

Proposal of a compact repetitive dichromatic x-ray generator with millisecond duty cycle for medical applications

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