Tumour necrosis factor-alpha levels in aqueous humour and serum from patients with uveitis: the involvement of HLA-B27

Abstract

The concentration of TNF-alpha in aqueous humour in patients who are HLA-B27 positive is significantly greater than in those who are B27 negative. No significant differences in the concentrations of TNF-alpha in serum or aqueous humour in patients with or without rheumatic diseases were detected. TNF-alpha is a cytokine that may participate actively in the pathogenesis of clinical uveitis.

Cytokines and Chemokines in Uveitis - Is there a Correlation with Clinical Phenotype?

“…86 Corresponding serum and aqueous humor elevations of TNF-α have also been detected in patients with ankylosing spondylitis and anterior uveitis. 167 A greater elevation of IL-6 in aqueous humor as compared to serum has been reported. 113 Serum cytokine assays have revealed ankylosing spondylitis to be associated with increased TNF-α, 168 as well as IL-6 168,169 but not IL-1β or IFN-γ.…”

Association between Helicobacter pylori infection and Posner–Schlossman syndrome

“…30 The activated macrophage by H. pylori also produce proinflammatory cytokines; IL-1, IL-6, IL-8, IL-10, IL-12, TNF-a, and IFN-g. 20 Most of these cytokines are also increased in the aqueous humour of the patients with idiopathic acute anterior uveitis, and TNF-a may participate actively in the pathogenesis of clinical uveitis. 31 H. pylori and its antibodies circulate the blood stream, and eventually enter the anterior chamber of both eyes through blood-aqueous humour barrier. However, PSS usually occurs repeatedly in unilateral eye, but not in bilateral eyes.…”

Associação do sistema de histocompatibilidade humano com doenças oftalmológicas

“…Os mecanismos imunológicos de tolerância ainda não foram completamente esclarecidos, mas supõe-se que, através do reconhecimento do epítopo citado, ocorra geração de células T supressoras e alterações na regulação de algumas citocinas (29) . A positividade do antígeno HLA-B27 também parece implicar em maiores níveis de TNF-α (citocina que participa ativamente na patogênese da uveíte) no humor aquoso de pacientes com uveíte ativa (30) . Novas drogas inibidoras do TNF-α têm sido propostas para o tratamento da uveíte associada ao antígeno HLA-B27 (31) .…”