Tumour scanning with indium-111 dihaematoporphyrin ether

Abstract

Photofrin II (dihaematoporphyrin ether/ester, DHE) was labelled with indium-111 and its biodistribution in tumour bearing mice compared with that of 111In chloride. The uptake and clearance of 111In labelled DHE differed markedly from that of indium-111 chloride in that the former was not taken up by the tissues as much as the latter. Scintillation scanning with a gamma-camera showed marked uptake of both 111In agents at the site of the tumour, but a much lower tissue background (excluding the abdominal organs) for the mice given 111In DHE. Tumour:muscle ratios of dissected tissues were 2-3 times higher in 111In DHE treated animals as compared to the uptake of 111In chloride. There was a distinct difference in the pattern of distribution of the two 111In preparations in the tissues. The major accumulation of 111In chloride was in the kidneys, whereas the highest uptake of 111In DHE was in the liver, the organ in which unlabelled porphyrins accumulate. Extraction and testing of materials from tumours of 111In DHE treated animals indicated that most of the tumour extractable 111In had remained associated with the porphyrin in vivo up to 4 days after injection. Images Figure 1

Nuclear imaging of liposomal drug delivery systems: A critical review of radiolabelling methods and applications in nanomedicine

“…(A) Uptake of ‘free’ radionuclides in various tissue/organs, including tumours. The actual chemical form administered is denoted in brackets (including 111 In [22], 99m Tc [23], 18 F [24], radio Ga [25,26], radio I [27], 64 Cu [28,29], 89 Zr [30], 52 Mn [31]); (B) Representative mouse SPECT or PET images (maximum intensity projections) showing the biodistribution of ‘free’ 99m Tc, 64 Cu (reprinted with permission from Peng et al [32], Copyright 2006 SNNMI), 89 Zr (reprinted with permission from Abou et al [30], Copyright 2011 Elsevier) and 52 Mn (reprinted with permission from Graves et al [31], Copyright 2015 ACS). (C) PET maximum intensity projection image of 64 CuCl 2 biodistribution in a prostate cancer patient (reprinted with permission from Piccardo et al [29], Copyright 2018 SNNMI).…”

Metal Complexes as Photo- and Radiosensitizers

“…Similarly, 111 In−TMPyP clearly delineated malignant melanoma tumors in the hamster. The clinically approved photosensitizers Photofrin and DHE were also labeled with 111 In and evaluated for tumor uptake in animal models …”

Synthese tumoraffiner Yb-169- und Y-90-Porphyrin-Komplexe und tierexperimentelle Untersuchung verschiedener Yb-169-Porphyrine

“…Im weiteren ist geplant, die Synthesen mit möglichst geringem Trägerzusatz durchzuführen. Andererseits ist es nach Angaben anderer Autoren sogar möglich, daß eine geringfügige und nichttoxische »Verunreinigung« durch freie Porphyrine die Me-Porphyrin-Bioverteilung nicht beeinträchtigt und sogar in gewissem Maße die Tumor/Untergrund-Verhältnisse verbessert (18). Tabelle (9).…”