Association between the C804A polymorphism in the TGF-β gene and the risk of myocardial infarction: a meta-analysis

Abstract

ABSTRACT. Tumor necrosis factor-b (TNF-b) is an important mediator of inflammation and may play a role in the pathogenesis of myocardial infarction (MI). While several published studies have investigated the association between the C804A polymorphism in the TNF-β gene and MI risk, their results are controversial and ambiguous. In this study, we evaluated the contribution of the TNF-β C804A polymorphism to MI risk. A literature search was conducted in the PubMed, Embase, Web of Science, Cochrane Library, and Google Scholar databases to identify eligible studies published before November 1, 2013. We performed a meta-analysis of 9 case-control studies, which included a total of 19,404 MI patients and 13,684 healthy controls. Overall analysis suggested that the TNF-β C804A polymorphism was associated with a significantly increased risk of MI. Stratified analysis based on ethnicity revealed a significant association in Asian populations, but not in Caucasian populations. In conclusion, this meta-analysis revealed that the TNF-β C804A polymorphism may be associated with an increased risk of MI only in Asian populations. However, additional studies should be TGF-β C804A polymorphism and myocardial infarction risk conducted to further confirm the association between TNF-β C804A and MI risk.

Association between TNF-α rs1800629 polymorphism and the risk of myocardial infarction: A meta-analysis

“…Many studies have previously investigated the association between TNF-α G-308A polymorphism and MI risk, but have yielded inconsistent results. Meta-analysis is a useful method to combine various single studies to obtain a larger sample size (Bax et al, 2007;Zeng et al, 2015a), and has been widely used in genetic association studies (Leng et al, 2013;Mao et al, 2013;Yan et al, 2014;Suo et al, 2015;Zeng et al, 2015b). In the present study, we performed a metaanalysis to evaluate the association between TNF-α G-308A polymorphism and MI risk.…”

“…Potential publication bias was assessed by visual inspection of funnel plots and the Egger test (Mao et al, 2013;Zeng et al, 2015b). Five genetic models were used for overall and subgroup analyses (Suo et al, 2015;Zeng et al, 2015b): A vs G, AA vs GG, AG vs GG, (AG+AA) vs GG, and AA vs (AG+GG).…”

“…Diabetes mellitus (Sattar, 2013), obesity (Yatsuya et al, 2010), psychological factors (Edmondson et al, 2013), and smoking (Meyers et al, 2009) are all associated with increased risk of MI. These factors act in concert with the multiple inherited genetic variants (Olivieri et al, 2006;Schunkert et al, 2010;Suo et al, 2015) that may lead to onset of MI.…”