Tumour budding, uPA and PAI‐1 are associated with aggressive behaviour in colon cancer

Abstract

The results of our study show that tumour budding and the plasmin/plasminogen system are related. PAI-1 was independently predictive for the occurrence of distant metastasis.

Multifunctional roles of urokinase plasminogen activator (uPA) in cancer stemness and chemoresistance of pancreatic cancer

“…Because increased expression of uPA is associated with higher “aggressiveness” for multiple tumor types, including pancreatic adenocarcinoma (Ceccarelli et al. , 2010; Markl et al. , 2010; Bekes et al.…”

Urokinase-Type Plasminogen Activator Deficiency Promotes Neoplasmatogenesis in the Colon of Mice

“…At 7 months past DSS treatments, despite exhaustive histologic sectioning, we found no invasive carcinoma lesions neither in the flat dysplastic lesions nor in the stalk or the submucosa at the base of the polyps. Additional studies on uPA −/− mice using more aggressive DSS treatment protocols or protocols combining DSS with chemical carcinogens may be necessary to reveal whether adenoma lesions are able to evolve to carcinoma or if neoplastic cell invasion is reduced (or even halted) due to uPA deficiency, as other reports suggest [15], [18], [24], [25], [36], [48].…”

ARNTL2 and SERPINE1: potential biomarkers for tumor aggressiveness in colorectal cancer

“…Cellmatrix interactions play a key role during carcinogenesis, and balance of cell-matrix communication is maintained by physical contact and by transmembrane integrin receptors, with bi-directional signalling between the extracellular and intracellular environments (Madsen and Sidenius 2008). Plasmin is a protease that is involved in this process (Märkl et al 2010). The balance between plasminogen activators and inhibitors regulates the proteolytic cascade that is responsible for plasmin formation, and the role of plasminogen activators in neoplastic growth is well established both by in vitro and in vivo studies (Sier et al 1994).…”