Primary Tumor Site as a Predictor of Treatment Outcome for Definitive Radiotherapy of Advanced-Stage Oral Cavity Cancers

Lin, Chien‐Yu; Wang, Hung‐Ming; Kang, Chung‐Jan; Lee, Li‐Yu; Huang, Shyh‐Chin; Fan, Kang‐Hsing; Chen, Eric Yen-Chao; Chen, I-How; Liao, Chun-Ta; Chang, Joseph Tung-Chieh

doi:10.1016/j.ijrobp.2009.09.074

Cited by 42 publications

(30 citation statements)

References 32 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 2011, Boldrup et al emphasized the importance of differentiating the anatomical subsites as well as the histological mucosa conditions to sufficiently evaluate the histomorphological patterns of head and neck cancer [8]. Furthermore, the outcome of radiation therapy in advanced disease has been suggested to be associated with the anatomic location of the tumour [6]. …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Site-specific gene expression patterns in oral cancer

et al. 2017

View full text Add to dashboard Cite

BackgroundSquamous cell carcinomas (SCCs) are the most prevalent malignant tumours within the head and neck. Evidence exists that distinct genes are differentially regulated in SCCs of the oral cavity compared to other head and neck regions. Given this background, the aim of this study was to investigate whether such tumour site-specific gene expression can also be observed in different localizations within the oral cavity.MethodsUsing tissue microarrays (TMAs), we investigated 76 SCCs of the floor of the mouth, 49 SCCs of the tongue and 68 SCCs of other anatomic regions within the oral cavity. The expression of 17 genes involved in cell cycle and growth control (p16, p21, p27, p53, cyclin D1, EGFR, c-kit, bcl-6), cell adhesion (alpha-, beta-, and gamma-catenin), and apoptosis/stress response genes (Hif-1-alpha, Glut 1, CA IX, caspase, hsp70, XIAP) were investigated by means of immunohistochemistry. The data were subjected to chi2, interdependency and Kaplan-Meier analysis.ResultsOur study suggests a remote difference in the site-specific gene expression patterns of oral cancer. X-linked inhibitor of apoptosis (XIAP) showed a significantly higher expression (p <0.05) in SCCs of the floor of the mouth compared to SCCs of the tongue and other locations within the oral cavity. The increased XIAP expression was further associated with significantly decreased overall survival in all cases of SCCs of the oral cavity (p <0.05). Expression levels of p53, CA IX, beta-catenin, Hif-1-alpha, and c-kit were also observed to be inversely related between SCCs of the floor of the mouth and those of the tongue respectively, although these differences did not reach statistical significance. Overall and event-free survival did not differ in patients with T1/T2/N0 SCCs according to tumour localization.ConclusionIn summary, the protein expression patterns of SCCs of the oral cavity suggest the existence of a molecular and morphological spectrum of SCCs in the oral cavity. In particular the expression pattern of XIAP indicates distinct gene expression patterns between carcinomas of the floor of the mouth and oral tongue cancer. Further studies are needed to identify possible tumour site-specific factors that influence patient prognosis and management.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Several studies have reported specific metastatic pathways according to tumour localization and different responses to radiation therapy depending on the anatomical site [4–6]. Belbin et al showed that specific biological mechanisms underlying tumour aggressiveness are heavily influenced by the site of the primary tumour [7].…”

Section: Introductionmentioning

confidence: 99%

Site-specific gene expression patterns in oral cancer

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Different subsites of oral cavity cancers, although grouped together, have different natural history and treatment outcomes. The reported incidence of lymph node metastasis in bucco‐alveolar complex lesions is approximately 25%‐30%, whereas in tongue and floor of mouth cancers it ranges up to 75% . In addition, the predictive factors for nodal metastasis are different for the 2 subsites.…”

Section: Discussionmentioning

confidence: 99%

Significance of perineural invasion in locally advanced bucco alveolar complex carcinomas treated with surgery and postoperative radiation ± concurrent chemotherapy

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The radiation field included the entire tumor bed area (with 1‐ to 2‐cm margins) as well as the regional lymphatics. Concomitant chemoradiotherapy (CRT; 66 Gy) with cisplatin‐based regimens was administered to patients with extracapsular spread (ECS), multiple lymph node metastases, positive margins, or ≥3 minor risk factors (ie, the above‐mentioned minor risk factors plus pT4) . The chemotherapy regimen consisted of intravenous cisplatin 50 mg/m 2 biweekly plus daily oral tegafur 800 mg and leucovorin 60 mg, cisplatin 40 mg/m 2 weekly, or cisplatin 100 mg/m 2 every 3 weeks …”

Section: Methodsmentioning

confidence: 99%