Tumors of the Thyroid Gland: Histologic and Cytologic Features - Part 1

Muro-Cacho, Carlos; Ku, Ni Ni

doi:10.1177/107327480000700311

Cited by 8 publications

(8 citation statements)

References 21 publications

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“…6 Despite the fact that the gross appearance of minimally invasive follicular carcinoma is similar to follicular adenoma, it is distinguished from follicular adenoma by the presence of vascular and/or capsular invasion. 7 The differential diagnosis of follicular variant of papillary thyroid carcinoma from follicular adenoma is based on the finding of appropriate nuclear features of papillary thyroid carcinoma such as nuclear enlargement, elongation, chromatin clearing, nuclear grooves, and pseudoinclusions. 8 Because of the fact that neither vascular and capsular invasion nor nuclear changes were present in the present case, the lesion was diagnosed as follicular adenoma.…”

Section: Discussionmentioning

confidence: 99%

Ectopic Thyroid Tissue with Follicular Adenoma Mimicking Carotid Body Tumor

Akçam¹,

Talaş²,

Gerek³

et al. 2004

Otolaryngol.--head neck surg.

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Section: Discussionmentioning

confidence: 99%

Ectopic Thyroid Tissue with Follicular Adenoma Mimicking Carotid Body Tumor

Akçam¹,

Talaş²,

Gerek³

et al. 2004

Otolaryngol.--head neck surg.

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“…In general, 5% to 8% of aspirates are diagnostic of malignancy, 10% to 20% are considered suspicious but not diagnostic (demonstrating microfollicular cytology), 2% to 5% fail to provide an adequate specimen, and the remainder are considered benign, usually suggestive of a "colloid nodule" or thyroiditis. 6 An inadequate specimen should lead to reaspiration. A biopsy of nonpalpable nodules can be performed under ultrasound guidance.…”

Section: Physical Findingsmentioning

confidence: 99%

Evaluation of the Thyroid Nodule

McCaffrey

2000

Cancer Control

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“…HLA-E has been known to affect the clinical outcome of various tumor types because its interaction with the CD94/NKG2A receptor inhibits the potent anticancer activity of NK cells. Due to the high phenotypic heterogeneity of thyroid tumors (17,18), the evaluation of HLA-E in these tumors is an important tool for exploring the process of thyroid neoplasm progression. Based on this evidence, we evaluated the immunohistochemical expression of HLA-E in neoplastic and non-neoplastic lesions to determine the expression pattern among different tumor types and to analyze the impact of HLA-E expression on clinical outcomes.…”

mentioning

confidence: 99%

Differential Expression of Immune-Modulatory Molecule HLA-E in Non-Neoplastic and Neoplastic Lesions of the Thyroid

Zanetti

Carvalho-Galano

Feitosa

et al. 2013

Int J Immunopathol Pharmacol

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Human leukocyte antigen (HLA)-E is a non-classical molecule ofthe histocompatibility complex that functions as one of the main ligands of the Natural Killer (NK) cell inhibitory receptor CD94INKG2A and inhibits its potent cytotoxic activity. Due to the important role of NK cells in combating neoplasm, we hypothesized that the differential expression of HLA-E could favor the progression of heterogeneous thyroid tumors. Using an immunohistochemistry technique in 143 biopsies of thyroid tumors, including benign and malignant neoplasms and goiters, we evaluated the expression of HLA-E among various tumor types and its association with the clinicopathological factors of diseases. We verified high HLA-E expression in all types of neoplastic tumors, although no significant differences between the groups were found. Low expression was observed in 95% of the goiter samples, showing significant differences between neoplastic and non-neoplastic lesions. Furthermore, a significant result was found with regard to the tumor size, with high HLA-E expression being related to smaller tumors. Therefore, our data suggest that an increase in HLA-E may be associated with the establishment of thyroid neoplasms, with either benign or malignant features.

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Tumors of the Thyroid Gland: Histologic and Cytologic Features - Part 1

Cited by 8 publications

References 21 publications

Ectopic Thyroid Tissue with Follicular Adenoma Mimicking Carotid Body Tumor

Ectopic Thyroid Tissue with Follicular Adenoma Mimicking Carotid Body Tumor

Evaluation of the Thyroid Nodule

Differential Expression of Immune-Modulatory Molecule HLA-E in Non-Neoplastic and Neoplastic Lesions of the Thyroid

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