Tumour‐associated macrophages might represent a favourable prognostic indicator in patients with papillary renal cell carcinoma

Abstract

The presence of TAM was shown independently to reduce the risk of death from cancer by 55%. The presence of TAM should therefore become part of routine pathology reporting in PRCC.

Prognostic role of lymphocyte to monocyte ratio for patients with cancer: evidence from a systematic review and meta-analysis

“…Macrophages, which are more differentiated monocytes, develop from cells of the mononuclear phagocytic lineage and show specific phenotypic characteristics. The role of macrophages/monocytes in cancer development and progression is disputed, since they have inhibiting as well as enhancing potential of monocytes in human cancer [77]. Nevertheless, there is increasing evidence that the tumor-associated macrophages (TAMs) enhance tumor progression.…”

The lymphocyte to monocyte ratio in peripheral blood represents a novel prognostic marker in patients with pancreatic cancer

“…In this context, macrophages, which develop from cells of the mononuclear phagocytic lineage, are more differentiated monocytes and show specific phenotypic characteristics. The role of macrophages/monocytes in cancer progression and development is controversially discussed, since they have inhibiting as well as enhancing potential in human cancer [34]. However, there is increasing evidence, that the tumor-associated macrophages (TAMs) enhance tumor progression.…”

Pretreatment lymphocyte–monocyte ratio as a potential prognostic factor in a cohort of patients with upper tract urothelial carcinoma

“…Influencing T-lymphocytes by immune checkpoint blockade inhibitors (eg, ipilimumap) carries a huge therapeutic potential and is currently under clinical investigation for several tumour types. On the other hand, tumour-associated macrophages (TAM) developing from mononuclear cell lineages have been demonstrated to being able to inhibit, as well as to facilitate, cancer progression and spread of metastatic tumours 22 23. Bingle and colleagues were able to demonstrate an association between high macrophage density and poor clinical outcomes in various types of human cancer, such as breast, lung, cervix, prostate, as well as urothelial carcinoma of the bladder 24.…”