Heating of indoor dust causes reduction in its ability to stimulate release of IL-8 and TNFalpha in vitro compared to non-heated dust

Abstract

Accumulation of indoor dust on electric heaters and light fixtures may produce a bad odor when switched on in the cold season and some people claim respiratory distress during such events. To investigate to what extent the residuals of heated indoor dust represent a health hazard, we measured the effect in cell cultures before and after heat treatment of the dust. The in vitro results imply that the residual dust will cause a lower proinflammatory response in the airways if suspended and inhaled compared with non-heated dust. This is partly explained by heat destruction of inflammatory components in the dust.

Induction of Proinflammatory Cytokines and C-Reactive Protein in Human Macrophage Cell Line U937 Exposed to Air Pollution Particulates

“…In vitro studies show increased levels of proinflammatory cytokines including TNFα, IL-1β, IL-6, and IL-8, which have been described in various cell types after exposure to PM (Mathiesen et al 2004; Monn et al 2003; Monn and Becker 1999; van Eeden et al 2001). Acute exposure to diesel exhaust also increased IL-8 production in human airways (Salvi et al 2000).…”

Asian dust storm particles induce a broad toxicological transcriptional program in human epidermal keratinocytes

“…Other environmental pollutants or organic contaminants may contribute to the increased IL-8 gene transcription in HEK by ADSPs. It has also been reported that exposure to fine dust particles (Particulate matter whose aerobic diameter equal or less than 2.5 m, PM 2.5 ) can increase the levels of IL-6 and IL-8 in various cell types, such as respiratory epithelial cells, after exposure to dust particles (Mathiesen et al, 2004;Monn and Becker, 1999;Monn et al, 2003;van Eeden et al, 2001). Therefore, we cannot exclude the possibility that fine dust particles (PM 2.5 ) in ADSPs are major contributors to ADSP-induced toxicity.…”

A Novel Approach for a Toxicity Prediction Model of Environmental Pollutants by Using a Quantitative Structure-Activity Relationship Method Based on Toxicogenomics

“…Inflammatory cytokines and chemokines play important roles in these inflammatory responses [17]. In particular, IL-8 is a well-known inflammatory cytokine involved in allergic inflammation [18], and its expression is upregulated by exposure of animals to diesel emissions or to treatment with DEP in vitro [19–23]. Although many reports suggest that diesel emission affects allergic responses, it is not clear what components of DEP are responsible for it.…”