Associação do sistema de histocompatibilidade humano com doenças oftalmológicas

Alves, Crésio de Aragão Dantas; Meyer, Isadora; Toralles, Maria Betânia Pereira; Marback, Roberto Lorens

doi:10.1590/s0004-27492006000200026

Cited by 8 publications

(13 citation statements)

References 48 publications

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“…1,2 The former typifies the histocompatibility antigens expressed in cellular surfaces. This method employs the cellular microlymphocytotoxicity mediated by antibodies and complement-dependent (serologic method of Terasaki) or by mixed lymphocyte culture, in which cells with known phenotypes are used to define HLA specificities.…”

Section: Methods To Detect Hla Antigens and Allelesmentioning

confidence: 99%

“…This method employs the cellular microlymphocytotoxicity mediated by antibodies and complement-dependent (serologic method of Terasaki) or by mixed lymphocyte culture, in which cells with known phenotypes are used to define HLA specificities. 1,2 In the molecular method, HLA allele typing is performed by means of DNA amplification through the polymerase chain reaction (PCR), using either the method called sequence specific primers (SSP) or sequence specific oligonucleotide probes (SSOP).…”

Section: Methods To Detect Hla Antigens and Allelesmentioning

confidence: 99%

“…10 The nomenclature of Class II HLA alleles of loci -DQ and -DP also expresses the type of heterodimer chain of its molecules (α ou β), which are named with letters "A" or "B", respectively (e.g., HLA-DQB1*1101, -DQA*0102). 1 In HLA-DR molecules, polymorphism occurs only in domain β1 of β chains, since the α is not polymorphic. Therefore, in HLA-DR, only the letter "B" is added.…”

Section: 2mentioning

confidence: 99%

“…1 In humans, MHC is located in the short arm of chromosome 6 and it is called HLA (human leukocyte antigens) system. [1][2][3] The genes in the HLA system have been classified into three regions: class I, II and III.…”

Section: Introductionmentioning

confidence: 99%

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Antígenos de histocompatibilidade humanos e dermatologia: da pesquisa para a prática clínica

Alves

Vieira

Meyer

et al. 2006

An. Bras. Dermatol.

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Abstract:The participation of the human histocompatibility system (HLA: human leukocyte antigens) in the pathogenesis of autoimmune diseases is well known. Situated on the short arm of chromosome 6, the HLA system is very polymorphic and has the capacity to confer susceptibility or resistance to different diseases. In Dermatology, this system has an important participation in the pathogenesis and natural course of various diseases. The strength and type of association differ with conditions and sometimes with the ethnic-racial group studied. The discovery of molecular methods to typify HLA alleles and recent updates in its nomenclature has contributed to a better understanding of this system. Unfortunately, this information has not been adequately transmitted in the literature, hindering identification of the association of the HLA with skin diseases. In this review, some aspects of the HLA system are discussed, such as methods of detection, nomenclature and association with vitiligo, pemphigus, psoriasis, lupus erythematosus, scabies, cutaneous leishmaniasis, leprosy, paracoccidiodomycosis and atopic dermatitis.

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Section: Methods To Detect Hla Antigens and Allelesmentioning

confidence: 99%

Section: Methods To Detect Hla Antigens and Allelesmentioning

confidence: 99%

Section: 2mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Antígenos de histocompatibilidade humanos e dermatologia: da pesquisa para a prática clínica

Alves

Vieira

Meyer

et al. 2006

An. Bras. Dermatol.

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“…Essas moléculas são responsáveis pela apresentação de antígenos aos linfócitos, células responsáveis pelo desencadeamento da resposta imune (1) . Os genes do sistema HLA apresentam diversos polimorfismos, sendo que alguns deles (3) estão associados a maior susceptibilidade a várias doenças, inclusive oftalmológicas. A tabela 1 apresenta uveítes associadas com polimorfismos de determinadas moléculas HLA (3)(4)(5)(6) .…”

Section: Resumo Introduçãounclassified

Imunogenética das uveítes

Cordeiro¹,

Moreira²,

Dutra³

et al. 2008

Arq. Bras. Oftalmol.

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Increased Prevalence of Autoimmunity in Patients With White Spot Syndromes and Their Family Members

Pearlman

Golchet²,

Feldmann³

et al. 2009

Arch Ophthalmol

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To determine whether there is an increased prevalence of systemic autoimmune diseases in both patients with white spot syndromes (WSS) and their family members.Methods: Patients with WSS at participating institutions were asked to complete a questionnaire reporting their own medical histories as well as any autoimmune diseases among their first-and second-degree relatives.Results: As of January 1, 2008, 114 questionnaires had been collected, providing medical histories of 114 patients with WSS and 1098 family members. The number of patients with WSS with self-reported systemic autoimmune diseases was 26 (23%). Of 1098 relatives, 106 (10%) had at least 1 autoimmune disease. Systemic autoimmunity was more prevalent in female relatives (13%) as compared with male relatives (6%). In addition, the prevalence of autoimmunity was significantly higher among first-degree relatives (13%) than second-degree relatives (8%). Patients who themselves had systemic autoimmune diseases showed a greater prevalence of systemic autoimmunity among their families as compared with the families of patients without systemic autoimmune diseases.Conclusions: Our data indicate that there is an increased prevalence of systemic autoimmunity in both patients with WSS and their first-and second-degree relatives. This suggests that WSS occur in families with inherited immune dysregulation that predisposes to autoimmunity.

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Associação do sistema de histocompatibilidade humano com doenças oftalmológicas

Cited by 8 publications

References 48 publications

Antígenos de histocompatibilidade humanos e dermatologia: da pesquisa para a prática clínica

Antígenos de histocompatibilidade humanos e dermatologia: da pesquisa para a prática clínica

Imunogenética das uveítes

Increased Prevalence of Autoimmunity in Patients With White Spot Syndromes and Their Family Members

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