Tumour necrosis factor-related apoptosis-inducing ligand and osteoprotegerin serum levels in psoriatic arthritis

Hofbauer, Lorenz C.; Schoppet, Michael; Christ, Michael; Teichmann, J.; Lange, U.

doi:10.1093/rheumatology/kel108

Cited by 56 publications

(70 citation statements)

References 22 publications

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“…These findings could be of relevant importance in determining the correct number of working OBs which are needed to build new bone. Moreover, in pathological conditions, in which the overexpression of TRAIL has been demonstrated [36][37][38][39][40][41], our data suggest that TRAIL could contribute to the impairment of OB differentiation by targeting the apoptosis of OB precursors.…”

Section: Discussionmentioning

confidence: 65%

Osteoblasts Display Different Responsiveness to TRAIL-Induced Apoptosis During Their Differentiation Process

Brunetti

Oranger

Carbone

et al. 2013

Cell Biochem Biophys

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Apoptosis can occur throughout the life span of osteoblasts (OBs), beginning from the early stages of differentiation and continuing throughout all stages of their working life. Here, we investigated the effects of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) on normal human OBs showing for the first time that the expression of TRAIL receptors is modulated during OB differentiation. In particular, the TRAIL receptor ratio was in favor of the deaths because of the low expression of DcR2 in undifferentiated OBs, differently it was shifted toward the decoys in differentiated ones. Undifferentiated OBs treated with TRAIL showed reduced cell viability, whereas differentiated OBs displayed TRAIL resistance. The OB sensitiveness to TRAIL was due to the up-regulation of DR5 and the down-regulation of DcR2. The main death receptor involved in TRAIL-reduced OB viability was DR5 as demonstrated by the rescue of cell viability observed in the presence of anti-DR5 neutralizing antibody. Besides the ratio of TRAIL receptors, the sensitivity of undifferentiated OBs to TRAIL-cytotoxic effect was also associated with low mRNA levels of intracellular anti-apoptotic proteins, such as cFLIP, the activation of caspase-8 and -3, as well as the DNA fragmentation. This study suggests that apoptotic effect exerted by TRAIL/ TRAIL-receptor system on normal human OB is strictly dependent upon cell differentiation status.

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Section: Discussionmentioning

confidence: 65%

Osteoblasts Display Different Responsiveness to TRAIL-Induced Apoptosis During Their Differentiation Process

Brunetti

Oranger

Carbone

et al. 2013

Cell Biochem Biophys

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“…PsA itself is characterised by synovitis, enthesitis, dactylitis and spondylitis usually accompanied with skin and very often nail psoriasis [8]. Apart from chronic inflammation, medications such as methotrexate or steroids, and sometimes prolonged immobilization due to joint pain have been recognized as possible risk factors that contribute to bone loss in those patients [9].In spite of that in PsA there is a lot of controversy about it, as the results of bone status in these patients are still conflicting [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Osteoporosis in psoriatic arthritis: Is there any?

Grazio

Cvijetić

Vlak

et al. 2011

Wien Klin Wochenschr

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Aims: Although considered as a feature of inflammatory rheumatic diseases, there is a lot of controversy around low bone mass in patients with psoriatic arthritis. The aim of this cross-sectional study was to analyze bone mineral density in patients with psoriatic arthritis, as well as to investigate its possible association with some measures of disease activity and functional capacity. Subjects and Methods:Sixty-nine patients with established psoriatic arthritis (mean age 56.20±12.23 years) and who has not been treated with specific antiosteoporotic drugs were recruited from the outpatient clinic database. Bone mineral density was measured by dual-energy X-ray absorptiometry at the lumbar spine and at the left hip. Disease activity measures included: duration of morning stiffness, tender and swollen joint count, patient's and physician's global assessment, presence of dactylitis and enthesitis, ESR, CRP and Disease Activity Score 28. Health Assessment Questionnaire was used to assess functional status.Results: According to WHO definition, spinal osteoporosis was found in 7.2% of patients, total hip osteoporosis in 1.4% of patients and femoral neck osteoporosis in 2.9% of patients. There was no significant association of any of the measures of disease activity with BMD at any site. Higher HAQ scores were associated with lower total hip BMD.Conclusions: In our sample of patients with psoriatic arthritis we did not find increased prevalence of osteoporosis. There was no association of BMD with indices of disease activity, while negative correlation was found between HAQ and total hip BMD.

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“…No significant difference was detected between the pSS group and healthy controls (p>0.01). studies on patients with SLE (11,12) and psoriatic arthritis (26), it was found that sTRAIL levels were higher than in healthy controls but there was no correlation between disease activity and sTRAIL levels. When we assessed the relationships between disease activity and sTRAIL levels, we found no significant correlation between sTRAIL level and the tender and swollen joint count, ESR, CRP and DAS28 score.…”

Section: Resultsmentioning

confidence: 97%

The Relationship between Plasma sTRAIL Level and Disease Activity in Rheumatoid Arthritis

Erbasan¹,

Yazısız²,

Kahraman³

et al. 2017

Akd Med J

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Tumour necrosis factor-related apoptosis-inducing ligand and osteoprotegerin serum levels in psoriatic arthritis

Abstract: In summary, BMD is decreased in one-third of patients with PsA, and predominantly men with PsA suffer from osteoporosis. While TRAIL serum levels are increased in PsA and correlated with CRP levels, neither TRAIL nor OPG serum levels are correlated with BMD or markers of bone metabolism.

Cited by 56 publications

References 22 publications

Osteoblasts Display Different Responsiveness to TRAIL-Induced Apoptosis During Their Differentiation Process

Osteoblasts Display Different Responsiveness to TRAIL-Induced Apoptosis During Their Differentiation Process

Osteoporosis in psoriatic arthritis: Is there any?

The Relationship between Plasma sTRAIL Level and Disease Activity in Rheumatoid Arthritis

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