Tumor Shrinkage Assessed by Volumetric MRI in the Long-Term Follow-Up after Stereotactic Radiotherapy of Meningiomas

Astner, Sabrina T.; Theodorou, Marilena; Dobrei-Ciuchendea, Mihaela; Auer, Florian; Kopp, Claire B.; Molls, M.; Grosu, Anca‐Ligia

doi:10.1007/s00066-010-2138-x

Cited by 39 publications

(36 citation statements)

References 25 publications

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“…Both groups showed TV shrinkage at the follow-up examinations: the size of the residual volumes were 89.6 ± 19.9% and 81.7 ± 6.6% for inoperable and 83.9 ± 21.6% and 75.0 ± 19.1% for operated patients at one-and two-year follow-up, respectively. These findings correspond with Astner et al [16] and Henzel et al [17] who also could not find any predictive correlation between TV shrinkage after RT and operability.…”

Section: Discussionsupporting

confidence: 80%

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Volumetric response of intracranial meningioma after photon or particle irradiation

et al. 2016

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Background: Meningiomas are usually slow growing, well circumscribed intracranial tumors. In symptom-free cases observation with close follow-up imaging could be performed. Symptomatic meningiomas could be surgically removed and/or treated with radiotherapy. The study aimed to evaluate the volumetric response of intracranial meningiomas at different time points after photon, proton, and a mixed photon and carbon ion boost irradiation. Patients and methods: In Group A 38 patients received proton therapy (median dose: 56 GyE in 1.8-2 GyE daily fractions) or a mixed photon/carbon ion therapy (50 Gy in 2 Gy daily fractions with intensity modulated radiotherapy (IMRT) and 18 GyE in 3 GyE daily dose carbon ion boost). Thirty-nine patients (Group B) were treated by photon therapy with IMRT or fractionated stereotactic radiotherapy technique (median dose: 56 Gy in 1.8-2 Gy daily fractions). The delineation of the tumor volume was based on the initial, one-and two-year follow-up magnetic resonance imaging and these volumes were compared to evaluate the volumetric tumor response. Results: Significant tumor volume shrinkage was detected at one-and at two-year follow-up both after irradiation by particles and by photons. No significant difference in tumor volume change was observed between photon, proton or combined photon plus carbon ion boost treated patients. WHO grade and gender appear to be determining factors for tumor volume shrinkage. Conclusion: Significant volumetric shrinkage of meningiomas could be observed independently of the applied radiation modality. Long-term follow-up is recommended to evaluate further dynamic of size reduction and its correlation with outcome data.

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Section: Discussionsupporting

confidence: 80%

“…Astner et al [16] described TV shrinkage by evaluating the initial and follow-up volumetric data of irradiated meningiomas. They measured the TVs of 53 FSRT and six SRT-treated patients.…”

Section: Discussionmentioning

confidence: 99%

Volumetric response of intracranial meningioma after photon or particle irradiation

et al. 2016

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“…The outcome after treatment (surgery and/or irradiation) of SMN meningioma was favorable in 4 of 5 patients of our cohort, as radiotherapy is an effective treatment [1].…”

Section: Schlüsselwörtermentioning

confidence: 94%

“…1 Patients characteristics for PMN and SMN and outcome in 5 patients with meningioma as SMN after oncological treatment during childhood …”

mentioning

confidence: 99%

Meningioma as second malignant neoplasm after oncological treatment during childhood

et al. 2012

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A total of 38 patients (18 female/20 male) with childhood meningioma were recruited from the German registry HIT-Endo (1989-2009). In 5 cases meningioma occurred as second malignant neoplasm (SMN). Histologies were confirmed by reference assessment in all cases (SMN: 2 WHO I, 1 WHO II, 2 WHO III). The SMNs were diagnosed at a median age of 12.4 years with a median latency of 10.2 years after primary malignancy (PMN; 4 brain tumors, 1 lymphoblastic leukemia; median age at diagnosis 2.7 years). Meningioma occurred as SMN in the irradiated field of PMN (range 12-54 Gy). The outcome after treatment of SMN meningioma (surgery/irradiation) was favorable in terms of psychosocial status and functional capacity in 4 of 5 patients (1 death). We conclude that survivors of childhood cancer who were exposed to radiation therapy at young age harbor the risk of developing meningioma as a SMN at a particularly short latency period in case of high dose exposure.

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“…Stereotactic radiotherapy is an upcoming method for curative treatment [13,14,15]. However, stereotactic body radiotherapy (SBRT) needs a precise target volume definition to deliver a high dose to the tumor, while sparing surrounding tissue.…”

mentioning

confidence: 99%

Respiratory gated [18F]FDG PET/CT for target volume delineation in stereotactic radiation treatment of liver metastases

et al. 2012

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Tumor Shrinkage Assessed by Volumetric MRI in the Long-Term Follow-Up after Stereotactic Radiotherapy of Meningiomas

Cited by 39 publications

References 25 publications

Volumetric response of intracranial meningioma after photon or particle irradiation

Volumetric response of intracranial meningioma after photon or particle irradiation

Meningioma as second malignant neoplasm after oncological treatment during childhood

Respiratory gated [18F]FDG PET/CT for target volume delineation in stereotactic radiation treatment of liver metastases

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