Tumor Volume as a Prognostic Factor in Oropharyngeal Squamous Cell Carcinoma Treated With Primary Radiotherapy

Been, Mark J.; Watkins, Joanna Alexandra; Manz, Ryan; Gentry, Lindell R.; Leverson, Glen; Harari, Paul M.; Hartig, Gregory K.

doi:10.1097/mlg.0b013e318172c82c

Cited by 33 publications

(28 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Been et al . (12) showed no significant correlation of tumor volume with LRC ( p = 0.6244). Mendenhall et al .…”

Section: Discussionmentioning

confidence: 90%

“…Several earlier studies using primarily two-dimensional (2D) treatments modalities have observed no significant correlation between tumor volume and locoregional control (4, 10–12). In contrast, one 3D-CRT study (13) and two IMRT studies have shown that tumor volume is predictive of locoregional control but are limited by sample size or a large number of postoperative patients (14, 15).…”

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Intensity-Modulated Radiation Therapy in Oropharyngeal Carcinoma: Effect of Tumor Volume on Clinical Outcomes

Lok

Setton

Caria

et al. 2012

International Journal of Radiation Oncology*Biology*Physics

View full text Add to dashboard Cite

Purpose To analyze the effect of primary gross tumor volume (pGTV) and nodal gross tumor volume (nGTV) on treatment outcomes in patients treated with definitive intensity-modulated radiation therapy (IMRT) for oropharyngeal cancer (OPC). Methods and Materials Between September 1998 and April 2009, a total of 442 patients with squamous cell carcinoma of the oropharynx were treated with IMRT with curative intent at our center. Thirty patients treated post-operatively and 2 additional patients who started treatment more than 6 months after diagnosis were excluded. A total of 340 patients with restorable treatment plans were included in this present study. The majority of the patients underwent concurrent platinum-based chemotherapy. The pGTV and nGTV were calculated using the original clinical treatment plans. Cox proportional hazards models and log-rank tests were used to evaluate the correlation between tumor volumes and overall survival (OS), and competing risks analysis tools were used to evaluate the correlation between local failure (LF), regional failure (RF), distant metastatic failure (DMF) vs. tumor volumes with death as a competing risk. Results Median follow-up among surviving patients was 34 months (range, 5-67). The 2-year cumulative incidence of LF, RF and DF in this cohort of patients was 6.1%, 5.2%, and 12.2%, respectively. The 2-year OS rate was 88.6%. Univariate analysis determined pGTV and T-stage correlated with LF (p < 0.0001 and p = 0.004, respectively), whereas nGTV was not associated with RF. On multivariate analysis, pGTV and N-stage were independent risk factors for overall survival (p = 0.0003 and p = 0.0073, respectively) and distant control (p = 0.0008 and p = 0.002, respectively). Conclusions In this cohort of patients with OPC treated with IMRT, pGTV was found to be associated with overall survival, local failure, and distant metastatic failure.

show abstract

“…Been et al . (12) showed no significant correlation of tumor volume with LRC ( p = 0.6244). Mendenhall et al .…”

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 97%

Intensity-Modulated Radiation Therapy in Oropharyngeal Carcinoma: Effect of Tumor Volume on Clinical Outcomes

Lok

Setton

Caria

et al. 2012

International Journal of Radiation Oncology*Biology*Physics

View full text Add to dashboard Cite

show abstract

“…Tumor burden is a known predictor of the response to definitive RT (28,29). The T stage represents the primary tumor burden; however, it is not a statistically significant prognostic factor for the PFS.…”

Section: Discussionmentioning

confidence: 99%

Primary Tumor Site as a Predictor of Treatment Outcome for Definitive Radiotherapy of Advanced-Stage Oral Cavity Cancers

Lin

Wang

Kang

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

View full text Add to dashboard Cite

“…Some studies have indicated that the volume of the primary tumor correlates with treatment outcome in patients with advanced HNSCC with the exception of oropharyngeal tumors. 40,41 However, it is unclear whether nodal volume predicts survival in patients with head and neck cancers. While some studies suggested deteriorating regional control 42,43 and worse disease-specific survival 44 in patients with large nodes, other studies did not find any relationship between nodal volume and disease-specific survival.…”

Section: Discussionmentioning

confidence: 99%

Prediction of Disease-Free Survival in Patients with Squamous Cell Carcinomas of the Head and Neck Using Dynamic Contrast-Enhanced MR Imaging

Chawla¹,

Kim²,

Loevner³

et al. 2011

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

Tumor Volume as a Prognostic Factor in Oropharyngeal Squamous Cell Carcinoma Treated With Primary Radiotherapy

Abstract: Tumor volume does not appear to play a significant role in predicting locoregional recurrence for patients with primary squamous cell cancer of the oropharynx treated with primary radiotherapy. However, T4 status was predictive of poor locoregional control.

Cited by 33 publications

References 19 publications

Intensity-Modulated Radiation Therapy in Oropharyngeal Carcinoma: Effect of Tumor Volume on Clinical Outcomes

Intensity-Modulated Radiation Therapy in Oropharyngeal Carcinoma: Effect of Tumor Volume on Clinical Outcomes

Primary Tumor Site as a Predictor of Treatment Outcome for Definitive Radiotherapy of Advanced-Stage Oral Cavity Cancers

Prediction of Disease-Free Survival in Patients with Squamous Cell Carcinomas of the Head and Neck Using Dynamic Contrast-Enhanced MR Imaging

Contact Info

Product

Resources

About