Tumour cell invasion into blood vessels is significantly related to breast cancer subtypes and decreased survival

Tumor-associated macrophages (TAM) resemble M2 macrophages, promote tumor invasion and show strong expression of CD163 in breast cancer. We here investigated the association between CD163-positive macrophages and vascular invasion, molecular subgroups, mode of detection, and patient outcome. We performed a population-based, retrospective study of invasive breast cancer from the Norwegian Breast Cancer Screening Programme in Vestfold County (2004-2009), including 200 screen-detected and 82 interval cancers. Immunohistochemically CD163-positive macrophages were counted in the most active areas (hotspots) and dichotomized as high (upper quartile) and low counts. Lymphatic vessel involvement (LVI) and blood vessel invasion (BVI) were recorded separately based on immunohistochemical staining (D2-40 and CD31 antibodies). High levels of CD163-positive macrophages were associated with BVI and lymphatic involvement as well as interval cancer detection when compared to screening-detected tumors. In addition, the presence of high CD163+ TAM levels was more often observed in HER2-positive, basal-like and Triple-negative breast cancers and was associated with several features of aggressive tumors. In survival analyses, cases with combined high CD163 counts and BVI showed a significantly reduced recurrence-free survival (RFS) and disease-specific survival (DSS) (P < .001 for both) compared with all other cases. The presence of CD163-positive, tumor-associated macrophages is strongly related to aggressive features of breast cancer such as vessel invasion, detection between screening intervals, non-luminal molecular subgroups and reduced survival.

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“…have been described previously (3,16), using whole sections. VI was most often found in peritumoral areas.…”

Section: Immunohistochemistry and Evaluation Of Staining For LVI (D2-mentioning

confidence: 99%

“…Vascular invasion (VI) in breast cancer is associated with increased risk of recurrence, metastases and death of the disease (1,2). In a recent study we demonstrated that BVI was strongly related to a basal-like phenotype, interval cancer presentation and poor prognosis (3).…”

Section: Introductionmentioning

confidence: 99%

Tumor-associated macrophages are strongly related to vascular invasion, non-luminal subtypes, and interval breast cancer

et al. 2017

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“…However, using a nomogram in clinical practice might be time-consuming and at risk of difficult interpretation. Klingen TA et al reported that LVI was associated with HER2-positive and several features of aggressive breast cancer such as larger tumor size, higher histological grade, lymph node positive tumors and higher Ki67 expression [7]. Conventional MRI provides morphologic characteristics of the lesions with high spatial resolution, such as the margin morphology, or the internal architecture of the tumors [8].…”

Section: Introductionmentioning

confidence: 99%

Development of a risk-stratification scoring system for predicting lymphovascular invasion in breast cancer

Nijiati¹,

Aihaiti²,

Huojia³

et al. 2020

BMC Cancer

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“…As mentioned earlier, blood vessels can also serve as an escape route for cancer cells. Indeed, blood vessel invasion in primary tumors can serve as a prognostic indicator for many different cancers [25,40,41]. Recently, intravital imaging of experimental models of cancer has provided insight into the mechanism of intravasation of cancer cells.…”

Section: Lymphangiogenesis Facilitates Metastasis To Lymph Nodesmentioning

confidence: 99%

“…Thus, the universe of molecules and networks -predicted and unexpected -involved in normal and abnormal lymphangiogenesis and lymphatic function has greatly expanded raising questions of their role, interactions, and feedback loops in a variety of diseases including cancer. Related controversy persists around the relative importance and even the nature of lymphatic vs. blood vessel invasion; interendothelial vs. intra/transendothelial passage of tumor cells; lymphogenous vs. hematogenous spread within and from the primary tumor and metastatic sites, particularly regional lymph nodes and central lymphatics [21][22][23][24][25].…”

mentioning

confidence: 99%

Lymphangiogenesis, lymphatic systemomics, and cancer: context, advances and unanswered questions

Dellinger

Witte

2018

Clin Exp Metastasis

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Ever since it was discovered that endothelial cells line lymphatic vessels, investigators have been working on unraveling the mechanisms that control the growth of this distinctive endothelium and its role in normal physiology and human disease. Recent technological advances have ushered in a new era of "omics" research on the lymphatic system. Research on the genome, transcriptome, proteome, and metabolome of lymphatics has increased our understanding of the biology of the lymphatic vasculature. Here, we introduce the context-lymphatic "systemomics," then briefly review some of the latest advances in research on tumor-associated lymphatic vessels highlighting several "omic" studies that have shed light on mechanisms controlling the growth and function of tumor-associated lymphatic vessels. We conclude by returning, with unanswered questions, to the larger context of cancer and the lymphatic system as a vasculature, circulation, route of entry and transport, and control center of the immune network.

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Tumour cell invasion into blood vessels is significantly related to breast cancer subtypes and decreased survival

Abstract: Our findings indicate that BVI by tumour cells is strongly associated with aggressive tumour features including a basal-like phenotype, and BVI was an independent prognostic factor in contrast to what was found for LVI.

Cited by 20 publications

References 29 publications

Tumor-associated macrophages are strongly related to vascular invasion, non-luminal subtypes, and interval breast cancer

Tumor-associated macrophages are strongly related to vascular invasion, non-luminal subtypes, and interval breast cancer

Development of a risk-stratification scoring system for predicting lymphovascular invasion in breast cancer

Lymphangiogenesis, lymphatic systemomics, and cancer: context, advances and unanswered questions

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