Tumors metastatic to the orbit: A changing picture

Goldberg, Robert A.; Rootman, Jack; Cline, Roy A.

doi:10.1016/0039-6257(90)90045-w

Cited by 294 publications

(259 citation statements)

References 124 publications

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“…[1,2] Most common causes of metastasis to orbit are breast, prostate, lung and kidney; they make 60-70% of all cases metastasizing to orbit; other causes of orbital metastasis have been reported in various tumor located at different sites such as skin, stomach, bone, pleura, gall bladder and testis. [1,3,6] In our study four patients (44.4%) had adenocarcinoma, two patients (22.2%) had adenoid cystic carcinoma of salivary glands and one patient (11.1%) each had malignant lymphoma, osteosarcoma and papillary carcinoma thyroid in histopathology.…”

Section: Discussionsupporting

confidence: 42%

“…[1] These metastatic deposits may precede symptoms of primary in many cases like in lung, gastrointestinal, thyroid and renal cancers. [2,3]Some cases of carcinoma breast present with orbital metastasis after completing treatment for the primary. [2,3] Now a day evaluation for unknown primary in case of metastases is relatively easy with advancement in technology.…”

Section: Introductionmentioning

confidence: 99%

“…[2,3]Some cases of carcinoma breast present with orbital metastasis after completing treatment for the primary. [2,3] Now a day evaluation for unknown primary in case of metastases is relatively easy with advancement in technology. Nevertheless, in some cases the primary remains unknown until the tumor present as metastasis elsewhere.…”

Section: Introductionmentioning

confidence: 99%

“…In most cases identification of primary do not alter overall outcome but some survival advantage can be seen in lymphoma, breast carcinoma and uterine malignancies. [3,6] In this study we present our experiences of orbital metastasis in nine patients with review of literature regarding their presentation and prognosis. All these patients presented to our department primarily with orbital symptoms with unknown primary.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Orbital Metastasis An Analysis of Nine Cases And Review of Literature

Bhaisora¹,

Sahu²,

Singh³

et al. 2017

IOSR JDMS

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Section: Discussionsupporting

confidence: 42%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Orbital Metastasis An Analysis of Nine Cases And Review of Literature

Bhaisora¹,

Sahu²,

Singh³

et al. 2017

IOSR JDMS

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“…In 25% of these, it is the presenting sign of malignancy. [1][2][3][4] Frequently, this presents a diagnostic challenge and represents a poor prognosis. 5 We present an unusual case of proptosis as the index sign of malignancy and review the literature surrounding orbital and ocular metastases in prostate cancer and renal cell carcinoma (RCC).…”

Section: Introductionmentioning

confidence: 99%

Genitourinary malignancy presenting as an ocular metastasis: A case report and review of the literature

Lefresne¹,

Fairchild²,

Johnson³

et al. 2012

CUAJ

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E67Case report Genitourinary malignancy presenting as an ocular metastasis: A case report and review of the literature Cite as: Can Urol Assoc J 2012;6(2):e67-71. http://dx.doi.org/10.5489/cuaj.10174 AbstractMetastases to the eye or orbit as the initial presentation of genitourinary malignancy are unusual and can be a diagnostic challenge. We report an 81-year-old man who presented with pain and proptosis in an eye that had been blind for 50 years. Radiologic investigations identified a mass involving the left globe and orbit. Histology of the enucleation specimen was consistent with a metastatic poorly differentiated carcinoma suggestive of a prostate primary. With the constellation of obstructive urinary symptoms, an abnormal digital rectal examination, elevated prostate-specific antigen and a positive bone scan, androgen deprivation therapy was initiated for metastatic prostate cancer. After an initial response to treatment, the patient's disease progressed in a manner atypical for prostate cancer. After describing our case, we review the literature on ocular and orbital metastases and their relation to genitourinary malignancies.

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Orbital Metastasis Due to Interval Lobular Carcinoma of the Breast

Wolstencroft¹,

Hodder²,

Askill³

et al. 1999

Arch Ophthalmol

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A 53-year-old woman had an orbital mass composed of a neoplastic small round cell infiltrate and no apparent extraorbital primary tumor. Although the initial diagnosis was primary orbital lymphoma, a combination of mucin histochemistry and immunohistochemical staining for cytokeratin and estrogen receptors led to the discovery of an impalpable lobular carcinoma of the breast. We discuss how detailed histopathological assessment can lead to beneficial therapy.

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Tumors metastatic to the orbit: A changing picture

Cited by 294 publications

References 124 publications

Orbital Metastasis An Analysis of Nine Cases And Review of Literature

Orbital Metastasis An Analysis of Nine Cases And Review of Literature

Genitourinary malignancy presenting as an ocular metastasis: A case report and review of the literature

Orbital Metastasis Due to Interval Lobular Carcinoma of the Breast

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