Tumors and biofilms: too much coincidences to be casual

Verevka, Serhij; Voroshylova, Natalia

doi:10.7124/bc.000972

Biopolym. Cell

2018

DOI: 10.7124/bc.000972

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Tumors and biofilms: too much coincidences to be casual

Serhij Verevka

Natalia Voroshylova

Abstract: Biofilms are complex systems that have high cell density, ranging from 10 8 to 10 11 cells g-1

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Cited by 5 publications

(4 citation statements)

References 26 publications

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“…Such processes are observed both for pathological changes, and for the normal state of many living organisms [25]. The relationship between similar parametabolic reactions is considered in detail on the example of biofilms' formation [26].…”

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confidence: 99%

Aggregated proteins in malignant and benign neoplasms

et al. 2023

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Summary. Aim: To evaluate the presence of the aggregated proteins in malignant and benign neoplasms for clarifying the role of impaired protein metabolism in the formation of the altered tissues. Object and Methods: The histological specimens prepared from the operative materials of 196 patients with different forms of malignant and benign neoplasms were stained with Congo red and Thioflavin T and studied under the light and polarization microscope. Results: The various forms of β-stacked protein aggregates (β-SPA) inclusions were detected in amyloids, keloid tissue, benign polyps, and several malignant tumors. Conclusion: The formation of non-functional protein aggregates proves the complex character of the impairment of protein metabolism resulting in local or systemic accumulation of secondary protein toxins results in β-SPA formation as the self-sustaining complex of parametabolic processes. The β-SPA formation is of considerable interest since their properties lead to the impairment of the normal physiological processes in adjacent tissues ensuring the chronic course of the pathology.

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confidence: 99%

Aggregated proteins in malignant and benign neoplasms

et al. 2023

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“…There is a certain analogy in the structure and functioning of multicellular associates of microorganisms and cells of malignant tumors [13]. The intercellular polymeric substance of BF and the stroma of malignant tumors are similar in composition and play an important role in the functioning of the corresponding associates.…”

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Malignization as a Consequence of the Formation of Microbial Resistance

Zabolotnyi

Kizim²,

Zabolotna³

et al. 2023

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The ability of microorganisms to form multicellular three-dimensional associates (biofilms) increases significantly their resistance to the influence of negative environmental factors. One of the manifestations of this ability is the development of drug resistance, which leads to a decrease in the effectiveness of drugs and significantly complicates the treatment of the corresponding diseases. Despite the unabated interest in this extremely undesirable phenomenon, there is no generally accepted explanation of the mechanisms of resistance development. At the same time, the generalization of data on the properties of biofilms allows us to get closer to the understanding of this process, but also to substantiate the proposition about its negative impact on adjacent tissues.

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“…The basis of this process is the ability of cells of pathogenic microorganisms and malignant neoplasms to accelerate mutation with the acquisition of increased resistance to the action of drugs [1,2]. There are certain analogies between biofilms of microorganisms and tumors of malignant neoplasms [3]. Intercellular substance plays an important role in both systems.…”

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confidence: 99%

Depolarization of Cell Membranes in the Formation of Drug Resistance

Voroshylova¹,

Kizim²,

Verevka³

2022

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Correlation of the properties of biofilms of microorganisms and malignant tumors indicates the existence of a certain analogy between them, which allows us to explain the essential circumstances of the formation of drug resistance. Intercellular substance plays a significant role in the functioning of both types of cell groups. Both types are characterized by the formation and local accumulation of structurally damaged proteins and peptides. The regularity of their interaction with membrane’s phospholipid bilayer creates prerequisites for the formation of β-structured inclusions that are characterized by electrical conductivity. This leads to membrane depolarization and, as a result, to disruption of its barrier function. An increase in the permeability of the membrane contributes to the entry of external genetic material, the formation of mutated forms and the development of drug resistance.

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Tumors and biofilms: too much coincidences to be casual

Abstract: Biofilms are complex systems that have high cell density, ranging from 10 8 to 10 11 cells g-1

Cited by 5 publications

References 26 publications

Aggregated proteins in malignant and benign neoplasms

Aggregated proteins in malignant and benign neoplasms

Malignization as a Consequence of the Formation of Microbial Resistance

Depolarization of Cell Membranes in the Formation of Drug Resistance

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