Tumour budding evaluated in biopsy specimens is a useful predictor of prognosis in patients with cN0 early stage oral squamous cell carcinoma

Seki, Masaaki; Sano, Takaaki; Yokoo, Satoshi; Oyama, Tetsunari

doi:10.1111/his.13144

Cited by 50 publications

(89 citation statements)

References 23 publications

(62 reference statements)

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“…The relationship between pre‐operative tumour budding and the presence of extranodal tumour deposits, lymphovascular invasion, tumour grade and stage was also reported in colorectal cancer. In oral cancer, pre‐operative tumour budding had a significant prognostic value for lymph node metastasis, overall survival and relapse‐free survival . Pre‐operative tumour budding in oral cancer also had strong correlations with tumour grade, tumour depth and blood vessel invasion .…”

Section: Resultsmentioning

confidence: 92%

“…The findings of these studies (Table ) indicated that tumour budding is an evaluable histopathological parameter in biopsy specimens and could be used as a reliable prognosticator for patient survival. The studies evaluated tumour budding in pretreatment samples in the following cancers: five studies (four cohorts) on rectal cancer, two on colorectal cancer and three (two cohorts) on oral cancer . There was one study on breast cancer, one on epidermoid anal cancer and one on cancer of the external auditory canal …”

Section: Resultsmentioning

confidence: 99%

“…Recent and rapidly accumulating data indicate that tumour budding may open new perspectives for prognostication and treatment planning of many cancers . The prognostic value of tumour budding in diagnostic biopsies has been examined in recent studies . In addition, some of these studies reported the concordance of the score of tumour budding in pre‐operative diagnostic biopsy samples and postoperative surgical specimens .…”

Section: Introductionmentioning

confidence: 99%

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Does evaluation of tumour budding in diagnostic biopsies have a clinical relevance? A systematic review

et al. 2019

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Tumour budding has emerged as a promising prognostic marker in many cancers. We systematically reviewed all studies that evaluated tumour budding in diagnostic biopsies. We conducted a systematic review of PubMed, MEDLINE, Scopus, Web of Science and Cochrane library for all articles that have assessed tumour budding in diagnostic (i.e. pretreatment or pre‐operative) biopsies of any tumour type. Two independent researchers screened the retrieved studies, removed duplicates, excluded irrelevant studies and extracted data from the eligible studies. A total of 13 reports comprising 11 cohorts were found to have studied tumour budding in diagnostic biopsies. All these reports showed that evaluation of tumour budding in diagnostic biopsies was easily applicable. A strong association was observed between tumour budding score in diagnostic biopsies and corresponding surgical samples. Evaluation of tumour budding in diagnostic biopsies had a significant prognostic value for lymph node metastasis and patient survival. In all studies, tumour budding was a valuable marker of tumour aggressiveness and can be evaluated in technically satisfactory diagnostic biopsies. Thus, the assessment of tumour budding seems to identify the behaviour of cancer, and therefore to facilitate treatment planning.

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Section: Resultsmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Does evaluation of tumour budding in diagnostic biopsies have a clinical relevance? A systematic review

et al. 2019

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“…Recently, Seki et al . evaluated the tumour budding in biopsy specimens and verified that tumour budding was an independent factor for LNM and significantly related to the reduced relapse‐free survival, suggesting that prophylactic neck dissection should be considered when the tumour budding score is intermediate or high in pre‐operative biopsy specimens of cN0 early‐ stage OSCC …”

Section: Discussionmentioning

confidence: 93%

“…Other pathological characteristics of tumour cells in relation to the biological behaviour, including invasive depth and invasive pattern, have also been evaluated in many publications. However, the prognostic value of these parameters remains unresolved with conflicting reports in the literature . Furthermore, a BD model (a combination of tumour budding and invasive depth) has been suggested as a histopathological risk factor for recurrence in early‐stage TSCC and significantly associated with the outcome of OSCC …”

Section: Introductionmentioning

confidence: 99%

A novel prognostic model for tongue squamous cell carcinoma based on the characteristics of tumour and its microenvironment: iBD score

Wang

Zhuang

et al. 2019

Histopathology

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Aims Tumour budding and invasive depth can predict survival of patients with tongue squamous cell carcinoma (TSCC), while the prognostic value of tumour microenvironment (TME) remains unknown. Here, both characteristics of the tumour and its microenvironment were examined and a novel prognostic model has been proposed. Methods and results A total of 246 patients with TSCC were included. Using H&E‐stained sections, pathological parameters of tumour and the TME were assessed. Inflammatory response (i), tumour budding (B) and invasive depth (D) were combined as iBD score. The association between these variables and the patient survival was determined. Both tumour budding and inflammatory status were independent variables for predicting overall survival (OS) and disease‐free survival (DFS) of TSCC patients. Invasive depth was correlated with differentiation, T classification, lymph node metastasis, clinical stage and recurrence (P < 0.05). The novel iBD model was strongly correlated with T classification, lymph node metastasis, clinical stage and recurrence, and showed clear distinction of scores 0, 1 and 2. High iBD score had a strong association with reduced OS and DFS (P < 0.01). Conclusions The iBD scoring model is strongly associated with lymph node metastasis and recurrence in TSCC and could be a promising survival predictor for TSCC patients.

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Impact of tumor budding in head and neck squamous cell carcinoma: A meta‐analysis

et al. 2018

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Tumor budding (TB) has been suggested as an adverse prognostic factor in head and neck squamous cell carcinoma (HNSCC). This meta‐analysis evaluated the prognostic role of TB in HNSCC. We systematically reviewed the literatures of electronic databases and performed a meta‐analysis to address the impact of TB on prognosis in HNSCC. Published data were extracted and organized. Then, pooled odds ratios for lymph node metastasis (LNM) and hazard ratios for survival were calculated by using the Mantel‐Haenszel fixed effect model. The results showed that high TB was significantly associated with LNM and worse survival in patients with HNSCC. Moreover, high TB was also correlated with poor prognosis in patients with cT1‐2N0 oral squamous cell carcinoma. TB is a promising prognostic factor associated with LNM and worse survival, which should be included in the routine pathological examination of HNSCC.

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Tumour budding evaluated in biopsy specimens is a useful predictor of prognosis in patients with cN0 early stage oral squamous cell carcinoma

Abstract: The assessment of tumour budding is effective in predicting prognosis in cN0 early stage OSCC. In T1/2 stage and cN0 cancer, prophylactic neck dissection to prevent LNM should be considered when the tumour budding score regarding pre-operative biopsy specimens is intermediate or high.

Cited by 50 publications

References 23 publications

Does evaluation of tumour budding in diagnostic biopsies have a clinical relevance? A systematic review

Does evaluation of tumour budding in diagnostic biopsies have a clinical relevance? A systematic review

A novel prognostic model for tongue squamous cell carcinoma based on the characteristics of tumour and its microenvironment: iBD score

Impact of tumor budding in head and neck squamous cell carcinoma: A meta‐analysis

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