ARNTL2 and SERPINE1: potential biomarkers for tumor aggressiveness in colorectal cancer

Mazzoccoli, Gianluigi; Pazienza, Valerio; Panza, Anna; Valvano, Maria Rosa; Benegiamo, Giorgia; Vinciguerra, Manlio; Andriulli, Angelo; Piepoli, Ada

doi:10.1007/s00432-011-1126-6

Cited by 113 publications

(92 citation statements)

References 81 publications

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“…Many previous studies have detected its aberrant expression in cancers. For instance, SERPINE1 was found to be high‐expressed in colorectal cancer and related to tumour invasiveness and aggressiveness 15. Overexpression of SERPINE1 has also been found in many other cancers including melanoma,16 oesophageal cancer17 and bladder cancer 18.…”

Section: Introductionmentioning

confidence: 99%

Retracted: MircoRNA‐1275 promotes proliferation, invasion and migration of glioma cells via SERPINE1

Wang

Wen

et al. 2018

J Cellular Molecular Medi

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This study was designed to explore the relationship between miR‐1275 and SERPINE1 and its effects on glioma cell proliferation, migration, invasion and apoptosis. Differentially expressed miRNAs and mRNAs in glioma tissues were screened out by bioinformatic analysis. Dual‐luciferase reporter gene assay was used to validate the targeted relationship between miR‐1275 and SERPINE1. qRT‐PCR was used to detect the expression of miR‐1275 and SERPINE1 in glioma tissues. The expressions of SERPINE1 and p53 pathway‐related proteins in glioma cells were detected by western blot. Glioma cell proliferation, apoptosis, migration and invasion were respectively detected by CCK‐8 assay, flow cytometry, wound healing assay and transwell assay. Tumour xenograft model was developed to study the influence of miR‐1275 and SERPINE1 on glioma growth in vivo. The results of microarray analysis, qRT‐PCR and western blot showed that miR‐1275 was low‐expressed while SERPINE1 was high‐expressed in glioma. Dual‐luciferase assay showed that miR‐1275 could bind to SERPINE1. Overexpression of miR‐1275 could promote the p53 pathway‐related proteins’ expression. Highly expressed miR‐1275 could repress the migration, proliferation and invasion of glioma cells while highly expressed SERPINE1 had inverse effects. Tumour xenograft showed that up‐regulated miR‐1275 or down‐regulated SERPINE1 could repress glioma growth in vivo. Up‐regulation of miR‐1275 activated p53 signalling pathway via regulating SERPINE1 and therefore suppressed glioma cell proliferation, invasion and migration, whereas promoted cell apoptosis.

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Section: Introductionmentioning

confidence: 99%

Retracted: MircoRNA‐1275 promotes proliferation, invasion and migration of glioma cells via SERPINE1

Wang

Wen

et al. 2018

J Cellular Molecular Medi

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“…Additionally, significant increases were observed in the pro-angiogenic factor IL-8 (2.0-fold) and ECM remodeling protein uPA (12.7-fold); however, no changes in other pro-angiogenic factors, such as vascular endothelial growth factor, placenta growth factor, basic fibroblast growth factor, platelet-derived growth factor, and matrix metalloproteinase-8 and 9 were detected. Unexpected increases in the anti-angiogenic factors, serpin E1 (2.4-fold), endostatin (2.6-fold) and Timp-1 (2.8-fold) were found in the CM of TS-fibroblast co-cultures, and warrant further investigation regarding their role in migration and invasion [28][29][30].…”

Section: Changes In Expression Of Ecm and Plasma Membrane Signaling Fmentioning

confidence: 99%

Co-culture of 3D tumor spheroids with fibroblasts as a model for epithelial–mesenchymal transition in vitro

Kim

Lee

Kuh

2015

Experimental Cell Research

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“…These were ARNTL2, BCL3, IRF5, PLAGL2, and VAV1. ARNTL2, PLAGL2, and VAV1 have so far been described in relation to malignancies (21,23,34) and diabetes (16).…”

Section: Global Effect Of Il-10mentioning

confidence: 99%

Global Effect of Interleukin-10 on the Transcriptional Profile Induced by Neisseria meningitidis in Human Monocytes

et al. 2012

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ARNTL2 and SERPINE1: potential biomarkers for tumor aggressiveness in colorectal cancer

Abstract: ARNTL2 and SERPINE1 expression is increased in colorectal cancer and in a highly proliferative colon cancer cell line and is related to tumor invasiveness and aggressiveness.

Cited by 113 publications

References 81 publications

Retracted: MircoRNA‐1275 promotes proliferation, invasion and migration of glioma cells via SERPINE1

Retracted: MircoRNA‐1275 promotes proliferation, invasion and migration of glioma cells via SERPINE1

Co-culture of 3D tumor spheroids with fibroblasts as a model for epithelial–mesenchymal transition in vitro

Global Effect of Interleukin-10 on the Transcriptional Profile Induced by Neisseria meningitidis in Human Monocytes

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