Tumour necrosis factor gene polymorphisms and migraine: A systematic review and meta-analysis

Abstract

Background Data on the association between TNF-alpha and TNF-beta gene polymorphisms and migraine are conflicting. Methods We performed a systematic review and meta-analysis of studies published until January 2011. We used data from published papers and as provided after contact with the authors. We calculated study specific odds ratios (OR) and 95% confidence intervals (CI) assuming additive, dominant, and recessive genetic models as well as pooled effect estimates. Results Among the ten studies identified the best evidence is available for the TNF-alpha -308G>A and TNF-beta 252A>G polymorphisms indicating no overall association with migraine. Subgroup analyses suggested that the A allele of the TNF-alpha -308G>A variant more than doubles the risk for migraine among populations with a heterogeneous ethnic background, which was driven by associations for MO (additive model: pooled OR=2.87; 95% CI 1.86–4.43). Further, the risk for MA was increased among Asian populations (additive model: pooled OR=1.71; 95% CI 1.07–2.71). Both observed effects were stronger among females than males. Conclusions Our results indicate no overall association between TNF-alpha and TNF-beta gene variants. However, associations differed among specific populations. Our findings need to be treated with caution and further targeted research is warranted to evaluate population-specific effects including population stratification.

Effects of Tumor Necrosis Factor-β (TNF-β) 252A>G Polymorphism on the Development of Migraine: A Meta-Analysis

“…Neither did the investigators find effect modification of MA or MO in women or men in the meta-analysis, where ethnicity-specific analysis was not carried out [35]. Although our meta-analysis including one more new dataset also suggested no significant associations in either women or men with migraine or MO, an OR that suggested statistically increased risk of migraine was observed in Asian populations.…”

Biomarkers Associated With Migraine and Their Potential Role in Migraine Management

“…Migraine Type/Features Action in Relation to Migraine Dopamine type 2 (D2) receptor 23 Migraine with and without aura 23,91 • Vasoconstriction • Reduces trigeminal nerve activation • Inhibits release of vasoactive neuropeptide • Interrupts pain transmission centrally Glutathione S-transferase 92 Migraine without aura 92 • Increases susceptibility to environmental xenobioticinduced migraine attacks in GSTM1 genotype Dopamine type 4 (D4) receptor 93 Migraine without aura 93 • A potential genetic association exists between dopamine D4 receptor gene and migraine without aura Tumor necrosis factor-a 94 Migraine without aura 95 • Proinflammatory cytokine Methyltetrahydrofolate reductase (MTHFR) C677T allele 96 Migraine with aura 96 • MTHFR C677T polymorphism may increase homocysteine levels associated with migraine with aura Dopamine b-hydroxylase gene 97 Migraine with aura 97 • An intracellular enzyme catalyzing the conversion of dopamine to noradrenaline; imbalance may increase susceptibility to migraine Angiotensin-converting enzyme allele 98 Migraine with and without aura 90,99,100 • Involved in vasoconstriction and vascular remodeling…”

Association between the C804A polymorphism in the TGF-β gene and the risk of myocardial infarction: a meta-analysis

“…A large number of meta-analyses have been conducted to investigate the association between the TNF-β gene and various diseases (Schürks et al, 2011;Tiancha et al, 2011;Yang et al, 2012;Zhou et al, 2012;Xu et al, 2013). Our study is the first meta-analysis to describe the association between the TNF-β C804A polymorphism and MI risk.…”