Tumour necrosis factor-α induction by endotoxin-containing coal mine dusts in cultures of human macrophages and its effects on pneumocyte type II cells

Accumulation of indoor dust on electric heaters and light fixtures may produce a bad odor when switched on in the cold season and some people claim respiratory distress during such events. To investigate to what extent the residuals of heated indoor dust represent a health hazard, we measured the effect in cell cultures before and after heat treatment of the dust. The in vitro results imply that the residual dust will cause a lower proinflammatory response in the airways if suspended and inhaled compared with non-heated dust. This is partly explained by heat destruction of inflammatory components in the dust.

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Tumour necrosis factor-α induction by endotoxin-containing coal mine dusts in cultures of human macrophages and its effects on pneumocyte type II cells

Cited by 3 publications

References 27 publications

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Supernatants from quartz dust treated human macrophages stimulate cell proliferation of different human lung cells as well as collagen-synthesis of human diploid lung fibroblasts in vitro

Biological and Biochemical Characterisation of a “Proliferation Factor” from Quartz Dust-treated Human Macrophages

Heating of indoor dust causes reduction in its ability to stimulate release of IL-8 and TNFalpha in vitro compared to non-heated dust

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