Tumor-related factors and patient’s age influence survival after resection for ampullary adenocarcinoma

Barauskas, Giedrius; Gulbinas, Antanas; Pranys, Darius; Dambrauskas, Žilvinas; Pundzius, Juozas

doi:10.1007/s00534-007-1313-7

Cited by 26 publications

(17 citation statements)

References 24 publications

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“…30,34 In fact, the presence of lymph node metastasis was associated with a median survival less than one-third that of patients without nodal metastasis (Fig. 3).…”

Section: Discussionmentioning

confidence: 94%

“…Our findings are consistent with data from smaller series that have noted an incidence of lymph node metastasis of 20% to 25% for patients with T1-T2 disease. 30 In aggregate, these data strongly suggest that even patients with early invasive adenocarcinoma of the ampulla have a high risk of lymph node metastasis and are best served with an operation that includes lymph node dissection and clearance.…”

Section: Discussionmentioning

confidence: 97%

“…6,29 Because of the relative scarcity of the disease, data on the surgical management of neoplasms of the ampulla of Vater have been lacking. Most studies suffer from small sample size 28,30,31 or provide aggregate data on "peri-ampullary" Figure 2 Overall survival for patients undergoing resection of an ampullary adenoma was no different than age-matched populationbased controls. Patients who underwent resection of an adenocarcinoma had a significantly worse long-term survival (P<0.001).…”

Section: Discussionmentioning

confidence: 98%

See 2 more Smart Citations

Clinicopathologic Analysis of Ampullary Neoplasms in 450 Patients: Implications for Surgical Strategy and Long-Term Prognosis

Winter

Cameron

Olino

et al. 2010

Journal of Gastrointestinal Surgery

188

139

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“…30,34 In fact, the presence of lymph node metastasis was associated with a median survival less than one-third that of patients without nodal metastasis (Fig. 3).…”

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Clinicopathologic Analysis of Ampullary Neoplasms in 450 Patients: Implications for Surgical Strategy and Long-Term Prognosis

Winter

Cameron

Olino

et al. 2010

Journal of Gastrointestinal Surgery

188

139

View full text Add to dashboard Cite

show abstract

“…Ampullary carcinoma is an aggressive disease; however, it is characterized by satisfactory overall survival [7,11,12] . The current study presents a median survival rate of 109.1 months, corresponding to the data from other high volume centres [9,13] .…”

Section: Discussionmentioning

confidence: 99%

“…The standard surgical procedure was a pancreatoduodenectomy with an end-to-side pancreaticojejunostomy as defined by our group earlier [11] .…”

Section: Methodsmentioning

confidence: 99%

Preoperative Endoscopic Biliary Drainage May Negatively Impact Survival Following Pancreatoduodenectomy for Ampullary Cancer

Barauskas

Urbonas²,

Smailytė³

et al. 2016

Dig Surg

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Background/Aims: Ampullary carcinoma is a rare tumour with a high resectability rate. There is an increasing body of evidence indicating not only tumour-related factors, but also jaundice influence survival following curative resection. Several modalities for preoperative biliary drainage are available; however, routine preoperative endoscopic biliary drainage (PEBD) is not recommended. There is no sufficient data regarding the impact of PEBD on long-term outcomes. The aim of our study was to identify predictive factors of survival with special regard to PEBD in patients undergoing curative resection for ampullary carcinoma. Patients and Methods: Data from 64 consecutive patients with adenocarcinoma of the papilla of Vater who have been operated on was analysed. Overall survival was defined from the date of surgery to the date of death, or censored at the last patient contact. Survival analysis was determined by means of the Kaplan-Meier method. The significance of the demographic, clinical and histopathologic factors was ascertained by the log-rank test. A Cox proportional hazard model was used to determine independent prognostic factors of survival. Results: Twenty patients (31.2%) underwent PEBD. Univariate analysis revealed tumour-related factors, age over 70, and PEBD to negatively influence survival. Five of them (excluding T stage) were identified as the independent prognosticators, while PEBD appeared to be the most decisive factor. Median survival for patients who underwent PEBD was 25.3 months as compared to 112.9 months for those who did not. In conclusion, PEBD negatively affected long-term outcomes in our patients with resected ampullary carcinoma.

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Clinical significance of pathologic subtype in curatively resected ampulla of vater cancer

Kim

Choi

et al. 2011

Journal of Surgical Oncology

109

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An advanced T stage, nodal metastasis, poor differentiation, and the pancreaticobiliary type were found to be independent predictors of recurrence after curative resection of ampullary carcinoma by multivariate analysis. In addition, the pancreatobiliary type tended to present in a more advanced T stage and more frequently with regional lymph node involvement and perineural invasion than the intestinal type. Furthermore, CEA level and lymph node metastasis were found to be independent predictors of recurrence for the intestinal and pancreatobiliary types, respectively.

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Tumor-related factors and patient’s age influence survival after resection for ampullary adenocarcinoma

Abstract: Pancreatoduodenectomy for ampullary carcinoma is reasonable in terms of postoperative morbidity and mortality. Tumor-related factors, R0 resection, and advanced age appeared as the main predictors of survival.

Cited by 26 publications

References 24 publications

Clinicopathologic Analysis of Ampullary Neoplasms in 450 Patients: Implications for Surgical Strategy and Long-Term Prognosis

Clinicopathologic Analysis of Ampullary Neoplasms in 450 Patients: Implications for Surgical Strategy and Long-Term Prognosis

Preoperative Endoscopic Biliary Drainage May Negatively Impact Survival Following Pancreatoduodenectomy for Ampullary Cancer

Clinical significance of pathologic subtype in curatively resected ampulla of vater cancer

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