Tumor programmed cell death ligand 1 expression correlates with nodal metastasis in patients with cutaneous squamous cell carcinoma of the head and neck

García-Pedrero, Juana M.; Martínez–Camblor, Pablo; Díaz-Coto, Susana; Munguía-Calzada, Pablo; Vallina-Álvarez, Aitana; Vázquez‐López, Francisco; Rodrigo, Juan P.; Santos‐Juanes, Jorge

doi:10.1016/j.jaad.2017.05.047

Cited by 48 publications

(33 citation statements)

References 32 publications

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“…Two studies have reported that positive proportion scores of PD-L1 expression in TCs were correlated with the risk of lymph node metastasis. 15,17 In contrast, another report suggested that PD-L1 expression in TCs was not associated with lymph node metastasis. 16 These three studies have analyzed PD-L1 expression by proportion, but not by intensity score.…”

Section: Discussionmentioning

confidence: 95%

“…Previous studies showed inconsistent results of the relationship between the proportion of PD‐L1‐positive cells and prognosis in cSCC. Two studies have reported that positive proportion scores of PD‐L1 expression in TCs were correlated with the risk of lymph node metastasis . In contrast, another report suggested that PD‐L1 expression in TCs was not associated with lymph node metastasis .…”

Section: Discussionmentioning

confidence: 99%

“…There have been similar immunohistochemical studies examining PD‐L1 expression in cSCC . However, the correlation between the PD‐L1 expression in primary lesions and the incidence of metastasis is still unclear.…”

Section: Introductionmentioning

confidence: 99%

“…14 There have been similar immunohistochemical studies examining PD-L1 expression in cSCC. [15][16][17] However, the correlation between the PD-L1 expression in primary lesions and the incidence of metastasis is still unclear. In the present study, we studied this potential relationship between PD-L1 expression and clinical outcomes in cSCC cases.…”

Section: Introductionmentioning

confidence: 99%

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Association between PD‐L1 expression and lymph node metastasis in cutaneous squamous cell carcinoma

Kamiya

Kato

Kamiya

et al. 2018

Asia-Pac J Clncl Oncology

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Aim To clarify the relationship between programmed cell death ligand 1 (PD‐L1) expression in cutaneous squamous cell carcinoma (cSCC) and clinicopathological variables. Methods We examined PD‐L1 expression in tumor cells (TCs) and tumor infiltrating immune cells (ICs) in 46 cases of cSCC by immunohistochemistry. In each case, we employed two methods—intensity and proportion scores—to evaluate PD‐L1 expression in TCs. For the evaluation of PD‐L1 expression in ICs, only the proportion score was used. Association between PD‐L1 expression and clinicopathological variables was analyzed using Fisher's exact test. Results High intensity scores in TCs were observed in 18 of the 46 cases (39.1%) and low intensity scores were observed in 28 cases (60.9%). Applying the proportions, using cut‐off values of ≥1% and 50%, positive scores in TCs were observed in 36 (78.3%) and 20 cases (43.5%), respectively. PD‐L1‐positive ICs were observed in 29 (63%) and seven cases (15.2%), using cut‐off values of ≥1% and 10%, respectively. The high intensity scores in TCs correlated with lymph node metastasis (P = 0.008) and female gender (P = 0.017), although positive proportions in TCs or ICs were not significantly related to lymph node metastasis. A multivariate analysis showed that high intensity of PD‐L1 expression in TCs was an independent risk factor for lymph node metastasis. Conclusions The results suggested that high intensity of PD‐L1 expression in TCs is associated with lymph node metastasis in cSCC.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between PD‐L1 expression and lymph node metastasis in cutaneous squamous cell carcinoma

Kamiya

Kato

Kamiya

et al. 2018

Asia-Pac J Clncl Oncology

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“…Unlike its oncogenic functions in melanoma, blockade of PD‐1 promoted tumour cell proliferation in nonsmall cell lung cancer . Studies on the expression of PD‐L1 in cutaneous squamous cell carcinoma (cSCC) have increased . Expression of PD‐1 has also been studied in cSCC …”

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confidence: 99%

Differential expression of programmed death‐1 according to the histological differentiation of cutaneous squamous cell carcinoma

Yang

Lee

et al. 2019

Br J Dermatol

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Association of Patient Risk Factors, Tumor Characteristics, and Treatment Modality With Poor Outcomes in Primary Cutaneous Squamous Cell Carcinoma

et al. 2023

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ImportancePrimary cutaneous squamous cell carcinoma is usually curable; however, a subset of patients develops poor outcomes, including local recurrence, nodal metastasis, distant metastasis, and disease-specific death.ObjectivesTo evaluate all evidence-based reports of patient risk factors and tumor characteristics associated with poor outcomes in primary cutaneous squamous cell carcinoma and to identify treatment modalities that minimize poor outcomes.Data SourcesPubMed, Embase, and SCOPUS databases were searched for studies of the topic in humans, published in the English language, from database inception through February 8, 2022.Study SelectionTwo authors independently screened the identified articles and included those that were original research with a sample size of 10 patients or more and that assessed risk factors and/or treatment modalities associated with poor outcomes among patients with primary cutaneous squamous cell carcinoma.Data Extraction and SynthesisData extraction was performed by a single author, per international guidelines. The search terms, study objectives, and protocol methods were defined before study initiation. A total of 310 studies were included for full-text assessment. Owing to heterogeneity of the included studies, a random-effects model was used. Data analyses were performed from May 25 to September 15, 2022.Main Outcomes and MeasuresFor studies of risk factors, risk ratios and incidence proportions; and for treatment studies, incidence proportions.ResultsIn all, 129 studies and a total of 137 449 patients with primary cutaneous squamous cell carcinoma and 126 553 tumors were included in the meta-analysis. Several patient risk factors and tumor characteristics were associated with local recurrence, nodal metastasis, distant metastasis, disease-specific death, and all-cause death were identified. Among all factors reported by more than 1 study, the highest risks for local recurrence and disease-specific death were associated with tumor invasion beyond subcutaneous fat (risk ratio, 9.1 [95% CI, 2.8-29.2] and 10.4 [95% CI, 3.0- 36.3], respectively), and the highest risk of any metastasis was associated with perineural invasion (risk ratio, 5.0; 95% CI, 2.3-11.1). Patients who received Mohs micrographic surgery had the lowest incidence of nearly all poor outcomes; however, in some results, the 95% CIs overlapped with those of other treatment modalities.Conclusions and RelevanceThis meta-analysis identified the prognostic value of several risk factors and the effectiveness of the available treatment modalities. These findings carry important implications for the prognostication, workup, treatment, and follow-up of patients with primary cutaneous squamous cell carcinoma.Trial RegistrationPROSPERO Identifier: CRD42022311250

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Tumor programmed cell death ligand 1 expression correlates with nodal metastasis in patients with cutaneous squamous cell carcinoma of the head and neck

Cited by 48 publications

References 32 publications

Association between PD‐L1 expression and lymph node metastasis in cutaneous squamous cell carcinoma

Association between PD‐L1 expression and lymph node metastasis in cutaneous squamous cell carcinoma

Differential expression of programmed death‐1 according to the histological differentiation of cutaneous squamous cell carcinoma

Association of Patient Risk Factors, Tumor Characteristics, and Treatment Modality With Poor Outcomes in Primary Cutaneous Squamous Cell Carcinoma

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