Tunability of Size and Magnetic Moment of Iron Oxide Nanoparticles Synthesized by Forced Hydrolysis

Sutens, Ben; Swusten, Tom; Zhong, Kuo; Jochum, J.; Bael, M. J. Van; Eycken, Erik V. Van der; Brullot, Ward; Bloemen, Maarten; Verbiest, Thierry

doi:10.3390/ma9070554

Cited by 15 publications

(9 citation statements)

References 34 publications

(46 reference statements)

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“…The M-H loops of the both sets of particles are shown in Figure 6 . Consistent with previously published data, the larger particles exhibited higher saturation magnetization, likely due to better developed crystallinity [ 37 , 38 , 39 ]. Both 100 nm and 225 nm particles saturated at approximately 1000 Oe applied field.…”

Section: Resultssupporting

confidence: 91%

Ultrasensitive Magnetic Nanoparticle Detector for Biosensor Applications

Liang

Chang

Qiu

et al. 2017

Sensors

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Ta/Ru/Co/Ru/Co/Cu/Co/Ni80Fe20/Ta spin-valve giant magnetoresistive (GMR) multilayers were deposited using UHV magnetron sputtering and optimized to achieve a 13% GMR ratio before patterning. The GMR multilayer was patterned into 12 sensor arrays using a combination of e-beam and optical lithographies. Arrays were constructed with 400 nm × 400 nm and 400 nm × 200 nm sensors for the detection of reporter nanoparticles. Nanoparticle detection was based on measuring the shift in high-to-low resistance switching field of the GMR sensors in the presence of magnetic particle(s). Due to shape anisotropy and the corresponding demag field, the resistance state switching fields were significantly larger and the switching field distribution significantly broader in the 400 nm × 200 nm sensors as compared to the 400 nm × 400 nm sensors. Thus, sensor arrays with 400 nm × 400 nm dimensions were used for the demonstration of particle detection. Detection of a single 225 nm Fe3O4 magnetic nanoparticle and a small number (~10) of 100 nm nanoparticles was demonstrated. With appropriate functionalization for biomolecular recognition, submicron GMR sensor arrays can serve as the basis of ultrasensitive chemical and biological sensors.

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Section: Resultssupporting

confidence: 91%

Ultrasensitive Magnetic Nanoparticle Detector for Biosensor Applications

Liang

Chang

Qiu

et al. 2017

Sensors

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“…This corresponds to a 5-fold and 8-fold increase in magnetization, when comparing based on nanoparticle mass and iron mass, respectively. These values also exceed the magnetic saturation of 66 emu/g reported for 20 nm SPIONs [32]. Interestingly, previous studies showing modification of magnetite nanoparticles usually imply a reduction of their magnetization, compared with pure SPIONs [13,[33][34][35][36].…”

Section: Magnetic and Optical Propertiesmentioning

confidence: 48%

“…Studies have shown that particle size can impact the effectiveness of Prussian blue in treatment of heavy metal poisoning [55,56]. Moreover, it has been shown that the size and shape of single-domain particles can affect their magnetic properties, which may influence their behavior in magnetic manipulation and heating applications [32,[57][58][59][60].…”

Section: Discussionmentioning

confidence: 99%

Photomagnetic Prussian blue nanocubes: Synthesis, characterization, and biomedical applications

Dumani

Cook

Kubelick

et al. 2020

Nanomedicine: Nanotechnology, Biology and Medicine

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Nanoparticles play an important role in biomedicine. We have developed a method for sizecontrolled synthesis of photomagnetic Prussian blue nanocubes (PBNCs) using superparamagnetic iron oxide nanoparticles (SPIONs) as precursors. The developed PBNCs have magnetic and optical properties desired in many biomedical diagnostic and therapeutic applications. Specifically, the size-tunable photomagnetic PBNCs exhibit high magnetic saturation, strong optical absorption with a peak at approximately 700 nm, and superior photostability. Our studies demonstrate that PBNCs can be used as MRI and photoacoustic imaging contrast agents in vivo. We also showed the utility of PBNCs for labeling and magnetic manipulation of cells. Dual magnetic and optical properties, together with excellent biocompatibility, render PBNCs an attractive contrast agent for both diagnostic and therapeutic applications. The use SPIONs as precursors for PBNCs provides flexibility and allows researchers to design theranostic agents according to required particle size, optical, and magnetic properties.

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“…Therefore, there has been a continual desire to develop more effective SPIONs. The magnetic moment of a particle is typically proportional to its size (Rosensweig, 2002;Sutens et al, 2016); therefore, numerous strategies have been developed to increase SPION size. For example, seed growth is a well-studied method of gradually growing monodisperse SPIONs up to 20 nm in diameter (S. Sun et al, 2004); unfortunately, although this process produces very monodisperse particles, the gradual size increase in multiple steps lengthens synthesis time.…”

Section: Magnetic Nanoparticlesmentioning

confidence: 99%

Use of magnetic fields and nanoparticles to trigger drug release and improve tumor targeting

Liu

Jang

Issadore

et al. 2019

WIREs Nanomed Nanobiotechnol

128

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Drug delivery strategies aim to maximize a drug's therapeutic index by increasing the concentration of drug at target sites while minimizing delivery to off‐target tissues. Because biological tissues are minimally responsive to magnetic fields, there has been a great deal of interest in using magnetic nanoparticles in combination with applied magnetic fields to selectively control the accumulation and release of drug in target tissues while minimizing the impact on surrounding tissue. In particular, spatially variant magnetic fields have been used to encourage accumulation of drug‐loaded magnetic nanoparticles at target sites, while time‐variant magnetic fields have been used to induce drug release from thermally sensitive nanocarriers. In this review, we discuss nanoparticle formulations and approaches that have been developed for magnetic targeting and/or magnetically induced drug release, as well as ongoing challenges in using magnetism for therapeutic applications. This article is categorized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Emerging Technologies Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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Tunability of Size and Magnetic Moment of Iron Oxide Nanoparticles Synthesized by Forced Hydrolysis

Cited by 15 publications

References 34 publications

Ultrasensitive Magnetic Nanoparticle Detector for Biosensor Applications

Ultrasensitive Magnetic Nanoparticle Detector for Biosensor Applications

Photomagnetic Prussian blue nanocubes: Synthesis, characterization, and biomedical applications

Use of magnetic fields and nanoparticles to trigger drug release and improve tumor targeting

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