Conventional Chemotherapeutic Drug Nanoparticles for Cancer Treatment

Serpe, Loredana

doi:10.1002/9783527610419.ntls0060

Cited by 12 publications

(13 citation statements)

References 130 publications

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“…31,32,39,45,48 To address the inherent limitations of the surface decoration approach and increase the transfection efficiency of calcium phosphate-based composite nanoparticles, recent work on the delivery of DNA, plasmid DNA (pDNA) and siRNA has focused on synthesizing smaller nanoparticle sizes and finding approaches to shield the genetic material within the nanoparticle. 11,[30][31][32]39,41,42,48,49 This has been a challenge because precipitation synthesis methods generally resulted in the accumulation of DNA on the surface of the nanoparticles. 30,31 While this was initially thought to prevent agglomeration by imparting a steric dispersing layer with negative charge on the particle surface, the DNA payload was not protected from enzymatic attack and agglomeration occurred in serum containing media, significantly reducing transfection efficiency.…”

Section: Oligonucleotide Deliverymentioning

confidence: 99%

“…To address the inherent limitations of the surface decoration approach and increase the transfection efficiency of calcium phosphate‐based composite nanoparticles, recent work on the delivery of DNA, plasmid DNA (pDNA) and siRNA has focused on synthesizing smaller nanoparticle sizes and finding approaches to shield the genetic material within the nanoparticle 11,30–32,39,41,42,48,49. This has been a challenge because precipitation synthesis methods generally resulted in the accumulation of DNA on the surface of the nanoparticles 30,31.…”

Section: Delivery Of Therapeuticsmentioning

confidence: 99%

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Calcium phosphate‐based composite nanoparticles in bioimaging and therapeutic delivery applications

Tabaković

Kester

Adair

2011

WIREs Nanomed Nanobiotechnol

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Bioimaging and therapeutic delivery applications are areas of biomedicine where nanoparticles have had significant impact, but the use of a nanomaterial in these applications can be limited by its physicochemical properties. Calcium phosphate-based composite nanoparticles are nontoxic and biodegradable, and are therefore considered attractive candidates for bioimaging and therapeutic drug delivery applications. Also, the pH-dependent solubility profiles of calcium phosphate materials make this class of nanoparticles especially useful for in vitro and in vivo delivery of dyes, oligonucleotides, and drugs. In this article, we discuss how calcium phosphate-based composite nanoparticles fulfill some of the requirements typically made for nanoparticles in biomedical applications. We also highlight recent studies in bioimaging and therapeutic delivery applications focusing on how these studies have addressed some of the challenges associated with using these nanoparticles in bioimaging and delivery of therapeutics.

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Section: Oligonucleotide Deliverymentioning

confidence: 99%

Section: Delivery Of Therapeuticsmentioning

confidence: 99%

Calcium phosphate‐based composite nanoparticles in bioimaging and therapeutic delivery applications

Tabaković

Kester

Adair

2011

WIREs Nanomed Nanobiotechnol

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“…This nonspecificity of the drug limits the therapeutic dose within cancer cells while providing excessive toxicities to normal cells, tissues, and organs and thereby causing several adverse effects. Besides precise tumor targeting and toxicity concerns, drug resistance remains a major obstacle for the treatment of advanced cancerous tumor [ 14 – 16 ]. “Cancer nanotechnology” is the novel emerging field which used nanocarriers like liposome, polymeric nanoparticles, dendrimers, quantum dots, polymersomes, carbon nanotubes, and so forth, for delivering drugs to the target site and thus holds tremendous potential to overcome several problems associated with the conventional therapies [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Carbon Nanotubes: An Emerging Drug Carrier for Targeting Cancer Cells

Rastogi

Yadav

Bhattacharya

et al. 2014

Journal of Drug Delivery

179

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During recent years carbon nanotubes (CNTs) have been attracted by many researchers as a drug delivery carrier. CNTs are the third allotropic form of carbon-fullerenes which were rolled into cylindrical tubes. To be integrated into the biological systems, CNTs can be chemically modified or functionalised with therapeutically active molecules by forming stable covalent bonds or supramolecular assemblies based on noncovalent interactions. Owing to their high carrying capacity, biocompatibility, and specificity to cells, various cancer cells have been explored with CNTs for evaluation of pharmacokinetic parameters, cell viability, cytotoxicty, and drug delivery in tumor cells. This review attempts to highlight all aspects of CNTs which render them as an effective anticancer drug carrier and imaging agent. Also the potential application of CNT in targeting metastatic cancer cells by entrapping biomolecules and anticancer drugs has been covered in this review.

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“…Since ultrasound increases the local temperature of the exposed tissues, hyperthermia can be used as an additional ultrasonic advantage (Figueiredo and Esenaliev, 2012) The (Serpe, 2006, Villela-Martinez et al, 2017.…”

Section: Free 5-fu Treated Group (Group Ii)mentioning

confidence: 99%

Amelioration of the therapeutic efficacy of 5-Flurouracil loaded chitosan nanoparticles in experimentally induced Hepatocellular Carcinoma

Mokhamer

Yehia

Ramadan

et al. 2019

Journal of Medical and Life Science

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Hepatocellular carcinoma (HCC) is the most common type of liver cancer. The most important risk factor for the development of HCC is cirrhosis regardless of etiology. 5-Fluorouracil (5-FU) is widely used in the treatment of cancer. Drug resistance remains a significant limitation to the clinical use of 5-FU. The present study aimed to evaluate the therapeutic efficacy of 5-FU loaded chitosan nanoparticles in experimentally induced HCC. To achieve our purpose, one hundred and five male Swiss Albino mice were divided randomly into two major groups: Group A: comprised 25 mice served as normal control, Group B: comprised 80 mice received a daily oral dose of 0.06% DAB (165 mg/kg body.wt.) for 30 days after which the water was replaced with 0.05% aqueous solution of Phenobarbital (PB). Five chosen mice randomly from groups A and B at the time intervals 15, 30, 45 and 60 days were sacrificed to follow up with the development of HCC by biochemical and histopathological examination. Animals of group B were divided into 3 groups Group I: included 20 mice served as an untreated group, group II: included 20 mice injected intraperitoneally with 5-FU only (40mg/kg body.wt) every 2 days for 16 days, group III: included 20 mice injected intraperitoneally with 5-FU Cs NPs. Each group was further divided into two subgroups 10 mice each, one subgroup treated with ultrasonic waves; meanwhile the other subgroup without ultrasonic waves exposure. At the end of the experiment, animals were sacrified, serum ALT, hepatic ALT, and hepatic MDA were estimated; HCC was histopathologically monitored in all studied groups. There was 276.5%, 145.7%and 438.5% increase in serum ALT, hepatic ALT and hepatic MDA levels respectively comparing to the corresponding control. Liver tumors that ultimately became neoplastic were produced after 45 days. US exposure triggered a significant decline in serum and hepatic ALT activity (P = 0.001) and in hepatic MDA (P = 0.009) within 5-FU loaded Cs NPs group. Moreover, tumor growth delay and more enhanced correction in hepatic architecture was obtained by a combination of US and 5-FU loaded Cs NPs therapy. Based on these results, we can conclude that the use of 5-FU loaded chitosan nanoparticles in combination with low-intensity ultrasound ameliorates the efficacy of 5-FU as anticancer therapy for HCC.

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Conventional Chemotherapeutic Drug Nanoparticles for Cancer Treatment

Abstract: The sections in this article are Introduction Cancer as Drug Delivery Target Nanoparticles as Anticancer Drug Delivery System Conventional Nanoparticles Sterically Stabilized Nanoparticles Actively Targetable Nanoparticles Routes of Drug Nanoparticles Administration … Show more

Cited by 12 publications

References 130 publications

Calcium phosphate‐based composite nanoparticles in bioimaging and therapeutic delivery applications

Calcium phosphate‐based composite nanoparticles in bioimaging and therapeutic delivery applications

Carbon Nanotubes: An Emerging Drug Carrier for Targeting Cancer Cells

Amelioration of the therapeutic efficacy of 5-Flurouracil loaded chitosan nanoparticles in experimentally induced Hepatocellular Carcinoma

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