Tumour Angiogenesis and Angiogenic Inhibitors: A Review

Yadav, Lalita

doi:10.7860/jcdr/2015/12016.6135

Cited by 132 publications

(149 citation statements)

References 38 publications

Supporting

Mentioning

128

Contrasting

Unclassified

Order By: Relevance

“…The most important proangiogenic factor is VEGF and its activation may be positively regulated by EGFR. 31 We found that MVD showed a tendency to increase from NOM to OSCC. This difference was significant when comparing MVD of NOM and OSCC diagnoses and the diagnosis of OED and OSCC.…”

mentioning

confidence: 77%

Difference in EGFR expression and mean vascular density in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma.

Fernández¹,

Fernández

Marshall

et al. 2017

J Oral Res

View full text Add to dashboard Cite

To evaluate the expression of the epidermal growth factor receptor (EGFR) and mean vascular density (MVD) in normal oral mucosa (NOM), oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). Material and methods: Descriptive case study. Nineteen histological samples diagnosed with NOM, 18 diagnosed with OED, and 19 with OSCC, were analyzed with immunohistochemistry against EGFR and CD31. EGFR expression was evaluated by extent and intensity of its expression in normal, dysplastic and neoplastic epithelium. MVD was determined through the detection of blood vessels by antibodies against CD31. Results: Extension of EGFR expression was highest in OSCC followed by OED and lowest in NOM, resulting in significant different between the degrees of extension (p<0.001). Intensity of EGFR was similar in NOM, OED and OSCC, without differences in its expression (p=0.533). Differences in MVD were found between NOM and OSCC groups (p<0.01), and between OED and OSCC groups (p<0.01), with no differences between NOM and OED groups (p=0.91). MVD was 21.17±4.98 in NOM, 23.40±5.77 in OED and 33.92±8.39 in OSCC. Conclusion: EGFR is expressed in normal, dysplastic or neoplastic oral epithelium. However, the extent of its expression is greater as malignancy increases. MVD varies according to the diagnosis.

show abstract

mentioning

confidence: 77%

Difference in EGFR expression and mean vascular density in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma.

Fernández¹,

Fernández

Marshall

et al. 2017

J Oral Res

View full text Add to dashboard Cite

show abstract

“…Several effective anti-angiogenic drugs are now available and several are under development and, in order to improve the individualization of cancer treatment, blood-based biomarkers that accurately reflect their effects are urgently required (61)(62)(63). Numerous reports suggest that serial counting of CECs and/or EPCs can be successfully used to this end, however, this interesting prospect needs to be fully corroborated in the clinical setting, first of all by overcoming the areas of controversy that persist in the study of CEC and EPC biology.…”

Section: Discussionmentioning

confidence: 99%

Flow cytometric analysis of circulating endothelial cells and endothelial progenitors for clinical purposes in oncology: A critical evaluation

Danova

Comolli

Manzoni

et al. 2016

Molecular and Clinical Oncology

View full text Add to dashboard Cite

Abstract. Malignant tumors are characterized by uncontrolled cell growth and metastatic spread, with a pivotal importance of the phenomenon of angiogenesis. For this reason, research has focused on the development of agents targeting the vascular component of the tumor microenvironment and regulating the angiogenic switch. As a result, the therapeutic inhibition of angiogenesis has become an important component of anticancer treatment, however, its utility is partly limited by the lack of an established methodology to assess its efficacy in vivo. Circulating endothelial cells (CECs), which are rare in healthy subjects and significantly increased in different tumor types, represent a promising tool for monitoring the tumor clinical outcome and the treatment response. A cell population circulating into the blood also able to form endothelial colonies in vitro and to promote vasculogenesis is represented by endothelial progenitor cells (EPCs). The number of both of these cell types is extremely low and they cannot be identified using a single marker, therefore, in absence of a definite consensus on their phenotype, require discrimination using combinations of antigens. Multiparameter flow cytometry (FCM) is ideal for rapid processing of high numbers of cells per second and is commonly utilized to quantify CECs and EPCs, however, remains technically challenging since there is as yet no standardized protocol for the identification and enumeration of these rare events. Methodology in studies on CECs and/or EPCs as clinical biomarkers in oncology is heterogeneous and data have been obtained from different studies leading to conflicting conclusions. The present review presented a critical review of the issues that limit the comparability of results of the most significant studies employing FCM for CEC and/or EPC detection in patients with cancer.

show abstract

“…Angiogenesis is the development of new blood vessels from pre-existing vessels; this process is required for embryogenesis, normal tissue development, wound healing and tumor growth [1]. However, based on accumulating evidence, vascular endothelial cells in tumors are different from normal endothelial cells [2].…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Endothelial Nogo-B suppresses cancer cell proliferation via a paracrine TGF-β/Smad signaling

Li¹,

Cheng²,

Huang³

et al. 2018

Oncotarget

View full text Add to dashboard Cite

show abstract

Tumour Angiogenesis and Angiogenic Inhibitors: A Review

Cited by 132 publications

References 38 publications

Difference in EGFR expression and mean vascular density in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma.

Difference in EGFR expression and mean vascular density in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma.

Flow cytometric analysis of circulating endothelial cells and endothelial progenitors for clinical purposes in oncology: A critical evaluation

WITHDRAWN: Endothelial Nogo-B suppresses cancer cell proliferation via a paracrine TGF-β/Smad signaling

Contact Info

Product

Resources

About