Tumors and Aging: The Influence of Age-Associated Immune Changes Upon Tumor Growth and Spread

Differences between naive and memory T cell phenotype in Malawian and UK adolescents: a role for Cytomegalovirus?

“…Among several factors known to be associated with such changes is seropositivity to persistent viral infections such as cytomegalovirus (CMV) [ 10 ]. CMV infection is known to drive T cells toward oligoclonality, end-stage differentiation and replicative senescence [ 11 , 12 ], which, in elderly individuals, may contribute to increased susceptibility to infectious, neoplastic and degenerative diseases [ 13 , 14 ].…”

Meeting Report: Breast Cancer in the Older Woman

“…It is reasonable to expect to find a higher prevalence of indolent tumors in older individuals, for a process of natural selection 19 • The mechanism of selection is illustrated in Figure 1. Two women start developing breast cancer at age 35, and one of them has a very aggressive tumor capable of killing her when she is 39, the other has a very indolent tumor that does not become manifest until age 65 and would not kill her until age 75.…”