Eyelid Tumors

Riis, Ronald C.; and, Connie M. Vitali; Simons, Kenneth B.

doi:10.1002/9780470376904.ch2

Cited by 7 publications

(19 citation statements)

References 124 publications

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“…It has been speculated in veterinary medicine that interstitial gamma radiation (Cobalt‐60, radon‐222, radium, cesium‐137 and gold‐198) may increase the risk of metastasis by promoting neoplastic cell movement into vascular and lymphatic vessels 7,20 and neoplastic seeding has been documented to occur in the physician literature 46,47 . Cryotherapy, while inexpensive, is associated with development of local edema and depigmentation of hair and skin, may lead to an unacceptable cosmetic outcome 12 . Radiofrequency hyperthermia carries the risk of ulcerative keratitis with scar formation and conjunctivitis 18 .…”

Section: Discussionmentioning

confidence: 99%

“…1,[5][6][7][8] Squamous cell carcinoma may involve the corneoconjunctiva, bulbar conjunctiva, third eyelid, and eyelids. 1,2,9,10 Biological behavior of SCC is reported to differ depending on location, 11,12 but is typically locally invasive and may result in blindness. 13 Metastasis to local lymph nodes, salivary glands, and lungs can occur.…”

Section: Introductionmentioning

confidence: 99%

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Photodynamic therapy for the treatment of periocular squamous cell carcinoma in horses: a pilot study

Giuliano

MacDonald

McCaw

et al. 2008

Veterinary Ophthalmology

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Objective Local photodynamic therapy (PDT) is a novel cancer therapy in veterinary ophthalmology. A prospective pilot study seeking to demonstrate proof of principle and safety for the treatment of equine periocular squamous cell carcinoma (PSCC) was therefore conducted. We hypothesized that surgical excision with adjunctive local PDT is an effective and safe treatment for equine PSCC. Procedures Nine horses (10 eyes) with PSCC were treated with surgical resection, local infiltration of resulting wound beds with 2-[1-hexyloxyethyl]-2-devinylpyropheophorbide-a (HPPH) and irradiation with 665-nm wavelength diode laser. Regular follow-up ophthalmic examinations were performed. Results Surgical resection and PDT yielded disease-free intervals of 25-68 months in our study horses as of January, 2008. These results were obtained following a single treatment in seven horses and two treatments in one horse. In one horse, carcinoma in situ developed 2.5 months after partial surgical excision and PDT, requiring local excision under standing sedation. Conclusions Preliminary results suggest that surgical resection and adjunctive local PDT is a safe and effective novel treatment for PSCC in horses. More research is needed before PDT for the treatment of equine PSCC can be adequately compared with other current modalities. Important to future investigations regarding PDT, tumor recurrence rate, length of hospitalization, number of treatment episodes required to effect tumor remission, and total treatment costs should be examined in a controlled manner. Our present results and experiences suggest that this treatment may be useful in the treatment of equine PSCC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Photodynamic therapy for the treatment of periocular squamous cell carcinoma in horses: a pilot study

Giuliano

MacDonald

McCaw

et al. 2008

Veterinary Ophthalmology

View full text Add to dashboard Cite

show abstract

“…SCC Radiation treatment for ophthalmic neoplasia, considered one of the most effective treatments for PSCC, requires special licensure and may be complicated by the development of keratitis and uveitis . Cryotherapy is an inexpensive treatment option but can lead to local edema and depigmentation of hair and skin . Radiofrequency hyperthermia may cause ulcerative keratitis with scar formation and conjunctivitis .…”

Section: Discussionmentioning

confidence: 99%

“…8,9,22,27,[55][56][57] Cryotherapy is an inexpensive treatment option but can lead to local edema and depigmentation of hair and skin. 13 Radiofrequency hyperthermia may cause ulcerative keratitis with scar formation and conjunctivitis. 19 Immunotherapy and intratumoral chemotherapy both require serial treatments over the course of several weeks and often result in disfiguring necrosis and suppuration at drug injection sites.…”

Section: Discussionmentioning

confidence: 99%