Tumor-targeting nanogel that can function independently for both photodynamic and photothermal therapy and its synergy from the procedure of PDT followed by PTT

Kim, Jayoung; Choi, Won Il; Kim, Manse; Tae, Giyoong

doi:10.1016/j.jconrel.2013.07.006

Cited by 138 publications

(86 citation statements)

References 36 publications

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“…This interaction is small in Type-II process, or when Type-I is minor, then we may have solved for PTT independently to PDT. The data shown by Kim et al, [20] implies that conducting PDT prior to PTT caused small or minimum depletion of C(z,t), such that it does not affect the A and B constant in Eq. (1) in solving the temperature increase.…”

Section: Discussion Of Combined Ptt and Pdtmentioning

confidence: 96%

“…The animal study of Kim et al, [20] showed that tumor-targeting nanogel can function independently for both PDT and PTT and its synergy from the procedure of PDT followed by PTT, which is more effective than PTT followed by PDT due to certain interference from PTT, if it was applied to the system prior to PDT. As described earlier that A(z,t) and B(z,t) are decreasing function of time, when PS concentration, C(z,t), is depleted in time.…”

Section: Discussion Of Combined Ptt and Pdtmentioning

confidence: 99%

“…NPs for dual-modality of fluorescence and magnetic resonance imaging-guided, and dual-therapy using photothermal therapy (PTT) and photodynamic therapy (PDT) have been developed recently [11][12][13][14][15][16][17][18][19][20][21][22], where synergic treatment modalities combining PDT with PTT could overcome current limitations of PDT, thus achieving enhanced anticancer efficacy.…”

Section: Introductionmentioning

confidence: 99%

“…The animal study of Kim et al, [20] showed that tumor-targeting nanogel can function independently for both PDT and PTT and its synergy from the procedure of PDT followed by PTT, which is more effective than PTT followed by PDT. In addition to a review of clinical studies, we will propose modeling systems to analyze the synergic feature and explore the roles of key parameters influencing the anticancer efficacy.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Progress of nanotechnology for phototherapy: Fundamentals and applications

Lin¹,

Chen²,

Liu³

2017

Med Devices Diagn Eng

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Section: Discussion Of Combined Ptt and Pdtmentioning

confidence: 96%

Section: Discussion Of Combined Ptt and Pdtmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The animal study of Kim et al, [20] showed that tumor-targeting nanogel can function independently for both PDT and PTT and its synergy from the procedure of PDT followed by PTT, which is more effective than PTT followed by PDT. In addition to a review of clinical studies, we will propose modeling systems to analyze the synergic feature and explore the roles of key parameters influencing the anticancer efficacy.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Progress of nanotechnology for phototherapy: Fundamentals and applications

Lin¹,

Chen²,

Liu³

2017

Med Devices Diagn Eng

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“…TiO 2 has many attractive properties such as biocompatibility, chemical stability and photocatalytic activity. It is these properties especially its photocatalytic activity that make it an attractive species for use in photothermal therapy [114,173,[220][221][222][223]. Figure 4 shows a schematic of the photocatalytic process for TiO 2 .…”

Section: Photoablation Therapy: Photodynamic and Photothermal Therapymentioning

confidence: 99%

Nanoparticles in biomedical applications

McNamara

Tofail

2016

Advances in Physics: X

277

253

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Engineering of Multifunctional Nano‐Micelles for Combined Photothermal and Photodynamic Therapy Under the Guidance of Multimodal Imaging

Gong

Dong

Liu

et al. 2014

Adv Funct Materials

248

154

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The integration of diagnostic and therapeutic functionalities on a single theranostic nano‐system holds great promise to enhance the accuracy of diagnosis and improve the efficacy of therapy. Herein, a multifunctional polymeric nano‐micelle system that contains a photosensitizer chlorin e6 (Ce6) is successfully fabricated, at the same time serving as a chelating agent for Gd3+, together with a near‐infrared (NIR) dye, IR825. With a r1 relativity 7 times higher than that of the commercial agent Magnevist, strong fluorescence offered by Ce6, and high NIR absorbance attributed to IR825, these theranostic micelles can be utilized as a contrast agent for triple modal magnetic resonance (MR), fluorescence, and photoacoustic imaging of tumors in a mouse model. The combined photothermal and photodynamic therapy is then carried out, achieving a synergistic anti‐tumor effect both in vitro and in vivo. Different from single photo treatment modalities which only affect the superficial region of the tumor under mild doses, the combination therapy at the same dose using this agent is able to induce significant damage to both superficial and deep parts of the tumor. Therefore, this work presents a polymer based theranostic platform with great potential in multimodal imaging and combination therapy of cancer.

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Tumor-targeting nanogel that can function independently for both photodynamic and photothermal therapy and its synergy from the procedure of PDT followed by PTT

Cited by 138 publications

References 36 publications

Progress of nanotechnology for phototherapy: Fundamentals and applications

Progress of nanotechnology for phototherapy: Fundamentals and applications

Nanoparticles in biomedical applications

Engineering of Multifunctional Nano‐Micelles for Combined Photothermal and Photodynamic Therapy Under the Guidance of Multimodal Imaging

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