Tumours of the Larynx

Meyer-Breiting, E.; Burkhardt, A

doi:10.1007/978-3-642-71100-8

Cited by 50 publications

(31 citation statements)

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“…Many attempts have been made to establish a favor able prognostic significance of the local immune reaction which might be an expression of the immunologic de fenses against cancerous lesions [11,13,14,[23][24][25]. In relation to benign and malignant laryngeal hyperplastic lesions, no single view which attempts to prove a favor able influence of immunocompetent cells in the stromal tissue has been accepted [6.…”

Section: Discussionmentioning

confidence: 99%

Local Immune Response in Hyperplastic Lesions of the Larynx

Kambič

Gale²,

Fischinger³

1994

ORL

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A retrospective morphologic and immunohistochemical study of 25 benign and 5 malignant laryngeal hyperplastic lesions was performed concerning a local immune response which might be characteristic and of prognostic value for each particular group of these alterations, using Kambic’s classification, especially for precancerous and cancerous lesions. On paraffin and frozen sections, 7 monoclonal antibodies against various leukocytic antigens were used. CD43 and CD45RO T lymphocytes were the predominant cells in the infiltrates, and their frequency increased according to the degree of hyperplastic lesions. Next in frequency were CD4 cells, and a predominance of CD4 over CD8 cells was an obvious finding. The infiltration of CD68-, CD57-, and CD20-positive cells was generally weak. The intensity and composition of the local reaction in all cases of atypical hyperplasias was nearly identical, regardless of their subsequent behaviour. No apparent cytotoxic effects on the epithelial cells, either in precancerous or in cancerous lesions, were observed. Thus, the immunocompetent cells in the epithelial and stromal tissue are most likely not an effective defense in preventing hyperplastic lesions from becoming malignant. It seems that laryngeal hyperplastic lesions do not provoke an essential defense immune response, but the present local inflammatory reaction might be a constituent part of etiologically different inflammations which may lead to unfavorable lesions.

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Section: Discussionmentioning

confidence: 99%

Local Immune Response in Hyperplastic Lesions of the Larynx

Kambič

Gale²,

Fischinger³

1994

ORL

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“…There preferentially, cancer escapes the larynx [Kirchner, 1969;Olofsson and van Nostrand, 1973;Kirchner et al, 1974;Glanz, 1984;Kleinsasser. 1987;Meyer-Breiting andBurkhardt, 1988. Jahnke, 1995).…”

Section: Discussionmentioning

confidence: 99%

The Cricothyroid Space: Topography and Clinical Implications

Reidenbach

1996

Cells Tissues Organs

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The inferior border of the thyroid cartilage and the superior rim of the cricoid arch are connected by the cricothyroid membrane and partly covered by the cricothyroid muscles ventrally. This region has been termed the cricothyroid space (CS) and is important with regard to surgical procedures, the spread of laryngeal cancer and traumatic lesions of the larynx. The precise topographic relations of the CS were investigated in plastinated serial sections of 21 normal adult human specimens. The CS consists of a caudal and a cranial portion, which are different with regard to their cartilaginous framework and their relationship to intralaryngeal structures. The caudal portion is bordered by the cricoid cartilage and reveals a complete separation of extra- and intralaryngeal regions by the cricothyroid membrane. It provides an easy access to the subglottic airways. The cranial portion of the CS is mainly bordered by the thyroid cartilage. It is characterized by a gap lateral to the median cricothyroid ligament. This allows a connection of extra- and intralaryngeal adipose tissue. There, extralaryngeal extension of laryngeal cancer preferentially occurs. Traumatic subglottic ruptures of the larynx involve both the caudal and cranial portions of the CS, which often results in extensive scar tissue formation.

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“…Anatomists usually distinguish a supraglottic, a glottic, and a subglottic or infraglottic part (von Luschka, 1871;Gerlach, 1900;Testut, 1930;Pernkopf, 1952;von Lanz and Wachsmuth, 1955;Braus and Elze, 1956;Williams et al, 1989). In the clinical literature, this concept is widely accepted (Olofsson and van Nostrand, 1973;Tucker, 1974;Meyer-Breiting and Burkhardt, 1988;Jahnke, 1995). According to Jahnke's description (1995) (Fig.…”

Section: Introductionmentioning

confidence: 95%

Subglottic region: Normal topography and possible clinical implications

Reidenbach

1998

Clin. Anat.

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Tumours of the Larynx

Cited by 50 publications

References 0 publications

Local Immune Response in Hyperplastic Lesions of the Larynx

Local Immune Response in Hyperplastic Lesions of the Larynx

The Cricothyroid Space: Topography and Clinical Implications

Subglottic region: Normal topography and possible clinical implications

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