Subglottic region: Normal topography and possible clinical implications

Reidenbach, Martina Maria

doi:10.1002/(sici)1098-2353(1998)11:1<9::aid-ca2>3.0.co;2-r

Cited by 22 publications

(12 citation statements)

References 46 publications

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“…It is the superficial, thickened anteromedial part of the conus elasticus below the laryngeal mucosa (Dover et al, 1996) and arises from the cricoid cartilage with ventral densely arranged fibres, which make the ligament clearly distinguishable from the anterior overlying tissues and the looser arranged collagenous fibres toward the airway lumen. It stretches superiorly to the thyroid and arytenoid cartilages with the free superior margin being the cord (Reidenbach, 1998). The membrane may be pierced by small blood vessels, usually situated at its attachments to the thyroid and cricoid cartilages (Reidenbach, 1998).…”

Section: Cricothyroid Membranementioning

confidence: 99%

“…It stretches superiorly to the thyroid and arytenoid cartilages with the free superior margin being the cord (Reidenbach, 1998). The membrane may be pierced by small blood vessels, usually situated at its attachments to the thyroid and cricoid cartilages (Reidenbach, 1998). The size of the membrane varies in adults between 22-33 mm wide (beyond the cricothyroid muscles) and 9 -10 mm high (Kress and Balasubramaniam, 1982).…”

Section: Cricothyroid Membranementioning

confidence: 99%

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Cricothyroidotomy: A clinical anatomy review

et al. 2004

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The safe and successful performance of a cricothyroidotomy demands a working and yet specific knowledge of anatomy. An ignorance or misunderstanding of anatomy may result in failure or complications. The Educational Affairs Committee of the American Association of Clinical Anatomists has highlighted the importance of clinical anatomy for several invasive procedures. This review is building on their work and contribute further to the understanding of the anatomical framework, particularly the pitfalls and complications related to performing a cricothyroidotomy.

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Section: Cricothyroid Membranementioning

confidence: 99%

Section: Cricothyroid Membranementioning

confidence: 99%

Cricothyroidotomy: A clinical anatomy review

et al. 2004

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“…This research is hampered by the availability of primary human tissue originating from this difficult to sample site . Previous researchers have used animal models or human tissue from other airway locations, such as the nose or lung; however, this is unlikely to fully recapitulate the subglottic airway in humans, which is a distinct respiratory niche . We have previously reported the first description of primary human subglottic epithelial cell culture .…”

Section: Introductionmentioning

confidence: 99%

Establishment of an immortalized human subglottic epithelial cell line

et al. 2019

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Objective: Translational research into subglottic disease is restricted by the availability of primary human tissue originating from this subsite. Primary epithelial cells are also limited by their inability to survive beyond several divisions in culture outside of the body. Specific subglottic cell lines, useful for in vitro studies, have not yet been described. We therefore demonstrate what we believe to be the first immortalized subglottic epithelial cell line.Methods: Subglottic tissue was derived from a single adult patient's neoplasia-free human subglottic brushing specimen. Cells were immortalized using a lentiviral vector expressing simian virus 40 T antigen. Karyotyping was performed on the transformed cells using single nucleotide polymorphism array comparative genomic hybridization. Transformed cells were phenotypically characterized by light microscopy, immunohistochemistry, and electrophysiology studies.Results: The immortalized subglottic cell line (SG01) was able to divide successfully beyond 20 passages. Karyotyping demonstrated no significant genomic imbalance after immortalization. The cells demonstrated normal epithelial morphology and cytokeratin expression throughout. SG01 cells were also successfully cultured at air-liquid interface (ALI). At ALI cells demonstrated cilia, mucus production, and relevant ion channel expression.Conclusion: The novel SG01 subglottic epithelial cell line has been established. This cell line provides a unique resource for researchers to investigate subglottic diseases, such as subglottic stenosis.

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“…The problem with anatomical borders in staging laryngeal tumors is the considerable controversy about their margins [21,31], so that a major deficiency in classification is that it fails to define them adequately. No clinical guideline exists at present for defining the borders between the supraglottis, glottis and subglottis.…”

mentioning

confidence: 99%

“…In contrast, Laramore [23] stated that the subglottis starts 1 cm below the true cords and extends to the inferior border of the cricoid cartilage. More recently, Reidenbach [31] defined the superior border of the subglottic region by the transition of squamous stratified epithelium covering the vocal cords into the respiratory epithelium of the caudal airways.…”

mentioning

confidence: 99%

The pathology and management of subglottic cancer

Ferlito¹,

Rinaldo²

2000

European Archives of Oto-Rhino-Laryngology

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Because there is still considerable controversy concerning the anatomical boundaries separating the three regions of the larynx, cancer of the subglottis remains difficult to manage. We have reviewed the numerous differences in the anatomical definitions used in the literature and the consequent differences in reported findings on the incidence of subglottic cancer and its classification. We have also summarized the pathology of subglottic malignant neoplastic lesions, their presenting symptoms and tendency for spread, and the use of imaging methods in its diagnosis. Suitable forms of treatment are discussed, as are considerations on prognosis.

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Subglottic region: Normal topography and possible clinical implications

Cited by 22 publications

References 46 publications

Cricothyroidotomy: A clinical anatomy review

Cricothyroidotomy: A clinical anatomy review

Establishment of an immortalized human subglottic epithelial cell line

The pathology and management of subglottic cancer

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