Aims
Tumour budding and invasive depth can predict survival of patients with tongue squamous cell carcinoma (TSCC), while the prognostic value of tumour microenvironment (TME) remains unknown. Here, both characteristics of the tumour and its microenvironment were examined and a novel prognostic model has been proposed.
Methods and results
A total of 246 patients with TSCC were included. Using H&E‐stained sections, pathological parameters of tumour and the TME were assessed. Inflammatory response (i), tumour budding (B) and invasive depth (D) were combined as iBD score. The association between these variables and the patient survival was determined. Both tumour budding and inflammatory status were independent variables for predicting overall survival (OS) and disease‐free survival (DFS) of TSCC patients. Invasive depth was correlated with differentiation, T classification, lymph node metastasis, clinical stage and recurrence (P < 0.05). The novel iBD model was strongly correlated with T classification, lymph node metastasis, clinical stage and recurrence, and showed clear distinction of scores 0, 1 and 2. High iBD score had a strong association with reduced OS and DFS (P < 0.01).
Conclusions
The iBD scoring model is strongly associated with lymph node metastasis and recurrence in TSCC and could be a promising survival predictor for TSCC patients.
LDPE nanodielectrics show good space charge suppression performances, reducing the electric field distortions and improving the electric strengths. The decrease of space charge accumulation of LDPE nanodielectrics with increasing the nanoparticle loadings can be explained by the reduction of charge injection, the enhancement of conduction, and so on. However, the phenomena that the conductivities of LDPE nanodielectrics decrease firstly and then may increase with increasing the nanoparticle loadings has not been fully understood. A bipolar charge transport model consisting of charge injection, charge migration, and charge trapping, detrapping, recombination dynamics is used to investigate the space charge accumulation and conduction properties of LDPE nanodielectrics. Based on simulation results and existing experimental results, we discuss the influencing factors for space charge accumulation and conduction properties of LDPE nanodielectrics. It is found that the heightening of injection barrier plays a more important role in the suppression of space charges and the reduction of conductivities of LDPE nanodielectrics. Whereas, the variation of trap density and trap energy will regulate the nanoparticle loading dependent conduction properties.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.