Tumours of the Moll's glands.

Ni, Chuo; Wagoner, Michael D.; Kieval, Shalom; Albert, Daniel M.

doi:10.1136/bjo.68.7.502

Cited by 36 publications

(22 citation statements)

References 9 publications

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“…In the case reported by Futrell et al ., 3 the tumor showed regional lymph node metastasis 9 months after the excision of the primary tumor. In the case reported by Ni et al 4 . (case 3), the tumor showed a striking perineural invasion and it developed a local recurrence and lymph node metastasis 1 year after the operation.…”

Section: Discussionmentioning

confidence: 83%

“…The patient died 1 year later from intracranial extension of the tumor. In another case reported by Ni et al 4 . (case 4), the tumor showed extensive involvement with the paranasal sinus and lymph node metastasis, but the patient was lost to follow up.…”

Section: Discussionmentioning

confidence: 90%

“…The ceruminous gland in the external auditory canal and the Moll’s gland in the eyelid are also considered to be modified apocrine glands 10,11 . Neoplasms showing apocrine differentiation arise rarely in the ocular region, especially in the eyelid 1–8 . These apocrine neoplasms occasionally cause diagnostic problems both clinically and pathologically.…”

Section: Discussionmentioning

confidence: 99%

“…Among benign and malignant neoplasms that involve the eyelid or lacrimal caruncle region, adenocarcinomas exhibiting differentiation towards the apocrine sweat gland are some of the most infrequent, and the details of their clinicopathological features have been documented in only a few cases 1–8 . Although apocrine adenocarcinomas arising in the ocular region are generally considered to pursue a relatively indolent and protracted clinical course, 1,2 , 7,8 a few cases showing very aggressive biological behavior have also been reported 4,5 . The exact histogenesis of apocrine gland neoplasms in the ocular region is still unclear, but origin from the Moll’s gland, an apocrine gland located at the roots of the eyelashes, is considered most likely 1–8 …”

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confidence: 99%

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Apocrine adenocarcinoma of the eyelid with aggressive biological behavior: Report of a case

Shintaku

Tsuta

Yoshida

et al. 2002

Pathology International

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A case of apocrine adenocarcinoma of the eyelid that showed unusually aggressive biological behavior is reported. The patient was a 57-year-old man who complained of discomfort and excessive lacrimation of the left eye. A subcutaneous tumor measuring 2.5 cm was found at the medial canthus of the upper eyelid, and a plica-like subconjunctival spread was noted in the lacrimal caruncle. Invasion into the extraocular muscles and metastasis to the cervical lymph nodes and bone were already present at the time of initial presentation. Histopathologically, the tumor showed features of poorly differentiated adenocarcinoma, and polygonal tumor cells had large, hyperchromatic nuclei with prominent nucleoli and abundant eosinophilic cytoplasm. The formation of ductal structures was found occasionally. The differentiation of the tumor cells towards the apocrine gland was corroborated by immunohistochemistry using monoclonal antibodies GCDFP-15 and B72.3. The histogenesis and pathological differential diagnosis are discussed briefly, and the tumor was considered to have originated in the Moll's gland in the eyelid. This case emphasizes that apocrine adenocarcinomas of the ocular region have the potential for aggressive biological behavior, including distant metastasis.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Apocrine adenocarcinoma of the eyelid with aggressive biological behavior: Report of a case

Shintaku

Tsuta

Yoshida

et al. 2002

Pathology International

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“…The appearance of a lesion at the lid margin similar to a chalazion, is also a characteristic of another rare adnexal tumor-Moll gland adenocarcinoma. This tumor displays very aggressive biological behavior with extensive lymph node involvement and perineural invasion [9,10].…”

Section: Discussionmentioning

confidence: 99%

Primary cutaneous adenoid cystic carcinoma of the upper lid: a case report and literature review

Cavazza¹,

Laffi²,

Lodi³

et al. 2012

Int Ophthalmol

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To report on the diagnostic challenge of an adenoid cystic carcinoma arising from the eyelid. A 77-year-old male was referred to our center with a clinical diagnosis of upper eyelid chalazion for a lesion that had appeared 2 years before. A loss of cilia was observed over the cutaneous area of induration, but there was no reddening or ulceration. Incisional biopsy was performed and the specimen was submitted in formalin for histopathological examination. On light microscopy, the lesion was composed of basaloid epithelial and myoepithelial cells that were arranged in strands or nests and associated with cystic spaces that contained a deeply eosinophilic secretory substance and an Alcian blue-positive material, characteristic of adenoid cystic carcinoma. After histological diagnosis, tumor re-excision was performed to ensure adequacy of resection margins, as well as a sentinel lymph node procedure, resulting in complete excision of the malignant tumor. No recurrence was observed during the first 18 months after surgery. Adenoid cystic carcinoma is a rare and aggressive epithelial malignancy, which tends to grow slowly and should be considered in the differential diagnosis of eyelid tumors simulating chalazion.

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