Epidemiology of Cancer and Aging

Balducci, Lodovico; Aapro, Matti

doi:10.1007/0-387-23962-6_1

Cited by 59 publications

(55 citation statements)

References 44 publications

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“…During the next 10 years, 70% of patients with cancer will be older than 65 years of age. 1 The association of a cancer history with adverse health outcomes in the elderly population is important to assess to provide these patients with comprehensive care.…”

Section: Introductionmentioning

confidence: 99%

Association of Cancer With Geriatric Syndromes in Older Medicare Beneficiaries

Mohile

Fan

Reeve

et al. 2011

JCO

197

112

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A B S T R A C T PurposeTo identify whether a history of cancer is associated with specific geriatric syndromes in older patients. Patients and MethodsUsing the 2003 Medicare Current Beneficiary Survey, we analyzed a national sample of 12,480 community-based elders. Differences in prevalence of geriatric syndromes between those with and without cancer were estimated. Multivariable logistic regressions were used to evaluate whether cancer was independently associated with geriatric syndromes. ResultsTwo thousand three hundred forty-nine (18%) reported a history of cancer. Among those with cancer, 60.3% reported one or more geriatric syndromes as compared with 53.2% of those without cancer (P Ͻ .001). Those with cancer overall had a statistically significantly higher prevalence of hearing trouble, urinary incontinence, falls, depression, and osteoporosis than those without cancer. Adjusting for possible confounders, those with a history of cancer were more likely to experience depression (adjusted odds ratio [OR], 1.15; 95% CI, 1.02 to 1.30; P ϭ .023), falls (adjusted OR, 1.17; 95% CI, 1.04 to 1.32; P ϭ .010), osteoporosis (adjusted OR, 1.21; 95% CI, 1.06 to 1.38; P ϭ .004), hearing trouble (adjusted OR, 1.28; 95% CI, 1.08 to 1.52; P ϭ .005), and urinary incontinence (adjusted OR, 1.42; 95% CI, 1.20 to 1.69; P Ͻ .001). Analysis of specific cancer subtypes showed that lung cancer was associated with vision, hearing, and eating trouble; prostate cancer was associated with incontinence and falls; cervical/uterine cancer was associated with falls and osteoporosis; and colon cancer was associated with depression and osteoporosis. ConclusionElderly patients with cancer experience a higher prevalence of geriatric syndromes than those without cancer. Prospective studies that establish the causal relationships between cancer and geriatric syndromes are necessary.

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Section: Introductionmentioning

confidence: 99%

Association of Cancer With Geriatric Syndromes in Older Medicare Beneficiaries

Mohile

Fan

Reeve

et al. 2011

JCO

197

112

View full text Add to dashboard Cite

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“…[9][10][11] Disability and comorbidity have distinct and possibly synergistic influences on underlying vulnerability and frailty in the elderly. Disability, or functional impairment, is defined as dependency in performing tasks that allow for self care and living in the community and also may include difficulties with physical mobility.…”

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confidence: 99%

A pilot study of the vulnerable elders survey‐13 compared with the comprehensive geriatric assessment for identifying disability in older patients with prostate cancer who receive androgen ablation

Mohile

Bylow

Dale

et al. 2007

Cancer

241

156

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BACKGROUND.Impairments in geriatric domains adversely affect health outcomes of the elderly. The Comprehensive Geriatric Assessment (CGA) is a key component of the treatment approach for older cancer patients, but it is time consuming. In this pilot study, the authors evaluated the validity of a brief, functionally based screening tool, the Vulnerable Elders Survey‐13 (VES‐13), for identifying older patients with prostate cancer (PCa) with impairment in the oncology clinic setting.METHODS.Patients with PCa aged ≥70 years who actively were receiving androgen ablation treatment and who were followed within the clinics at the University of Chicago were eligible. Patients self‐completed the VES‐13 and CGA instruments and repeated the VES‐13 1 month later. Physical performance and cognitive assessments were administered by a research assistant.RESULTS.Of 50 participating patients, 50% were identified as impaired by the VES‐13 (score ≥3). Sixty percent of patients scored as impaired on ≥2 tests within the CGA, exhibiting deficits in multiple domains. The reliability of the VES‐13 (Pearson correlation coefficient) was 0.92. The cut‐off score of 3 on the VES‐13 had 72.7% sensitivity and 85.7% specificity for CGA deficits and was highly predictive for identifying impairment (area under the receiver operating characteristic curve, 0.90). Patients who had mean VES‐13 scores ≥3 performed significantly worse on evaluations of activities of daily living (P = .001), physical performance (P = .002), comorbidity (P = .004), and cognitive impairment (P = .003).CONCLUSIONS.Functional and cognitive impairments are highly prevalent among older patients with PCa who receive androgen ablation in oncology clinics. The current results indicated that the brief VES‐13 performed nearly as well as a conventional CGA in detecting geriatric impairment in this population. Cancer 2007. © 2007 American Cancer Society.

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“…and the tumor location (lung, breast). Most cancers in elderly individuals have high level of progress (9). Though there is a high prevalence of cancer, it should be noted that cancer is a disease caused by the involvement of different factors.…”

Section: Original Articlementioning

confidence: 99%

Knowledge and socio-demographic factors about colorectal cancer screening: cross sectional analysis the west of Iran

Alavijeh

Mahbobi

Jalilian

2016

Arvand Journal of Health and Medical Sciences

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Cancer is the second leading cause of death in developed countries and the third one in developing countries. The aim of this study was to determine the knowledge on colorectal cancer and the related background factors in the urban population aged over 50 years in the western of Iran. This study was of descriptive cross-sectional type which was conducted among 500 individuals aged over 50 years in city Ravansar were randomly selected to participate voluntarily in the study. Data collected by questioner and were analyzed by SPSS version 21 using independent t-test, ANOVA and correlation statistical tests at 95% significant level. The mean age of respondents was 58.32 years [95% CI: 57.7, 58.9], ranged from 50 to 73 years. Only 4.7 percent of the participants knew what colorectal cancer was and what its screening methods were. The mean score of knowledge construct about colorectal cancer among the participants was 5.72 with standard deviation of ±2.57. Furthermore, knowledge of cervical cancer was significant association with sex, educational level and positive family history of colorectal cancer. In addition, knowledge about colorectal cancer was significantly related to the age (r= -0. 095 & P=0.040). Based on our result, it seems that designing and implementation of educational programs to improve knowledge about colorectal cancer among population is necessary.

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Epidemiology of Cancer and Aging

Cited by 59 publications

References 44 publications

Association of Cancer With Geriatric Syndromes in Older Medicare Beneficiaries

Association of Cancer With Geriatric Syndromes in Older Medicare Beneficiaries

A pilot study of the vulnerable elders survey‐13 compared with the comprehensive geriatric assessment for identifying disability in older patients with prostate cancer who receive androgen ablation

Knowledge and socio-demographic factors about colorectal cancer screening: cross sectional analysis the west of Iran

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