Tumour targeted delivery of encapsulated dextran–doxorubicin conjugate using chitosan nanoparticles as carrier

Breast cancer: early diagnosis and effective treatment by drug delivery tracing

“…Encapsulated dextran-doxorubicin conjugate using chitosan nanoparticles as a carrier have been used in tumor targeted delivery. After 4 weekly injections, intravenously, in mice, the tumor volume of those treated with the encapsulated conjugate being only 60% of treated with the conjugate alone [29].…”

Approaches for Functional Modification or Cross‐Linking of Chitosan

“…For instance, chitosan-dextran sulfate micro-and nanoparticles were formed by the electrostatic interaction between the protonated amino groups of chitosan and the sulfate groups of dextran sulfate. These particles were used for controlled drug delivery applications since the synthesis route is simple and can be done in mild conditions [71,72]. The surface charge of this type of particles were tunable by varying the ratio of the two-polymer concentrations [73]; also, prepared particles have good stability and do not need any stabilization or additional cross-linking agent.…”

Conventional Chemotherapeutic Drug Nanoparticles for Cancer Treatment

“…Drug efficacy was potentiated by the activation of macrophages releasing cytotoxic factors such as NO, which resulted in increased tumor cell death [62]. Similarly, the use in a murine tumor model (implanted subcutaneously J774A.1 macrophages) of a dextrandoxorubicin conjugate incorporated into small chitosan nanospheres was reported to outperform the free conjugate, especially in relation to life expectancy [63].…”