Genitourinary malignancy presenting as an ocular metastasis: A case report and review of the literature

Lefresne, Shilo; Fairchild, Alysa; Johnson, Royce H.; Deschênes, Jean; Russell, Laurie; Pederson, John M.

doi:10.5489/cuaj.163

Cited by 2 publications

(2 citation statements)

References 37 publications

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“…Bone metastases are usually predominantly osteoblastic (95%). 7,8 The detection of orbital lesions starting from a solid cancer is still considered a challenging task due to their wide variety of anatomical and clinical features. Indeed, orbital metastases may be intraconal or extraconal and may present different patterns, from a focal lesion to a massive infiltrative one.…”

Section: Resultsmentioning

confidence: 99%

Orbital metastasis as presenting symptom from a prostatic adenocarcinoma

Pastore

D’Aloisio

Cirigliano

et al. 2019

European Journal of Ophthalmology

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Purpose: To report a 72-year-old man with orbital metastasis as presenting symptoms from a prostatic adenocarcinoma. Methods: A complete ophthalmological evaluation with ultrasonography examination, kinetic perimetry, fluorescein angiography, and visually evoked potentials were performed. The patient underwent computed tomography, magnetic resonance imaging of the orbit, and blood test for confirmation of the diagnosis. Bone infiltration rate of the cancer was evaluated with bone scintigraphy. Type of the tumor was assessed with orbital incision biopsy and histological analysis. The patient received systemic chemotherapy. Due to poor patient compliance, radiotherapy was not performed. Results: Ultrasonography showed a hypoechoic retrobulbar lesion. At computed tomography examination of the orbit an expansive oval intraconical solid lesion with enhancement after medium contrast was found. Biopsy findings revealed a moderately differentiated adenocarcinoma with immunohistochemical profile supporting prostate as the primary tumor site: negative for cytokeratin-7 and cytokeratin-20 and positive for prostate-specific antigen, prostate-specific acid phosphatase, and alpha-methylacyl-CoA-racemase. Conclusions: Ocular signs and symptoms as first clinical presentation of a prostate cancer are relatively rare. Despite its very poor prognosis, a correct management and therapy can improve visual acuity, ocular symptoms, and median survival of cancer patients.

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Section: Resultsmentioning

confidence: 99%

Orbital metastasis as presenting symptom from a prostatic adenocarcinoma

Pastore

D’Aloisio

Cirigliano

et al. 2019

European Journal of Ophthalmology

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“…In this study, we present the largest case series so far of patients with rare optic canal metastases due to PCa. Our study identified 45 cases of metastatic PCa with optic canal involvement reported in the literature [ 4 - 30 ]. We engage in an analysis of their clinical characteristics, notable histology, and treatment modalities.…”

Section: Introductionmentioning

confidence: 99%

Metastatic Prostate Cancer to the Optic Canal: A Large-Cohort Analysis

Kelkar,

Findakly,

Wang

2023

Cureus

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Prostate cancer (PCa) can present with metastases in rare cases, including those to the optic canal. Currently, no guidelines exist for managing PCa metastases in this patient population. This article aims to examine optic canal metastases through a large-cohort analysis. It involves a systematic review of the literature through a pooled analysis of published cases of PCa with optic canal or orbital metastasis, including one case previously reported from our institution. A subgroup analysis was employed to compare cases with optic metastases as their initial PCa presentation, hormone-naive (HN), versus those with optic metastases after PCa diagnosis, hormone-refractory (HR). A total of 45 patients with ocular metastasis from PCa were included in this study. The mean age at diagnosis overall was 66.8 years (range: 45-85 years). Moreover, 16 cases (50%) had deceased, with a median time-to-death of 22 (range: 2-84) months. Regarding subgroup analysis, the mean age at diagnosis was 69.5 years (53-85 years) in the HN group and 64.5 years (45-83 years) in the HR group. With regard to reported survival, 10 (62.5%) cases belonged to the HN subset with a median follow-up duration of 12 (range: 1.5-36) months. In terms of reported mortality, 10 (62.5%) were from the HR subset with a median time-to-death of 32.5 (range 0.5-84) months. Our study constitutes the largest and most comprehensive examination of patients with optic canal metastases due to PCa so far. While optic canal metastases are a rare manifestation of PCa, they are linked with a poor prognosis. We also observed significant differences between HR and HN cohorts, which may indicate a difference in clinical presentations.

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Genitourinary malignancy presenting as an ocular metastasis: A case report and review of the literature

Cited by 2 publications

References 37 publications

Orbital metastasis as presenting symptom from a prostatic adenocarcinoma

Orbital metastasis as presenting symptom from a prostatic adenocarcinoma

Metastatic Prostate Cancer to the Optic Canal: A Large-Cohort Analysis

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