Tumors of the Cerebral Hemispheres in Children

Low, Niels L.; Correll, James W.; Hammill, James F.

doi:10.1001/archneur.1965.00470050095012

Cited by 37 publications

(8 citation statements)

References 8 publications

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“…Nevertheless seizures are the first manifestation of brain tumors in 11-50% of children and adults [16,17,[18][19][20][21]. In our study, only 14% of our CBTC children with central nervous system tumors had seizures.…”

Section: Discussionmentioning

confidence: 51%

Epidemiology of seizures in children with brain tumors

Sobel

Leviton

et al. 1992

J Neuro-Oncol

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We examined potential clinical and pathologic correlates of seizures among the 3,291 children in the Childhood Brain Tumor Consortium database. Fourteen percent had seizures prior to their hospitalization for a brain tumor. Among children who had a supratentorial tumor, seizures occurred in 22% of those less than 14 years of age. The prevalence of seizures increased to 68% of older teenagers. Among children with an infratentorial tumor, the prevalence of seizures was relatively constant at 6% over all age groups. The onset of seizures began more than one year prior to surgical tumor removal in over half of the children aged five or more with supratentorial tumors, significantly longer than for those of the same age with infratentorial tumors. Almost all children (98.9%) with an infratentorial tumor and seizures had at least one other symptom and more than three-fourths of them had at least three. Eighty-nine percent of children with a supratentorial tumor and seizures had at least one other symptom and more than one-half had at least three symptoms. Regardless of whether the tumor was above or below the tentorium, confusion or stupor and coma were more common in children with seizures than in children without seizures. Among children with supratentorial tumors, symptoms of a declining academic performance or an abnormality of personality, speech, walking, or sensation were significantly more frequent in children with seizures, while visual symptoms (other than visual loss or diplopia) and nausea or vomiting were less frequent. Among children with supratentorial tumors, those who had seizures were more likely to have paralysis of an arm, hand, or face, confusion or stupor, or coma and less likely to exhibit irritability, papilledema, optic atrophy, decreased visual acuity, pupillary abnormalities, or abducens paresis. Among children with infratentorial tumors, those with seizures were significantly less likely to have truncal ataxia, but more likely to experience confusion, stupor, or coma. In the supratentorial compartment, astrocytoma (nos), protoplasmic astrocytoma, anaplastic astrocytoma, and ependymoma were more frequently associated with seizures than was craniopharyngioma. No infratentorial tumor type was more or less likely to be associated with seizures. All common tumor types that were represented in both the supratentorial and the infratentorial compartment except astrocytoma (nos) were associated with significantly greater rates of seizures when located in the supratentorial compartment. The tumor location with the highest incidence of seizures was, as expected, the superficial cerebrum. More than 40% of the children with such tumors had seizures.(ABSTRACT TRUNCATED AT 400 WORDS)

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Section: Discussionmentioning

confidence: 51%

Epidemiology of seizures in children with brain tumors

Sobel

Leviton

et al. 1992

J Neuro-Oncol

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“…Prior to the advent of CT. neuroradiologic assessment consisted of cerebral an giography and pneumoencephalography. There was often a long interval between seizure onset and a diagnosis which could lead to a surgical treatment [28]. Newer imaging techniques have demonstrated previously unde tectable lesions [29].…”

Section: Discussionmentioning

confidence: 99%

“…[28] noted that the diagnosis of tumors in patients with seizures was delayed for > 3 years in 36% of cases. With some cases of chronic seizures extending over 10 years, it has been postulated that these neoplastic lesions may in fact have arisen from hamartomas which were present prior to the onset of the seizures [47], The finding of a significant percentage of hamartomas (the predominant pathologic diagnosis among the neoplasms) and gangliogliomas was noted in our series as well as in the literature [3,22,24,27,28,46]. Gliomas accounted for only 38% of the tumors, a finding similar to those of Rasmussen [ 14], Goldring [30], Blume et al [3], and Meyer et al [22].…”

Section: Discussionmentioning

confidence: 99%

Temporal and Extended Temporal Resections for the Treatment of Intractable Seizures in Early Childhood

Ht³

et al. 1992

Pediatr Neurosurg

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In our series of 33 children who underwent temporal and extended temporal lobe resections because of seizures, the average age at surgery was 7 years, 11 months. Sixteen cases (48%) were diagnosed as having tumors: low-grade astrocytoma (6), hamartoma (5), and ganglioglioma/neuroma (5). Other pathologic diagnoses included one or more cytoarchitectural abnormalities and/or reactive changes. Due to a more aggressive and early radiologic and electrophysiologic investigation of children with seizures, a resectable focus, e.g. neoplasm or structural abnormality, was found in a much younger age group of patients than previously reported. In children who had intractable seizures but normal radiologic studies, positron emission tomography was of great value in localizing the seizure focus. In a group of children with infantile spasms, seizures were controlled following the identification and resection of a focal lesion. Prompt detection and precise localization of lesions in the temporal lobe in the pediatric population may lead to surgical management and seizure control.

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“…To this must be added the variations in age limits used for childhood which sometimes comprise ages from 0-12 years, and sometimes ages from 0-20 years (Bergstrand et al 1958, Troupp 1960, Heppner 1965, Rrayenbiihl 1965, Low et al 1965, Ruth 1965, Jenkiri 1969, Jellinger & Seitelberger 1970, Abrahamson et al 1974, Martins et al 1974. To this must be added the variations in age limits used for childhood which sometimes comprise ages from 0-12 years, and sometimes ages from 0-20 years (Bergstrand et al 1958, Troupp 1960, Heppner 1965, Rrayenbiihl 1965, Low et al 1965, Ruth 1965, Jenkiri 1969, Jellinger & Seitelberger 1970, Abrahamson et al 1974, Martins et al 1974.…”

mentioning

confidence: 99%

“…The lack of uniformity in the histological classification of these tumours has made it difficult or impossible to compare the various materials. To this must be added the variations in age limits used for childhood which sometimes comprise ages from 0-12 years, and sometimes ages from 0-20 years (Bergstrand et al 1958, Troupp 1960, Heppner 1965, Rrayenbiihl 1965, Low et al 1965, Ruth 1965, Jenkiri 1969, Jellinger & Seitelberger 1970, Abrahamson et al 1974, Martins et al 1974.…”

mentioning

confidence: 99%

MALIGNANCY GRADE and LONG-TERM SURVIVAL IN BRAIN TUMOURS of INFANCY and CHILDHOOD

Gjerris¹,

Klee²,

Klinken³

1976

Acta Neurologica Scandinavica

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281 histologically verified brain tumours in children were revised and reclassified according to degree of histological malignancy. Survival graphs based on 100 per cent follow-up after 15-40 years show that, of those who survived for more than 1 month after diagnosis and possible operation, 40 per cent were still alive more than 15 years later. There was a clear correlation between survival and degree of malignancy. Sixty-five per cent of those with tumours of malignancy grade I and only 3 per cent of those with malignancy grade IV were alive after 15 years.

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Tumors of the Cerebral Hemispheres in Children

Cited by 37 publications

References 8 publications

Epidemiology of seizures in children with brain tumors

Epidemiology of seizures in children with brain tumors

Temporal and Extended Temporal Resections for the Treatment of Intractable Seizures in Early Childhood

MALIGNANCY GRADE and LONG-TERM SURVIVAL IN BRAIN TUMOURS of INFANCY and CHILDHOOD

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