Tumor-targeted small molecule for dual-modal imaging-guided phototherapy upon near-infrared excitation

Meng, Xianghe; Li, Wenjun; Sun, Zhihong; Zhang, Jiali; Deng, Guanjun; Gong, Ping; Cai, Lintao

doi:10.1039/c7tb02496g

Cited by 38 publications

(33 citation statements)

References 22 publications

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“…Among the photothermal agents, NIR organic dyes also show strong potential in noninvasive tumor therapy, and indocyanine green as an NIR-heptamethine cyanine dye has been used in clinical diagnosis. 9 , 10 This dye preferentially accumulates in tumor cells, yielding a good signal-to-background ratio. 9 As reported by Jain et al, AuNPs of 40 nm size show an absorption cross section that is 5 orders higher than conventional absorbing dyes, 11 making plasmonic NPs ideal photothermal agents, with much higher efficiency than the more commonly used organic dyes.…”

Section: Introductionmentioning

confidence: 99%

“… 9 , 10 This dye preferentially accumulates in tumor cells, yielding a good signal-to-background ratio. 9 As reported by Jain et al, AuNPs of 40 nm size show an absorption cross section that is 5 orders higher than conventional absorbing dyes, 11 making plasmonic NPs ideal photothermal agents, with much higher efficiency than the more commonly used organic dyes. Therefore, metallic NPs offer enhanced absorption and scattering in the NIR region, facile synthesis, and good biocompatibility, as compared to organic dyes.…”

Section: Introductionmentioning

confidence: 99%

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Photothermal Cellulose-Patch with Gold-Spiked Silica Microrods Based on Escherichia coli

Han

Hong

et al. 2018

ACS Omega

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Plasmonic-mediated photothermal heating under near-infrared (NIR) irradiation is an emerging key technology in the field of photothermal therapy and chemical reactions. However, there are few reports of photothermal film (dry-type patch), and thus, in this work, we developed the plasmonic-induced photothermal cellulose-patch operating in the NIR region. Hollow and spikelike gold nanostructures, gold-spikes, as plasmonic nanoparticles were prepared and decorated on silica microrods, which were prepared based on a unicellular organism, Escherichia coli, as a framework. In addition, freestanding cellulose-patch was prepared by mixing filter-paper pulp and armored golden E. coli (AGE) microrods. The major absorbing peak of AGE solution was revealed to be 873 nm, and the surface temperature of patch was increased to 264 °C within a very short time (1 min). When NIR laser was irradiated on the patch dipped in the water, the formation of water vapor and air bubbles was observed. The heating efficiency of indirect heat transfer via conduction from patch-to-water was 35.0%, while that of direct heat transfer via radiation from patch in water was 86.1%. Therefore, the cellulose-patch containing AGE microrods has possible applicability to desalination and sterilization because of its fast heating rate and high light-to-heat conversion under the irradiation of low-powered IR laser.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Photothermal Cellulose-Patch with Gold-Spiked Silica Microrods Based on Escherichia coli

Han

Hong

et al. 2018

ACS Omega

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“…Fang et al [21] used IR-822 as a fluorescent group because of its excellent tumor preferential aggregation and other characteristics. IR-822 was conjugated to N1-(pyridine-4-methyl) ethane-1,2-diamine (PY), a pH sensing receptor, to form a fluorescent spacer receptor molecular probe 3 ( Fig.…”

Section: Application Of Ph-sensitive Nir Fluorescence Probesmentioning

confidence: 99%

Research progress of near-infrared fluorescence probes based on indole heptamethine cyanine dyes in vivo and in vitro

Sun

Wang

et al. 2020

BMC Chemistry

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Near-infrared (NIR) fluorescence imaging is a noninvasive technique that provides numerous advantages for the realtime in vivo monitoring of biological information in living subjects without the use of ionizing radiation. Near-infrared fluorescent (NIRF) dyes are widely used as fluorescent imaging probes. These fluorescent dyes remarkably decrease the interference caused by the self-absorption of substances and autofluorescence, increase detection selectivity and sensitivity, and reduce damage to the human body. Thus, they are beneficial for bioassays. Indole heptamethine cyanine dyes are widely investigated in the field of near-infrared fluorescence imaging. They are mainly composed of indole heterocyclics, heptamethine chains, and N-substituent side chains. With indole heptamethine cyanine dyes as the parent, introducing reactive groups to the parent compounds or changing their structures can make fluorescent probes have different functions like labeling protein and tumor, detecting intracellular metal cations, which has become the hotspot in the field of fluorescence imaging of biological research. Therefore, this study reviewed the applications of indole heptamethine cyanine fluorescent probes to metal cation detection, pH, molecules, tumor imaging, and protein in vivo. The distribution, imaging results, and metabolism of the probes in vivo and in vitro were described. The biological application trends and existing problems of fluorescent probes were discussed.

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“…Moreover, recently NIR fluorophore-based therapeutic methods such as photodynamic therapy (PDT) and photothermal therapy (PTT) have attracted considerable attention, because the fluorophores could serve not only as a visualizing module but also a drug which will be activated under light irradiation to release reactive species, such as cytotoxic reactive oxygen species ( • OH, 1 O 2 , O 2 •- ) [ 39 , 40 ]. Cai and co-workers [ 41 ] reported a heptamethine cynanine dye IR-822 conjugated with N 1 -(pyridin-4-ylmethyl)ethane-1,2-diamine as a pH-sensing receptor 7 ( Fig. 3 F).…”

Section: Non-cleavable Conjugatesmentioning

confidence: 99%

Recent advances in construction of small molecule-based fluorophore-drug conjugates

Lang

Yuan

Zhu

et al. 2020

Journal of Pharmaceutical Analysis

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As a powerful tool to advance drug discovery, molecular imaging may provide new insights into the process of drug effect and therapy at cellular and molecular levels. When compared with other detection methods, fluorescence-based strategies are highly attractive and can be used to illuminate pathways of drugs’ transport, with multi-color capacity, high specificity and good sensitivity. The conjugates of fluorescent molecules and therapeutic agents create exciting avenues for real-time monitoring of drug delivery and distribution, both in vitro and in vivo. In this short review, we discuss recent developments of small molecule-based fluorophore-drug conjugates, including non-cleavable and cleavable ones, that are capable of visualizing drug delivery.

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Tumor-targeted small molecule for dual-modal imaging-guided phototherapy upon near-infrared excitation

Abstract: A tumor-targeted small molecule for dual-modal imaging-guided phototherapy upon near-infrared excitation.

Cited by 38 publications

References 22 publications

Photothermal Cellulose-Patch with Gold-Spiked Silica Microrods Based on Escherichia coli

Photothermal Cellulose-Patch with Gold-Spiked Silica Microrods Based on Escherichia coli

Research progress of near-infrared fluorescence probes based on indole heptamethine cyanine dyes in vivo and in vitro

Recent advances in construction of small molecule-based fluorophore-drug conjugates

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